Regulation of sodium and calcium in <i>Daphnia magna</i> exposed to silver nanoparticles

Zhao, Cheng; Wang, Wen‐Xiong

doi:10.1002/etc.2133

Cited by 9 publications

(3 citation statements)

References 37 publications

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“…Their data also indicated that the release of Ag + from AgNPs played a role in the observed toxicity. Zhao and Wang showed that soluble Ag released from AgNPs was toxic to D. magna by inhibiting sodium uptake. Jo et al suggested that the acute toxicity of AgNPs was mainly associated with dissolved concentrations of Ag.…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticle toxicity to Daphnia magna is a function of dissolved silver concentration

Newton

Puppala

Kitchens

et al. 2013

Environmental Toxicology and Chemistry

104

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The most persistent question regarding the toxicity of silver nanoparticles (AgNPs) is whether this toxicity is due to the nanoparticles themselves or the silver ions (Ag(+)) they release. The present study investigates the role of surface coating and the presence of dissolved organic carbon on the toxicity of AgNPs to Daphnia magna and tests the hypothesis that the acute toxicity of AgNPs is a function of dissolved Ag produced by nanoparticle dissolution. Toxicity of silver nitrate (AgNO3) and AgNPs with surface coatings-gum arabic (AgGA), polyethylene glycol (AgPEG), and polyvinylpyrrolidone (AgPVP)-at 48 h was assessed in US Environmental Protection Agency moderately hard reconstituted water alone and augmented with Suwannee River dissolved organic carbon (DOC). As expected, AgNO3 was the most toxic to D. magna and AgPVPs were the least toxic. In general, Suwannee River DOC presence reduced the toxicity of AgNO3, AgGAs, and AgPEG, while the toxicity of AgPVPs was unaffected. The measured dissolved Ag concentrations for all AgNPs and AgNO3 at the 48-h median lethal concentration in moderately hard reconstituted water were similar. The presence of Suwannee River DOC decreased the ratio of measured dissolved Ag to measured total Ag concentration. These results support the hypothesis that toxicity of AgNPs to D. magna is a function of dissolved Ag concentration from these particles.

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Section: Introductionmentioning

confidence: 99%

Silver nanoparticle toxicity to Daphnia magna is a function of dissolved silver concentration

Newton

Puppala

Kitchens

et al. 2013

Environmental Toxicology and Chemistry

104

View full text Add to dashboard Cite

show abstract

“…In addition, many studies have attempted to differentiate the mechanisms of toxicity between AgNPs and AgNO 3 to determine whether toxicity is solely related to Ag + released from the nanoparticles or whether there is a nanoparticle‐specific effect. Although dissolved silver clearly plays a major role in toxicity , there is some evidence of nanoparticle‐specific toxicity, particularly related to oxidative stress .…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticle toxicity to Atlantic killifish (Fundulus heteroclitus) and Caenorhabditis elegans: A comparison of mesocosm, microcosm, and conventional laboratory studies

Bone

Matson

Colman

et al. 2014

Environmental Toxicology and Chemistry

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The use of silver nanoparticles (AgNPs) in consumer products and industrial applications, as well as their recent detection in waste streams, has created concern about potential impacts on aquatic ecosystems. The effect of complex environmental media on AgNP toxicity was investigated using wetland mesocosms and smaller scale microcosms. Mesocosms were dosed with 2.5 mg Ag/L as gum arabic (GA)-coated AgNPs, polyvinylpyrrolidone (PVP)-coated AgNPs, or AgNO3. Water samples were taken from mesocosms 24 h after dosing for acute toxicity tests with embryos and larvae of Atlantic killifish (Fundulus heteroclitus) and the nematode Caenorhabditis elegans. Acute toxicity tests were also performed on Atlantic killifish with AgNO3, GA AgNPs, and PVP AgNPs prepared in the laboratory with similar water. For killifish embryos, mesocosm samples were much less toxic than laboratory samples for all types of silver. For larvae, in contrast, all 3 silver mesocosm treatments exhibited toxicity. Interestingly, mesocosm samples of AgNO3 were less toxic than laboratory samples; samples containing GA AgNPs were similar in toxicity, and samples containing PVP AgNPs were more toxic. For C. elegans, results were similar to killifish larvae. Results obtained from the mesocosms were not replicated on the smaller scale of the microcosms. These results indicate that environmental factors unique to the mesocosms acted differentially on AgNO3 to reduce its toxicity in a manner that does not translate to AgNPs for larval fish.

