Regulation of Skeletal Muscle by microRNAs

Diniz, Gabriela Placoná; Wang, Dazhi

doi:10.1002/cphy.c150041

Cited by 63 publications

(58 citation statements)

References 112 publications

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“…A study on translational repression without RNA destabilization has also been reported (38). In muscle atrophy, the expression levels of miR-30 family were reduced (39), which is consistent with our present study.…”

Section: Discussionsupporting

confidence: 92%

IncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR‐30c

et al. 2017

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Long noncoding RNAs (lncRNAs) have been reported to play diverse roles in biologic and pathologic processes, including myogenesis. We found that lncRNA is highly expressed in skeletal muscle cells. Functional analyses showed that overexpression of promoted proliferation and restrained differentiation of myoblasts; whereas inhibition of had completely opposite effects In mice, knockdown of promoted muscle hypertrophy RNA molecules of acted mechanistically as competing endogenous RNAs to target micro-RNA (miR)-30c, which was supported by the results of bioinformatics analyses and dual-luciferase reporter assays. It has been shown that lncRNA competes with trinucleotide repeat containing-6A () for miR-30c. was previously reported to promote proliferation and inhibit differentiation of myoblast cells, whereas miR-30c targets the 3'-UTR of mRNA to weaken its function. Taken together, lncRNA promotes proliferation and inhibits differentiation of myoblast cells by attenuating function of miR-30c.-Liang, T., Zhou, B., Shi, L., Wang, H., Chu, Q., Xu, F., Li, Y., Chen, R., Shen, C., Schinckel, A. P. lncRNA promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR-30c.

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Section: Discussionsupporting

confidence: 92%

IncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR‐30c

et al. 2017

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“…Subsets of miRNAs can be described as striated muscle‐specific (miR‐1, miR‐133a, miR‐133b, miR‐206, miR‐208a, miR‐208b, and miR‐499) or muscle‐enriched (miR‐486). They are involved in myoblast proliferation/differentiation, muscle regeneration, or fibre‐type specification (for review, refer to Diniz and Wang). The tissue specificity of myomiRs is due either to the genomic location of their coding DNA within introns of myosin heavy chain genes or to transcriptional control by muscle‐specific transcription factors such as MyoD, Mef2, or Srf .…”

Section: Microrna Biogenesis and Myomirsmentioning

confidence: 99%

Circulating myomiRs: a new class of biomarkers to monitor skeletal muscle in physiology and medicine

Siracusa¹,

Koulmann

Banzet

2017

J cachexia sarcopenia muscle

106

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MicroRNAs (miRNA) are small non‐coding RNAs that target mRNAs and are consequently involved in the post‐transcriptional regulation of gene expression. Some miRNAs are ubiquitously expressed in tissue, while others are tissue‐specific or tissue‐enriched. miRNAs can be released by cells and are found in various biofluids, including serum and plasma. Thus, measuring miRNAs in the circulation may provide information on the originating tissue or cells. MyomiRs are described as striated muscle‐specific or muscle‐enriched miRNAs. Their circulating levels can be measured and have been proposed to be new biomarkers of physiological and pathological muscle processes. The aims of this review are to summarize the current knowledge of circulating myomiRs, to identify the types of information they can provide about skeletal muscle, and to determine how to apply that information in the fields of research and medicine.

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“…MiRNAs are non-coding RNAs, 19-22 nucleotides long, which act as post-transcriptional regulators of gene expression. The role of miRNAs in the regulation of key biological processes in skeletal muscle is well-established (9) and they serve as diagnostic, prognostic biomarkers, and as molecular outcome measures in various biomedical fields (10,11). Previously, our group used gene network analysis to identify two miRNAs, miR-30c, and miR-181a and validated them as reliable serum diagnostic biomarkers for DMD (12).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Study of Three microRNAs in Duchenne Muscular Dystrophy and Becker Muscular Dystrophy

et al. 2020

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Our objective was to investigate the potential of three microRNAs, miR-181a-5p, miR-30c-5p, and miR-206 as prognostic biomarkers for long-term follow up of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) patients. We analyzed the expression of three microRNAs in serum of 18 patients (DMD 13, BMD 5) and 13 controls using droplet digital PCR. Over 4 years a minimum of two and a maximum of three measurements were performed at different time points in the same patient. Correlations between microRNA serum levels, age, and functional outcome measures were analyzed. We show the individual evolution of the levels of the three microRNAs in 12 patients and also the effect of corticosteroid treatment on microRNAs expression. We measure the expression of three microRNAs in the muscle of six DMD patients and also the expression of target genes for miR-30c. We found that levels of miR-30c and miR-206 remained significantly elevated in DMD patients relative to controls over the entire study length. The introduction of the corticosteroid treatment did not significantly influence the levels of these microRNAs. We report a trend for microRNA levels to decrease with age. Moreover, miR-206 expression levels are capable to distinguish DMD from BMD patients according to ROC analysis. We found miR-30c expression decreased in the muscle of DMD patients and marked upregulation of the target genes for this microRNA. MiR-30c and miR-206 represent sensitive biomarkers for DMD, while miR-206 may have an additional value to distinguish the DMD and BMD phenotype. This may be particularly relevant to assess the effectiveness of treatments aimed at converting the DMD to the less-severe BMD like phenotype.

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Regulation of Skeletal Muscle by microRNAs

Cited by 63 publications

References 112 publications

IncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR‐30c

IncRNA AK017368 promotes proliferation and suppresses differentiation of myoblasts in skeletal muscle development by attenuating the function of miR‐30c

Circulating myomiRs: a new class of biomarkers to monitor skeletal muscle in physiology and medicine

Longitudinal Study of Three microRNAs in Duchenne Muscular Dystrophy and Becker Muscular Dystrophy

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