Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues

Gosmain, Yvan; Dif, Nicolas; Berbe, V.; Loizon, Emmanuelle; Rieusset, Jennifer; Vidal, Hubert; Lefai, Étienne

doi:10.1194/jlr.m400261-jlr200

Cited by 101 publications

(100 citation statements)

References 53 publications

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“…The present study provides the first evidence that rapamycin inhibits the post-prandial induction of GK enzyme at molecular and activity levels in trout liver, suggesting that GK and FAS activity may be controlled at a transcriptional level in a TORC1-dependent manner. This is consistent with our previous finding in rainbow trout hepatocytes (Lansard et al, 2010) and investigations in mammals (Düvel et al, 2010;Gosmain et al, 2005). How TORC1 regulates GK is quite complex: SREBP1c gene expression is involved in the regulation of lipid metabolism and also controls the expression of glucose metabolism-related genes, such as glucokinase and hexokinase-2 (HKII) in different tissues and cellular models (Ferré and Foufelle, 2007;Foufelle and Ferré, 2002;Gosmain et al, 2005).…”

Section: Glucose Metabolismsupporting

confidence: 81%

“…This is consistent with our previous finding in rainbow trout hepatocytes (Lansard et al, 2010) and investigations in mammals (Düvel et al, 2010;Gosmain et al, 2005). How TORC1 regulates GK is quite complex: SREBP1c gene expression is involved in the regulation of lipid metabolism and also controls the expression of glucose metabolism-related genes, such as glucokinase and hexokinase-2 (HKII) in different tissues and cellular models (Ferré and Foufelle, 2007;Foufelle and Ferré, 2002;Gosmain et al, 2005). Other investigations demonstrate that TORC1 increases glycolysis by activating the transcription and translation of HIF1a (Düvel et al, 2010;Majumder et al, 2004), a positive regulator of many glycolytic genes.…”

Section: Glucose Metabolismsupporting

confidence: 81%

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Postprandial regulation of hepatic glucokinase and lipogenesis requires the activation of TORC1 signaling in rainbow trout (Oncorhynchus mykiss)

Dai

Panserat

Mennigen

et al. 2013

Journal of Experimental Biology

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SUMMARYTo assess the potential involvement of TORC1 (target of rapamycin complex 1) signalling in the regulation of post-prandial hepatic lipid and glucose metabolism-related gene expression in trout, we employed intraperitoneal administration of rapamycin to achieve an acute inhibition of the TOR pathway. Our results reveal that rapamycin inhibits the phosphorylation of TORC1 and its downstream effectors (S6K1, S6 and 4E-BP1), without affecting Akt and the Akt substrates Forkhead-box Class O1 (FoxO1) and glycogen synthase kinase 3α/β (GSK 3α/β). These results indicate that acute administration of rapamycin in trout leads to the inhibition of TORC1 activation. No effect is observed on the expression of genes involved in gluconeogenesis, glycolysis and fatty acid oxidation, but hepatic TORC1 inhibition results in decreased sterol regulatory element binding protein 1c (SREBP1c) gene expression and suppressed fatty acid synthase (FAS) and glucokinase (GK) at gene expression and activity levels, indicating that FAS and GK activity is controlled at a transcriptional level in a TORC1-dependent manner. This study demonstrates for the first time in fish that post-prandial regulation of hepatic lipogenesis and glucokinase in rainbow trout requires the activation of TORC1 signalling.

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Section: Glucose Metabolismsupporting

confidence: 81%

Section: Glucose Metabolismsupporting

confidence: 81%

Postprandial regulation of hepatic glucokinase and lipogenesis requires the activation of TORC1 signaling in rainbow trout (Oncorhynchus mykiss)

Dai

Panserat

Mennigen

et al. 2013

Journal of Experimental Biology

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“…Pedersen et al 50 showed that members of the Sp and CREB families bind to the HKII promoter in hepatoma cells and, in insulin-responsive tissues, SREBP-1 also appears to be a regulator. 51 Whether these transcriptional factors provide a link to PI3-kinase remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells

Lee

States

2006

Cell Death Differ

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Colony-stimulating factor-1 (CSF-1) is essential for macrophage growth, differentiation and survival. Myeloid cells expressing a CSF-1 receptor mutant (DKI) show markedly impaired CSF-1-mediated proliferation and survival, accompanied by absent signal transducers and activators of transcription 3 (Stat3) phosphorylation and reduced PI3-kinase/Akt activity. Restoring phosphatidylinositol 3-kinase (PI3-kinase) but not Stat3 signals reverses the mitogenic defect. CSF-1-induced proliferation and survival are sensitive to glycolytic inhibitors, 2-deoxyglucose and 3-bromopyruvate. Consistent with a critical role for PI3-kinase-regulated glycolysis, DKI cells reconstituted with active PI3-kinase or Akt are hypersensitive to these inhibitors. CSF-1 upregulates hexokinase II (HKII) expression through PI3-kinase, and PI3-kinase transcriptionally activates the HKII promoter. Moreover, HKII overexpression partially restores mitogenicity. In contrast, Bcl-x L expression does not enhance long-term proliferation, although short-term cell death is suppressed in a glycolysis-independent manner. This study identifies robust PI3-kinase activation as essential for optimal CSF-1-mediated mitogenesis in myeloid cells, in part through regulation of HKII and support of glycolysis.

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“…SREBP-1c has been proposed as a major lipogenic transcription factor in various tissues including the pancreas [6]. Activation of SREBP-1c in response to various metabolic stimuli, including hyperinsulinemia, hyperglycemia and high FFA levels, results in the up-regulation of lipogenic genes [7,22]. The upregulation of this transcription factor in the pancreas was found in association with the accumulation of TG [6,23].…”

Section: Discussionmentioning

confidence: 89%

Rice bran water extract attenuates pancreatic abnormalities in high-fat diet-induced obese rats

Parklak¹,

Munkong²,

Somnuk³

et al. 2017

Trop. J. Pharm Res

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Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues

Cited by 101 publications

References 53 publications

Postprandial regulation of hepatic glucokinase and lipogenesis requires the activation of TORC1 signaling in rainbow trout (Oncorhynchus mykiss)

Postprandial regulation of hepatic glucokinase and lipogenesis requires the activation of TORC1 signaling in rainbow trout (Oncorhynchus mykiss)

Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells

Rice bran water extract attenuates pancreatic abnormalities in high-fat diet-induced obese rats

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