Regulation of Somatomedin-C/Insulin-Like Growth Factor I by Nutrients

Le, Underwood; Dr, Clemmons; Maes, Marc; Aj, D'Ercole; Ketelslegers, J. M.

doi:10.1159/000180556

Cited by 127 publications

(45 citation statements)

References 15 publications

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“…This finding confirms that of several other groups in both animals and man (Underwood et al 1986, Vance et al 1992, Thissen et al 1994, Ohashi et al 1995. Not only is secretion of IGF-I reduced with fasting, but also synthesis is reduced as evidenced by falls in IGF-I mRNA (Zhang et al 1994, Kobayashi et al 1995.…”

Section: Discussionsupporting

confidence: 91%

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Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting

LaPaglia

Steiner²,

Kirsteins³

et al. 1998

Journal of Endocrinology

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Proper nutritional status is critical for maintaining growth and metabolic function, playing an intimate role in neuroendocrine regulation. Leptin, the recently identified product of the obese gene, may very well be an integral signal which regulates neuroendocrine responses in times of food deprivation. The present study examines leptin's ability to regulate hormonal synthesis and secretion within the GRF-GH-IGF axis in the adult male rat during almost 3 days of fasting. Serum levels of GH and IGF-I were drastically suppressed by fasting. Daily leptin administration was able to fully prevent the fasting-induced fall in serum GH. Leptin failed to restore IGF-I to control levels, however, suggesting possible GH resistance. Fasting caused an insignificant increase in GH mRNA, while leptin injections significantly increased steady-state levels of this message. The GRF receptor (GRFr) message was not altered with fasting or leptin treatment. Leptin also exhibited effects at the hypothalamic level. Fasting induced a sharp fall in GRF mRNA expression and leptin injections partially prevented this fall. However, there were no observed changes in the hypothalamic GRF content. These results provide evidence that leptin may function as a neuromodulator of the GRF-GH-IGF axis communicating to this hormonal system the nutritional status of the animal.

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Section: Discussionsupporting

confidence: 91%

“…IGF-I is also depressed (Underwood et al 1986, Vance et al 1992, Ohashi et al 1995 during fasting. It has been recently reported that impaired somatostatin distribution and release may also contribute to changes seen in the GH axis in nutritionally deprived animals (Aguila & McCann 1987, Sonntag et al 1995.…”

Section: Introductionmentioning

confidence: 94%

Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting

LaPaglia

Steiner²,

Kirsteins³

et al. 1998

Journal of Endocrinology

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“…It is well established that increased total energy intake results in higher levels of IGF-I [29]. The lower IGFBP-1 in Sandwell Gujaratis is in keeping with lower insulin sensitivity (HOMA-S; Table 2), as we have described previously in other ethnic groups [15].…”

Section: Discussionsupporting

confidence: 77%

Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India

et al. 2005

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Aims/hypotheses: We previously reported independent links between the IGF system and the development of impaired glucose tolerance and cardiovascular risk. This study tests the hypothesis that the lifestyle change which accompanies population migration, with attendant increases in cardiovascular risk, is reflected by changes in the IGF system. Materials and methods: We compared a specific Gujarati community in Sandwell, UK (n=205), with people still resident in the same villages of origin near Navsari, India (n=246). We performed anthropometry and measured fasting plasma insulin, IGF-I, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3. Results: Daily calorie intake, BMI and WHR were significantly higher in UK Gujaratis than in Indian Gujaratis. IGFBP-1 was significantly lower in UK migrants (mean 29.5 [95% CI 25.9-33.0] vs 56.5 [50.6-62.5]μg/l; F=48.4, p<0.001). Conversely, fasting insulin, IGFBP-3 and IGF-I were all higher in UK Gujaratis (mean IGF-I 145.9 [138.1-153.6]ng/ml in UK Gujaratis and 100.9 [94.6-107.3] ng/ml in Navsari Gujaratis; F=76.6, p<0.001). These differences were still apparent when adjustment was made for BMI by location for IGF-I (F=57.4, p<0.001) and IGFBP-3 (F=5.7, p=0.02), but were no longer apparent for IGFBP-1 and insulin. At the population level, the decrease in IGFBP-1 for a given increase in insulin was significantly smaller in UK Gujaratis, suggesting greater hepatic insulin resistance in this group. Conclusions/interpretation: Environmental factors have profound effects on circulating IGF system components and on the relationship between IGFBP-1, IGF-I and related metabolic variables. This may have long-term implications for the development of worsening glucose tolerance and cardiovascular disease.

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“…A Consensus Development Conference on Treatment of Destructive Behaviors in Persons with Developmental Disabilities will be held in Masur Auditorium in the Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, September 1 [1][2][3][4][5][6][7][8][9][10][11][12][13]1989. This open forum will focus on the various treatments and approaches used to modify or eliminate destructive behaviors in persons with developmental disabilities.…”

Section: Announcementmentioning

confidence: 99%

The Effects of Altered Nutritional Status upon Insulin-Like Growth Factors and their Binding Proteins in Neonatal Rats

et al. 1989

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ABSTRACT. To investigate the role of nutrition in the regulation of IGFs during the perinatal period, 10-d-old rats were infused intravenously with various concentrations of nutrients for 24 h. Breast-fed litter mates served as controls. The effect of caloric intake on concentrations of IGF-I and IGF-I1 as well as IGF-binding proteins in serum, liver, and brain of neonatal rats was studied. A total of 45 rats from 10 litters was infused with solutions ranging from a caloric intake of 0 (saline) to 75% (glucose, amino acids, and lipids) of the estimated intake of control rats. In serum, both IGF-I and -11 concentrations fell markedly in response to fasting. Serum IGF-I1 levels were linearly related to caloric intake in the pooled data from all groups. Concentrations of IGF-11, but not IGF-I, in liver and brain were depressed by caloric restriction. In contrast to the fall in IGF concentrations, activity of IGF-associated binding proteins rose in serum and in liver cytosol 2-to 4-fold in response to decreased nutrient intake. In serum, but not liver, the rise in binding protein activity was inversely related to caloric intake. In liver cytosol, but not serum, the rise in binding protein activity was inversely related to total serum amino acid concentration. Thus, IGF concentrations in preweanling rats change in response to alterations of nutrient intake. The fasting induced decrements in IGF levels, as well as the elevations in IGF-associated binding protein activity, may serve as a protective mechanism to depress growth in times of caloric restriction. (Pediatr Res 26: 128-134,1989) Abbreviations CON, control SAL, normal saline GLU, glucose GA, glucose and amino acids GAL, glucose, amino acids, and lipid RRA, radioreceptor assay HSA, human serum albumin GH, growth hormone

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Regulation of Somatomedin-C/Insulin-Like Growth Factor I by Nutrients

Cited by 127 publications

References 15 publications

Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting

Leptin alters the response of the growth hormone releasing factor- growth hormone--insulin-like growth factor-I axis to fasting

Marked differences in the IGF system that are associated with migration in comparable populations of Gujaratis living in Sandwell, UK, and Gujarat, India

The Effects of Altered Nutritional Status upon Insulin-Like Growth Factors and their Binding Proteins in Neonatal Rats

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