Regulation of primordial follicle formation, dormancy, and activation in mice

Nagamatsu, Go

doi:10.1262/jrd.2021-040

Cited by 19 publications

(11 citation statements)

References 52 publications

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“…Therefore, its assessment is pivotal for monitoring women’s ovarian function during ovarian aging and reproductive treatment. Due to the small size and lack of hormone secretion of primordial follicles, a clinical tool to directly assess primordial follicles does not exist ( 23 ). Currently available assessment tools for ovarian reserve, i.e., serum follicle-stimulating hormone (FSH), serum anti-müllerian hormone (AMH), and antral follicle count (AFC), only assess a small fraction of all follicles.…”

Section: Clinical Relevance Of Oma and Ovarian Reservementioning

confidence: 99%

Impacts of endometrioma on ovarian aging from basic science to clinical management

Tan

Xue

et al. 2023

Front. Endocrinol.

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Endometriosis is a common reproductive disorder characterized by the presence of endometrial implants outside of the uterus. It affects ~1 in 10 women of reproductive age. Endometriosis in the ovary, also known as endometrioma (OMA), is the most frequent implantation site and the leading cause of reproductive failure in affected women. Ovarian aging is one of the characteristic features of OMA, however its underlying mechanism yet to be determined. Accumulated evidence has shown that pelvic and local microenvironments in women with OMA are manifested, causing detrimental effects on ovarian development and functions. Whilst clinical associations of OMA with poor ovarian reserve, premature ovarian insufficiency, and early menopause have been reported. Moreover, surgical ablation, fenestration, and cystectomy of OMA can further damage the normal ovarian reservoir, and trigger hyperactivation of primordial follicles, subsequently resulting in the undesired deterioration of ovarian functions. Nevertheless, there is no effective treatment to delay or restore ovarian aging. This review comprehensively summarised the pathogenesis and study hypothesis of ovarian aging caused by OMA in order to propose potential therapeutic targets and interventions for future studies.

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Section: Clinical Relevance Of Oma and Ovarian Reservementioning

confidence: 99%

Impacts of endometrioma on ovarian aging from basic science to clinical management

Tan

Xue

et al. 2023

Front. Endocrinol.

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“…In mammals, the number of oocytes is fixed after birth and they are stored as a quiescent state (the first stage of meiotic prophase) in primordial follicles. Following the normal onset of puberty, the regulation of the activation process of the primordial-to-primary follicle transition to support an ovulatory cycle is not fully understood [ 17 ]. Possible influences of HS on the regulatory mechanisms of maintaining the population of primordial follicles or their regulated activation are largely unknown.…”

Section: Follicular Development Under Conditions Of Heat Stressmentioning

confidence: 99%

Effects of Heat Stress on Follicular Physiology in Dairy Cows

Rensis

Saleri

García-Ispierto

et al. 2021

Animals

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Follicular organization starts during mid-to-late fetal life with the formation of primordial follicles. The bilateral interplay between the oocyte and adjoining somatic cells during follicular growth and ovulation may be sensitive to heat stress (HS). Mechanisms giving rise to pre-ovulatory temperature gradients across reproductive tissues are mostly regulated by the pre-ovulatory follicle, and because the cooling of the gonads and genital tract depends on a counter-current transfer system of heat, HS may be considered a major factor impairing ovulation, fertilization and early embryo development. There is evidence of a long-lasting influence of HS on oogenesis and final follicular maturation. Follicular stages that are susceptible to HS have not been precisely determined. Therefore, the aim of this review was to describe the influence of HS during the staged follicular development in dairy cattle, from the activation of primordial follicles to ovulation. Some clinical prospects are also considered.

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“…It is thus necessary to analyze whether the spatiotemporal expression patterns of FOXL2 and LGR5 are controlled in cultured ovaries, as well as in in vivo studies. Recently, the causes of skipping the primordial follicle state in vitro have been shown to be related to the oxygen concentration and tension generated by the extracellular matrix (Nagamatsu et al 2019;Shimamoto et al 2019;Nagamatsu 2021). Furthermore, theca cell layers are extremely thin in cultured ovaries, independent of ICI addition (Fig.…”

Section: Unresolved Problems Regarding In Vitro Follicle Formationmentioning

confidence: 99%

“…Recently, ovarian culture systems have been established to reproduce oocyte/follicle formation in vitro from mouse fetal ovaries containing PGCs, and from reconstituted ovaries with PGC-like and fetal ovarian somatic cell-like cells, both of which are differentiated from pluripotent stem cells (Hikabe et al 2016;Morohaku et al 2016b;Morohaku 2019;Yoshino et al 2021). Current in vitro systems do not fully reproduce in vivo oogenesis including folliculogenesis (Nagamatsu et al 2019;Shimamoto et al 2019;Nagamatsu 2021;Tanimoto et al 2021). Elucidating the causes of abnormal oogenesis in vitro will lead to a better understanding of the processes of normal oocyte and follicle formation in vivo and the renovation of in vitro systems.…”

Section: Introductionmentioning

confidence: 99%

Insights into in vivo follicle formation: a review of in vitro systems

Tanimoto

Yoshida

Ikeda

et al. 2021

Histochem Cell Biol

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In vitro systems capable of reconstituting the process of mouse oogenesis are now being established to help develop further understanding of the mechanisms underlying oocyte/follicle development and differentiation. These systems could also help increase the production of useful livestock or genetically modified animals, and aid in identifying the causes of infertility in humans. Recently, we revealed, using an in vitro system for recapitulating oogenesis, that the activation of the estrogen signaling pathway induces abnormal follicle formation, that blocking estrogen-induced expression of anti-Müllerian hormone is crucial for normal follicle formation, and that the production of α-fetoprotein in fetal liver tissue is involved in normal in vivo follicle formation. In mouse fetuses, follicle formation is not carried out by factors within the ovaries but is instead orchestrated by distal endocrine factors. This review outlines findings from genetics, endocrinology, and in vitro studies regarding the factors that can affect the formation of primordial follicles in mammals.

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Regulation of primordial follicle formation, dormancy, and activation in mice

Cited by 19 publications

References 52 publications

Impacts of endometrioma on ovarian aging from basic science to clinical management

Impacts of endometrioma on ovarian aging from basic science to clinical management

Effects of Heat Stress on Follicular Physiology in Dairy Cows

Insights into in vivo follicle formation: a review of in vitro systems

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