Regulation of RASSF by non-coding RNAs in different cancers: RASSFs as masterminds of their own destiny as tumor suppressors and oncogenes

Farooqı, Ammad Ahmad; Kapanova, Gulnara; Kussainov, Abay Z.; Datkhayeva, Zaure; Raganina, Karlygash; Sadykov, Bolat

doi:10.1016/j.ncrna.2022.04.001

Cited by 3 publications

(1 citation statement)

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“…Linear pre-mRNAs generate circRNAs through back-splicing or skipping of exons. Importantly, circular form of circRNAs protected them from degradation by exonucleases and made them significantly stable (19)(20)(21)(22). Essentially, circR-NAs hold a great potential with reference to therapeutic applications for OSCC, either through inhibition or restoration of circRNAs that fine-tune cancer cells' regulatory networks (23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Regulatory role of circular RNAs in oral squamous cell carcinoma

Attar,

Noel,

Romero

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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OSCC is a genomically complicated disease and advancements in the modern era of molecular oncology have enabled researchers to portray near-to-complete resolution of signaling landscape. Over the last two decades, overwhelming proof-of-concept has established mechanistic regulatory role of non-coding RNAs in carcinogenesis, including OSCC. Circular RNAs demonstrate a burgeoning facet of oncology research and molecular biologists are only beginning to appreciate and recognize the significance of circRNAs in the pathogenesis of OSCC. Regulatory roles of non-coding RNAs in the re-shaping of signaling pathways offer plausible strategies for prevention/inhibition of OSCC. Circular RNAs have mechanistic roles in OSCC and "sponge effects" mediated by a wider variety of circRNAs need to be rationally targeted for effective cancer prevention. Phenomenal and cutting-edge research works in different types of animal models will further refine our knowledge for selection of most promising circRNAs as pharmacologically valuable targets.

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