Regulation of reactive oxygen species by phytochemicals for the management of cancer and diabetes

Lim, Heui Min; Park, See‐Hyoung

doi:10.1080/10408398.2022.2025574

Cited by 15 publications

(8 citation statements)

References 195 publications

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“…Ha et al proposed that HBx-triggered ROS reduces tumor suppressor phosphatase and tensin homologue (PTEN) by promoting PI3K-Akt signaling pathways that lead to chronic liver disease or carcinogenesis . Hepatic lipid accumulation influences many age-related diseases including fatty liver, liver cirrhosis, and metabolic syndrome. , Seo et al observed that the incorporation of ROS inducer, H 2 O 2 in HepG2 (a cancer cell line of the human liver) cells, and primary hepatocytes increased lipid accumulation to an extended rate compared to untreated HepG2 cells and primary hepatocytes in the rat model . The level of caveolin-1 and LDLR overexpression in H 2 O 2 -treated HepG2 cells and cholesterol uptake in primary hepatocytes was significantly higher, which indicates ROS plays a crucial role in metabolic liver disorder and age-associated problems (i.e., fatty liver) .…”

Section: Effect Of Ros On Aging and Age-associated Diseasementioning

confidence: 99%

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Anik

Mahmud²,

Masud

et al. 2022

ACS Appl. Bio Mater.

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Research on the role of reactive oxygen species (ROS) in the aging process has advanced significantly over the last two decades. In light of recent findings, ROS takes part in the aging process of cells along with contributing to various physiological signaling pathways. Antioxidants being cells' natural defense mechanism against ROS-mediated alteration, play an imperative role to maintain intracellular ROS homeostasis. Although the complete understanding of the ROS regulated aging process is yet to be fully comprehended, current insights into various sources of cellular ROS and their correlation with the aging process and age-related diseases are portrayed in this review. In addition, results on the effect of antioxidants on ROS homeostasis and the aging process as well as their advances in clinical trials are also discussed in detail. The future perspective in ROS-antioxidant dynamics on antiaging research is also marshaled to provide future directions for ROS-mediated antiaging research fields.

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Section: Effect Of Ros On Aging and Age-associated Diseasementioning

confidence: 99%

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Anik

Mahmud²,

Masud

et al. 2022

ACS Appl. Bio Mater.

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“…There are specific biomarkers overexpressed in diabetic patients, e.g. , glycated haemoglobin, 105 glycated albumin, 106 reactive oxygen species, 107–109 high viscosity, 110,111 and volatile organic compounds like acetone, aldehyde, etc. These biomarkers have been proved to be of great benefit for the early diagnosis of diabetes.…”

Section: Applications Of Viscosity Probes In Diabetes Treatmentmentioning

confidence: 99%

Mechanistic analysis of viscosity-sensitive fluorescent probes for applications in diabetes detection

Sreejaya,

M Pillai,

et al. 2024

J. Mater. Chem. B

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“…New cancer survival and mortality control techniques are needed ( Da Silva et al, 2016 ; Dai et al, 2017 ; Pucci et al, 2019 ; Mahdinloo et al, 2020 ; Bagherifar et al, 2021 ). As an alternative or complementary to traditional chemo or radiotherapy, naturally occurring phytochemicals (such as flavonoids, isoflavones, and lignans) with antioxidant or hormone-like actions are being explored for cancer ( Ghosh et al, 2021a ; Ahmad et al, 2021 ; Aboushanab et al, 2022 ; Lim & Park, 2022 ). These cancer-suppressing phytochemicals act mainly by affecting the signaling molecules that have either been abnormally activated or silenced.…”

Section: Introductionmentioning

confidence: 99%

Use of gold nanoparticle-silibinin conjugates: A novel approach against lung cancer cells

Ravi

Zeyaullah²,

Ghosh³

et al. 2022

Front. Chem.

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Lung cancer presents one of the most challenging carcinomas with meager 5-year survival rates (less than 20%), high metastasis and high recurrence due to chemo- and radio- resistance. An alternative or complementation to existing prognosis modalities is the use of phytochemicals such as silibinin, which targets essential cytokines, angiogenic factors and transcription factors for a profound anti-tumor effect. However, the problems of low solubility in an aqueous physiological environment, poor penetration, high metabolism and rapid systemic clearance limit the therapeutic use of silibinin. Conjugation of gold nanoparticles (GNPs) with silibinin may overcome the above challenges along with distinct advantages of biocompatibility, optical properties for monitoring and causation of cytotoxicity in cancer cells. The current study thus aims to develop silibinin conjugated gold nanoparticles (Sb-GNPs) with pH responsive release in the cancer microenvironment, optimizing several parameters for its higher activity and further evaluate the nanoplatform for their efficacy in inducing cell death in vitro against A549 lung cancer cells. GNPs was synthesized using trisodium citrate dihydrate as the reducing agent and further used for the conjugation of silibinin. The synthesized GNPs were found to be monodispersed and spherical in shape. The silibinin was successfully conjugated with gold nanoparticles and long-term stability of GNPs and Sb-GNPs nanoconjugates in suspension phase was confirmed by FTIR and DLS. Anticancer properties of Sb-GNPs were confirmed by different assay using MTT, Trypan blue dye exclusion assay and cell cycle analysis assay. After conjugation of silibinin with GNPs, the efficacy of silibinin increased 4–5 times in killing the cancer cells. This is the first report on using silibinin gold nanoconjugate system for lung cancer therapy with promising future applications.

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Regulation of reactive oxygen species by phytochemicals for the management of cancer and diabetes

Cited by 15 publications

References 195 publications

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

Mechanistic analysis of viscosity-sensitive fluorescent probes for applications in diabetes detection

Use of gold nanoparticle-silibinin conjugates: A novel approach against lung cancer cells

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