Regulation of SARS-CoV-2 infection by diet-modulated gut microbiota

Tieu, Vanessa; Tibi, Sedra; Liu, Jun

doi:10.3389/fcimb.2023.1167827

Cited by 6 publications

(5 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, microbiota might influence the disease severity of COVID-19 in the setting of T2DM through the production of important metabolites, such as SCFAs and TMAO [ 350 ]. As mentioned above, butyrate and other SCFA-producing bacterial spp.…”

Section: Effects Of Nutrition On Gut Microbiota In Individuals With C...mentioning

confidence: 99%

“…These beneficial changes occurred through the inactivation of the NF-Kβ signaling pathway as well as a decreasing expression of ACE2, an important regulator in COVID-19 disease severity [ 361 ]. Taken together, these findings suggest that nutrition may serve an important role in regulating pathophysiologic changes in COVID-19 outcome through the optimization of microbiota-related metabolites [ 350 ]. Therefore, improving dietary intake in individuals with chronic inflammatory diseases such as those with T2DM may improve outcomes when affected by COVID-19.…”

Section: Effects Of Nutrition On Gut Microbiota In Individuals With C...mentioning

confidence: 99%

See 1 more Smart Citation

Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

Hamamah,

Iatcu,

Covasa

2024

Nutrients

View full text Add to dashboard Cite

Nutrition is one of the most influential environmental factors in both taxonomical shifts in gut microbiota as well as in the development of type 2 diabetes mellitus (T2DM). Emerging evidence has shown that the effects of nutrition on both these parameters is not mutually exclusive and that changes in gut microbiota and related metabolites such as short-chain fatty acids (SCFAs) and branched-chain amino acids (BCAAs) may influence systemic inflammation and signaling pathways that contribute to pathophysiological processes associated with T2DM. With this background, our review highlights the effects of macronutrients, carbohydrates, proteins, and lipids, as well as micronutrients, vitamins, and minerals, on T2DM, specifically through their alterations in gut microbiota and the metabolites they produce. Additionally, we describe the influences of common food groups, which incorporate varying combinations of these macronutrients and micronutrients, on both microbiota and metabolic parameters in the context of diabetes mellitus. Overall, nutrition is one of the first line modifiable therapies in the management of T2DM and a better understanding of the mechanisms by which gut microbiota influence its pathophysiology provides opportunities for optimizing dietary interventions.

show abstract

Section: Effects Of Nutrition On Gut Microbiota In Individuals With C...mentioning

confidence: 99%

Section: Effects Of Nutrition On Gut Microbiota In Individuals With C...mentioning

confidence: 99%

Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

Hamamah,

Iatcu,

Covasa

2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…However, the precise mechanisms of chemical and molecular crosstalk are poorly understood [ 79 ]. For example, it has been shown that elevated levels of trimethylamine N-oxide (TMAO) are associated with the pathogenesis of Alzheimer’s disease and are known to result in increased formation of reactive oxygen species and pro-inflammatoy cytokines [ 80 , 81 ]. Production of TMAO is known to be associated with the increased population of Ruminococcus bacteria in Alzheimer’s patients and also been found to be elevated in the gut flora of COVID-19 patients [ 82 , 83 ] providing a potential common link between the two conditions.…”

Section: Perspectivesmentioning

confidence: 99%

COVID-19 and Alzheimer’s disease: Impact of lockdown and other restrictive measures during the COVID-19 pandemic

