Regulation of regulated cell death by extracellular vesicles in acute kidney injury and chronic kidney disease

Zhou, Zixuan; Shi, Linru; Chen, Binghai; Qian, Hui

doi:10.1016/j.cytogfr.2023.12.006

Cytokine & Growth Factor Reviews

2024

DOI: 10.1016/j.cytogfr.2023.12.006

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Regulation of regulated cell death by extracellular vesicles in acute kidney injury and chronic kidney disease

Zixuan Zhou,

Linru Shi,

Binghai Chen

et al.

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2024

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Cited by 3 publications

References 171 publications

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Extracellular vesicles: Illuminating renal pathophysiology and therapeutic frontiers

Shi,

Zeng,

et al. 2024

European Journal of Pharmacology

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Extracellular vesicles: Illuminating renal pathophysiology and therapeutic frontiers

Shi,

Zeng,

et al. 2024

European Journal of Pharmacology

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Mesenchymal stem cell-derived extracellular vesicles ameliorate renal interstitial fibrosis via the miR-13474/ADAM17 axis

Shi,

Hu,

Zeng

et al. 2024

Sci Rep

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Renal interstitial fibrosis (RIF) is a prevalent consequence of chronic renal diseases, characterized by excessive extracellular matrix (ECM) deposition. A Disintegrin and Metalloprotease 17 (ADAM17), a transmembrane metalloproteinase, plays a central role in driving renal fibrosis progression by activating Notch 1 protein and the downstream TGF-β signaling pathway. Our study investigated potential therapeutic interventions for renal fibrosis, focusing on human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hucMSC-EVs). We found that hucMSC-EVs inhibit ADAM17, thereby impeding renal fibrosis progression. Analysis of hucMSC-EVs miRNA profiles revealed significant enrichment of miR-13474, which effectively targeted and inhibited ADAM17 mRNA expression, subsequently suppressing Notch1 activation, TGF-β signaling, and collagen deposition. Overexpression of miR-13474 enhanced hucMSC-EVs' inhibitory effect on renal fibrosis, while its downregulation abolished this protective effect. Our findings highlight the efficacy of hucMSC-EVs overexpressing miR-13474 in mitigating renal fibrosis via ADAM17 targeting. These insights offer potential therapeutic strategies for managing renal fibrosis.

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Frontier role of extracellular vesicles in kidney disease

Li,

Qi,

Zhang

et al. 2024

J Nanobiotechnol

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Regulation of regulated cell death by extracellular vesicles in acute kidney injury and chronic kidney disease

Cited by 3 publications

References 171 publications

Extracellular vesicles: Illuminating renal pathophysiology and therapeutic frontiers

Extracellular vesicles: Illuminating renal pathophysiology and therapeutic frontiers

Mesenchymal stem cell-derived extracellular vesicles ameliorate renal interstitial fibrosis via the miR-13474/ADAM17 axis

Frontier role of extracellular vesicles in kidney disease

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