1999
DOI: 10.1016/s0303-7207(98)00251-2
|View full text |Cite
|
Sign up to set email alerts
|

Regulation of prolactin receptor glycosylation and its role in receptor location

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
9
0

Year Published

2000
2000
2019
2019

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 10 publications
(9 citation statements)
references
References 46 publications
0
9
0
Order By: Relevance
“…Previous data presented a differential role of the N-glycans for different cytokine receptor traffic, ligand binding, and function (Ding et al, 1995; Buteau et al, 1998; Bolander, 1999; Niu et al, 2000; Kamikubo et al, 2008; Waetzig et al, 2010). There are no available studies on the importance of the carbohydrate groups on the cell surface expression and function of human TpoR.…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…Previous data presented a differential role of the N-glycans for different cytokine receptor traffic, ligand binding, and function (Ding et al, 1995; Buteau et al, 1998; Bolander, 1999; Niu et al, 2000; Kamikubo et al, 2008; Waetzig et al, 2010). There are no available studies on the importance of the carbohydrate groups on the cell surface expression and function of human TpoR.…”
Section: Discussionmentioning
confidence: 96%
“…N-glycosylation is apparently not required for induction of gene transcription via PrlR and gp130, but is crucial for receptors’ stability and cell surface localization (Buteau et al, 1998; Bolander, 1999; Waetzig et al, 2010). On the other hand, in the case of leptin and GM-CSF receptors, N-glycans are important for ligand binding (Ding et al, 1995; Niu et al, 2000; Kamikubo et al, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, epithelial PRLR L levels increased while stromal PRLR L remained constant, indicating that most if not all the increase in PRLR expression seen in the mammary gland during pregnancy and lactation takes place in the epithelia. It should also be pointed out that the PRLR L was found to be present as three major isoforms, probably representing different levels of glycosylation of the receptor (Kelly & Rozakis-Adcock 1991, Bolander 1999). The significance of these different isoforms of the PRLR L is, at present, not understood.…”
Section: Discussionmentioning
confidence: 99%
“…Long form rat PRLR is detected as 82 kDa protein (Ali et al, 1991), which is close in size of truncated chPRLR possessing single extracellular domain. Furthermore prolactin receptor expressed in mammary epithelial cells as 78 and 70 kDa protein are reduced to a single 61 kDa molecules after N-glycanase F treatment (Bolander, 1999). Three putative N-linked glycosylation sites in mammalian PRLR are conserved in the ligand binding domains of chPRLR (Tanaka et al, 1992).…”
Section: Discussionmentioning
confidence: 99%