2017
DOI: 10.1073/pnas.1617270114
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Regulation of spinogenesis in mature Purkinje cells via mGluR/PKC-mediated phosphorylation of CaMKIIβ

Abstract: Dendritic spines of Purkinje cells form excitatory synapses with parallel fiber terminals, which are the primary sites for cerebellar synaptic plasticity. Nevertheless, how density and morphology of these spines are properly maintained in mature Purkinje cells is not well understood. Here we show an activity-dependent mechanism that represses excessive spine development in mature Purkinje cells. We found that CaMKIIβ promotes spine formation and elongation in Purkinje cells through its F-actin bundling activit… Show more

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Cited by 29 publications
(20 citation statements)
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References 58 publications
(71 reference statements)
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“…Ca 2+ may bind to synaptotagmin to trigger synaptic vesicle release (Emptage et al, 2001). Ca 2+ also binds to calmodulin (CaM) to form CaM-Ca 2+ complex, activating Ca 2+ /CaM-dependent protein kinases (CAMKs) or the Ca 2+ /CaM-dependent serine/threonine phosphatase calcineurin, which plays an important role in the regulation of synaptic plasticity (Yakel, 1997;Wayman et al, 2008;Kim et al, 2016;Sugawara et al, 2017). Ca 2+ activates the FIGURE 5 | E2 and G-1 stimulate phosphorylation of MOR in a PKC-dependent manner.…”
Section: Discussionmentioning
confidence: 99%
“…Ca 2+ may bind to synaptotagmin to trigger synaptic vesicle release (Emptage et al, 2001). Ca 2+ also binds to calmodulin (CaM) to form CaM-Ca 2+ complex, activating Ca 2+ /CaM-dependent protein kinases (CAMKs) or the Ca 2+ /CaM-dependent serine/threonine phosphatase calcineurin, which plays an important role in the regulation of synaptic plasticity (Yakel, 1997;Wayman et al, 2008;Kim et al, 2016;Sugawara et al, 2017). Ca 2+ activates the FIGURE 5 | E2 and G-1 stimulate phosphorylation of MOR in a PKC-dependent manner.…”
Section: Discussionmentioning
confidence: 99%
“…PKCg regulates spinogenesis and the morphology of the spines of distal dendrites through the phosphorylation of CaMKIIb (Sugawara et al, 2017). Purkinje cells in DGKg KO mice showed retracted distal dendrites, but the basic electrophysiological properties of PFs were normal, indicating that DGKg KO mice retained basic excitatory circuitry.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, in Purkinje cells, CaMKIIβ promotes spine formation and elongation via its F-actin bundling activity [ 45 ]. In addition, protein kinase C (PKC)-mediated phosphorylation of CaMKIIβ is responsible for the maintenance of the appropriate spine density and morphology in these cells.…”
Section: Camkiiβ In Neuronal Developmentmentioning
confidence: 99%
“…In addition, protein kinase C (PKC)-mediated phosphorylation of CaMKIIβ is responsible for the maintenance of the appropriate spine density and morphology in these cells. More precisely, PKC phosphorylates CaMKIIβ at S315 under the control of group I metabotropic glutamate receptor (mGluR1) signaling, and this event results in dissociation of the CaMKIIβ/F-actin complex, which then represses excessive spine formation and elongation in mature Purkinje cells [ 45 ].…”
Section: Camkiiβ In Neuronal Developmentmentioning
confidence: 99%