Regulation of Phosphoenolpyruvate Synthesis from Succinate in Guinea Pig Liver Mitochondria

Subcellular Distribution of Pyruvate Carboxylase and Phosphoenolpyruvate Carboxykinase in Dog Liver and Kidney

“…Therefore we must postulate another role for mitochondrial PEPck or show that the redox of the mitochondria is not as conventionally depicted; the latter possibility has been suggested (16). Earlier work from this laboratory (17) indicated that fatty acid oxidation as well as several other experimental conditions known to elevate the mitochondrial NADH/NAD+ ratio inhibited PEP synthesis is isolated intact guinea pig liver mitochondria which contain a large fraction of the total PEPck activity of guinea pig liver. Fatty acid oxidation has also been shown to inhibit gluconeogenesis in perfused liver (1 8, 19).…”