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“…Nonetheless, dissolved Ag concentrations in solution (as determined by ultrafiltration) explained toxicity and thus they concluded that particle dissolution was responsible for the observed effects. Studies with Daphnia magna exposed to Ag NMs coated with polyvinylpyrrolidone (PVP) noted reduced Na þ influx and disruption of Na þ regulation at 500 mg Ag L À1 , however this effect was also attributed to dissolution of Ag þ given that is was not seen when cysteine was added to the medium (cysteine-Ag þ complexes are not bioavailable [197] ). In some of these studies, there is an indication that both NMs and Ag þ induce toxicity, and it is generally not possible to distinguish one potential cause from another.…”

Section: Silver Nmsmentioning

confidence: 99%

Aquatic toxicity of manufactured nanomaterials: challenges and recommendations for future toxicity testing

et al. 2014

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Environmental context. The increased use of nanomaterials in industrial and consumer products requires robust strategies to identify risks when they are released into the environment. Aquatic toxicologists are beginning to possess a clearer understanding of the chemical and physical properties of nanomaterials in solution, and which of the properties potentially affect the health of aquatic organisms. This review highlights the main challenges encountered in aquatic nanotoxicity testing, provides recommendations for overcoming these challenges, and discusses recent studies that have advanced our understanding of the toxicity of three important OECD nanomaterials, titanium dioxide, zinc oxide and silver nanomaterials.Abstract. Aquatic nanotoxicologists and ecotoxicologists have begun to identify the unique properties of the nanomaterials (NMs) that potentially affect the health of wildlife. In this review the scientific aims are to discuss the main challenges nanotoxicologists currently face in aquatic toxicity testing, including the transformations of NMs in aquatic test media (dissolution, aggregation and small molecule interactions), and modes of NM interference (optical interference, adsorption to assay components and generation of reactive oxygen species) on common toxicity assays. Three of the major OECD (Organisation for Economic Co-operation and Development) priority materials, titanium dioxide (TiO 2 ), zinc oxide (ZnO) and silver (Ag) NMs, studied recently by the Natural Sciences and Engineering Research Council of Canada (NSERC), National Research Council of Canada (NRC) and the Business Development Bank of Canada (BDC) Nanotechnology Initiative (NNBNI), a Canadian consortium, have been identified to cause both bulk effect, dissolution-based (i.e. free metal), or NM-specific toxicity in aquatic organisms. TiO 2 NMs are most toxic to algae, with toxicity being NM size-dependent and principally associated with binding of the materials to the organism. Conversely, dissolution of Zn and Ag NMs and the subsequent release of their ionic metal counterparts appear to represent the primary mode of toxicity to aquatic organisms for these NMs. In recent years, our understanding of the toxicological properties of these specific OECD relevant materials has increased significantly. Specifically, researchers have begun to alter their experimental design to identify the different behaviour of these materials as colloids and, by introducing appropriate controls and NM characterisation, aquatic nanotoxicologists are now beginning to possess a clearer understanding of the chemical and physical properties of these materials in solution, and how these materials may interact with organisms. Arming nanotoxicologists with this understanding, combined with knowledge of the physics, chemistry and biology of these materials is essential for maintaining the accuracy of all future toxicological assessments.

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Regulation of sodium and calcium in Daphnia magna exposed to silver nanoparticles

Cited by 9 publications

References 37 publications

Silver nanoparticle toxicity to Daphnia magna is a function of dissolved silver concentration

Silver nanoparticle toxicity to Daphnia magna is a function of dissolved silver concentration

Silver nanoparticle toxicity to Atlantic killifish (Fundulus heteroclitus) and Caenorhabditis elegans: A comparison of mesocosm, microcosm, and conventional laboratory studies

Aquatic toxicity of manufactured nanomaterials: challenges and recommendations for future toxicity testing

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