Regulation of Proliferation and Invasion in Endometriosis

Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches

“…The rarest areas of anatomical distribution have been reported on the hymen [ 41 ], the lung [ 42 ], nerves located in the pelvic compartments, as well as on surgical scars [ 43 ]. Based on the location of the endometrial implants, it is generally acknowledged that this disease can be divided into three categories such as peritoneal endometriosis, ovarian endometriosis, and deeply infiltrated endometriosis, each one this different pathogenesis presenting different invasive and proliferative mechanisms [ 44 ].…”

“…Physical examination, while executing the bimanual pelvic maneuver, points toward diagnosing endometriosis when several criteria are met such as palpable nodularity and abnormal pelvic anatomy, especially when located in the vagina and the rectovaginal space, the pouch of Douglas, the rectosigmoid, as well as the posterior wall of the urinary bladder [ 44 , 51 , 52 ]. Other signs such as tenderness, decreased mobility, and a retroverted uterus, evidenced while palpating, might also indicate signs of endometriosis [ 53 ].…”

“…Boergese et al and several other researchers published studies in regard to miRNA and its expression in the lesions of endometriosis, with the summarized results being shown in Table 1 . Even though the role of microRNAs has been intensely investigated, there is still inconsistent data regarding the regulation of processes involved in generating the endometriotic lesions, since the cells exhibit heterogeneous miRNA signatures with various properties [ 44 ].…”