Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPα during axonal extension in hippocampal neurons

Cosker, Katharina E.; Shadan, Sadaf; Diepen, Michiel van; Morgan, Clive P.; Li, Michelle; Allen-Baume, Victoria; Hobbs, Carl; Doherty, Patrick; Cockcroft, Shamshad; Eickholt, Britta J.

doi:10.1242/jcs.019166

Cited by 49 publications

(47 citation statements)

References 40 publications

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“…Previous works have proved that BDNF facilitates axon elongation through BDNF/TrkB signaling (42,48,49). In this study, we found that BDNF had no effect on axonal elongation when LIMK1 was knocked down by siRNA, and BDNF stimulation further enhanced axonal growth in primary neurons transfected with wild-type LIMK1, suggesting that BDNF could induce axonal elongation in a manner dependent on LIMK1 activity.…”

Section: Discussionsupporting

confidence: 47%

LIM Kinase 1 (LIMK1) Interacts with Tropomyosin-related Kinase B (TrkB) and Mediates Brain-derived Neurotrophic Factor (BDNF)-induced Axonal Elongation

Dong

Cai

et al. 2012

Journal of Biological Chemistry

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Background: BDNF promotes axonal outgrowth, whereas the underlying molecular mechanism has remained unclear. Results: LIMK1 interacts with TrkB, and BDNF treatment could induce LIMK1 dimerization and transactivation, which facilitate axonal elongation. Conclusion: LIMK1-regulated actin dynamics is essential for BDNF-induced axonal elongation. Significance: These results revealed a novel mechanism for the BDNF-induced axonal elongation.

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Section: Discussionsupporting

confidence: 47%

LIM Kinase 1 (LIMK1) Interacts with Tropomyosin-related Kinase B (TrkB) and Mediates Brain-derived Neurotrophic Factor (BDNF)-induced Axonal Elongation

Dong

Cai

et al. 2012

Journal of Biological Chemistry

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“…Akt has also been implicated in synaptogenesis (Akama & McEwen, 2003) and synaptic transmission (Wang, et al, 2003). Others have found the pathway to be essential for elongation, guidance and branching of both axons and dendrites (Cosker, et al, 2008;Luikart, et al, 2008). These findings are consistent with the widespread distribution of Akt in the central nervous system.…”

Section: Cc2d1a and Akt Functionsupporting

confidence: 61%

The Freud-1/CC2D1A Family: Multifunctional Regulators Implicated in Mental Retardation

Millar¹,

Souslova²,

Albert³

2012

Latest Findings in Intellectual and Developmental Disabilities Research

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“…This may be a counterpart to the elaboration of multiple axons in the hippocampal paradigm outline above. Normally, GSK-3 inhibition and APC plus-end binging are localized to the axon growth cone downstream of PI3K signaling (Eickholt et al 2002;Zhou et al 2004;Cosker et al 2008). More general inhibition of GSK-3 may induce multiple foci along the axon capable of supporting efficient tubulin polymerization, thus resulting in branching.…”

Section: Gsk-3 and Axon Elongationmentioning

confidence: 99%

Initiating and Growing an Axon

Polleux¹,

Snider²

2010

Cold Spring Harbor Perspectives in Biology

163

127

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The ability of neurons to form a single axon and multiple dendrites underlies the directional flow of information transfer in the central nervous system. Dendrites and axons are molecularly and functionally distinct domains. Dendrites integrate synaptic inputs, triggering the generation of action potentials at the level of the soma. Action potentials then propagate along the axon, which makes presynaptic contacts onto target cells. This article reviews what is known about the cellular and molecular mechanisms underlying the ability of neurons to initiate and extend a single axon during development. Remarkably, neurons can polarize to form a single axon, multiple dendrites, and later establish functional synaptic contacts in reductionist in vitro conditions. This approach became, and remains, the dominant model to study axon initiation and growth and has yielded the identification of many molecules that regulate axon formation in vitro (Dotti et al. 1988). At present, only a few of the genes identified using in vitro approaches have been shown to be required for axon initiation and outgrowth in vivo. In vitro, axon initiation and elongation are largely intrinsic properties of neurons that are established in the absence of relevant extracellular cues. However, the importance of extracellular cues to axon initiation and outgrowth in vivo is emerging as a major theme in neural development (Barnes and Polleux 2009). In this article, we focus our attention on the extracellular cues and signaling pathways required in vivo for axon initiation and axon extension.

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Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPα during axonal extension in hippocampal neurons

Abstract: Supplementary material available online at

Cited by 49 publications

References 40 publications

LIM Kinase 1 (LIMK1) Interacts with Tropomyosin-related Kinase B (TrkB) and Mediates Brain-derived Neurotrophic Factor (BDNF)-induced Axonal Elongation

LIM Kinase 1 (LIMK1) Interacts with Tropomyosin-related Kinase B (TrkB) and Mediates Brain-derived Neurotrophic Factor (BDNF)-induced Axonal Elongation

The Freud-1/CC2D1A Family: Multifunctional Regulators Implicated in Mental Retardation

Initiating and Growing an Axon

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