Nawaz,

Haider,

Akhtar

2024

Biomol Biomed

View full text Add to dashboard Cite

SARS-CoV-2 infection initially results in respiratory distress symptoms but can also lead to CNS and neurological manifestations, significantly impacting COVID-19 patients with neurodegenerative diseases. Additionally, strict lockdown measures introduced to curtail the spread of COVID-19 have raised concerns over the wellbeing of patients with dementia and/or Alzheimer’s disease. The aim of this review is to discuss the overlapping molecular pathologies and the potential bi-directional relationship between COVID-19 and Alzheimer’s dementia, as well as the impact of lockdown/restriction measures on the neuropsychiatric symptoms of Alzheimer's dementia patients. Furthermore, we aim to assess the impact of lockdown measures on the neuropsychiatric symptoms of caregivers and how this might influence the degree and quality of care provided to dementia patients. We utilized the PubMed and Google Scholar databases to search for articles on COVID-19, dementia, Alzheimer’s disease, lockdown, and caregivers. Our review highlights that patients with Alzheimer’s disease are at an increased risk of COVID-19 infection and complications, such as greater cognitive decline, which likely arise as a result of the SARS-CoV-2 infection and appear to be further exacerbated by restrictive/lockdown measures. Moreover, lockdown measures introduced during the pandemic have negatively impacted both the neuropsychiatric symptoms of caregivers and their perception of the wellbeing of their Alzheimer’s patients. Thus, additional safeguard measures, along with pharmacological and non-pharmacological approaches, are needed to protect the wellbeing of dementia patients and their caregivers in light of this and possible future pandemics.

show abstract

“…Metabolites secreted by microbes such as short chain fatty acids (SCFAs) and certain indole derivatives are linked to immune regulation and anti-inflammatory properties. An uncontrolled and dysregulate immune response adds severity to COVID-19 and these metabolites may participate in the modulation of immunological response, reducing excessive inflammation and tissue damage ( Tieu et al., 2023 ; Wang M. et al., 2023 ). Some alpha bacterial strains such as Catenibacterium, Ruminococcus, and Eubacterium produce abundant SCFAs, compared with other delta strains.…”

Section: Microbial Metabolites In Immunological Modulationmentioning

confidence: 99%

“…SCFAs), contributing to the maintenance of balanced gut microbial populations and gut integrity. Similarly, the oral intake of beneficial microbes as supplements (probiotics) facilitates healthy microbial gut counts ( Tieu et al., 2023 ). Several clinical studies have shown the positive impact of adding healthy microorganisms to the gut and their effectiveness can also be reflected in the lung cells, via the described bidirectional pathway ( Table 5 ).…”

Section: Therapeutic Approaches and Future Directionsmentioning

confidence: 99%

COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens

Raj,

Bruce,

Anbalagan

et al. 2024

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The novel coronavirus disease 2019 (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has garnered unprecedented global attention. It caused over 2.47 million deaths through various syndromes such as acute respiratory distress, hypercoagulability, and multiple organ failure. The viral invasion proceeds through the ACE2 receptor, expressed in multiple cell types, and in some patients caused serious damage to tissues, organs, immune cells, and the microbes that colonize the gastrointestinal tract (GIT). Some patients who survived the SARS-CoV-2 infection have developed months of persistent long-COVID-19 symptoms or post-acute sequelae of COVID-19 (PASC). Diagnosis of these patients has revealed multiple biological effects, none of which are mutually exclusive. However, the severity of COVID-19 also depends on numerous comorbidities such as obesity, age, diabetes, and hypertension and care must be taken with respect to other multiple morbidities, such as host immunity. Gut microbiota in relation to SARS-CoV-2 immunopathology is considered to evolve COVID-19 progression via mechanisms of biochemical metabolism, exacerbation of inflammation, intestinal mucosal secretion, cytokine storm, and immunity regulation. Therefore, modulation of gut microbiome equilibrium through food supplements and probiotics remains a hot topic of current research and debate. In this review, we discuss the biological complications of the physio-pathological effects of COVID-19 infection, GIT immune response, and therapeutic pharmacological strategies. We also summarize the therapeutic targets of probiotics, their limitations, and the efficacy of preclinical and clinical drugs to effectively inhibit the spread of SARS-CoV-2.

show abstract

Regulation of SARS-CoV-2 infection by diet-modulated gut microbiota

Cited by 6 publications

References 103 publications

Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

Nutrition at the Intersection between Gut Microbiota Eubiosis and Effective Management of Type 2 Diabetes

COVID-19 and Alzheimer’s disease: Impact of lockdown and other restrictive measures during the COVID-19 pandemic

COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens

Contact Info

Product

Resources

About