Regulation of stem cell fate by HSPGs: implication in hair follicle cycling

Colin-Pierre, Charlie; Baraka, Oussama El; Danoux, Louis; Bardey, Vincent; Andre, Valérie; Ramont, Laurent; Brézillon, Stéphane

doi:10.1038/s41536-022-00267-y

Cited by 9 publications

(5 citation statements)

References 256 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HSPGs are evolutionarily ancient subclass of proteoglycans which are composed of core protein and covalently attached HS glycosaminoglycan chains [27][28][29]. Based on their subcellular location, HSPGs are divided into three categories: extracellular HSPGs, exemplified by perlecan and type XVIII collagen; membranal HSPGs, represented by syndecans and glypicans; and the sole intracellular HSPG, serglycin [28,30,31]. HSPGs can bind to numerous bioactive molecular ligands, act as scaffolds for protein connections, and regulate receptor complexes formation by their HS chains [32,33].…”

Section: The Structure and Function Of Hspgs And Sulfsmentioning

confidence: 99%

6-O-endosulfatases in tumor metastasis: heparan sulfate proteoglycans modification and potential therapeutic targets

Han

2024

Am J Cancer Res

View full text Add to dashboard Cite

Metastasis is the leading cause of cancer-associated mortality. Although advances in the targeted treatment and immunotherapy have improved the management of some cancers, the prognosis of metastatic cancers remains unsatisfied. Therefore, the specific mechanisms in tumor metastasis need further investigation. 6-O-endosulfatases (SULFs), comprising sulfatase1 (SULF1) and sulfatase 2 (SULF2), play pivotal roles in the postsynthetic modifications of heparan sulfate proteoglycans (HSPGs). Consequently, these extracellular enzymes can regulate a variety of downstream pathways by modulating HSPGs function. During the past decades, researchers have detected the expression of SULF1 and SULF2 in most cancers and revealed their roles in tumor progression and metastasis. Herein we reviewed the metastasis steps which SULFs participated in, elucidated the specific roles and mechanisms of SULFs in metastasis process, and discussed the effects of SULFs in different types of cancers. Moreover, we summarized the role of targeting SULFs in combination therapy to treat metastatic cancers, which provided some novel strategies for cancer therapy.

show abstract

Section: The Structure and Function Of Hspgs And Sulfsmentioning

confidence: 99%

6-O-endosulfatases in tumor metastasis: heparan sulfate proteoglycans modification and potential therapeutic targets

Han

2024

Am J Cancer Res

View full text Add to dashboard Cite

show abstract

“…To activate one of the four cell surface FGFRs, paracrine FGFs bind with high affinity to heparan sulfate proteoglycan (HSPG) and require the presence of acetyl heparan sulfate in a synergistic manner ( 23 ). Typically, HSPG binds with FGFs at the β1–β2 loop and the extended β10–β12 region of FGFs.…”

Section: Fgf Signaling Axismentioning

confidence: 99%

Fibroblast growth factor signaling in macrophage polarization: impact on health and diseases

Shen,

Li,

Zhao

2024

Front. Immunol.

View full text Add to dashboard Cite

Fibroblast growth factors (FGFs) are a versatile family of peptide growth factors that are involved in various biological functions, including cell growth and differentiation, embryonic development, angiogenesis, and metabolism. Abnormal FGF/FGF receptor (FGFR) signaling has been implicated in the pathogenesis of multiple diseases such as cancer, metabolic diseases, and inflammatory diseases. It is worth noting that macrophage polarization, which involves distinct functional phenotypes, plays a crucial role in tissue repair, homeostasis maintenance, and immune responses. Recent evidence suggests that FGF/FGFR signaling closely participates in the polarization of macrophages, indicating that they could be potential targets for therapeutic manipulation of diseases associated with dysfunctional macrophages. In this article, we provide an overview of the structure, function, and downstream regulatory pathways of FGFs, as well as crosstalk between FGF signaling and macrophage polarization. Additionally, we summarize the potential application of harnessing FGF signaling to modulate macrophage polarization.

show abstract

“…Several excellent reviews on extracellular and cell surface HS–PGs exist in the literature. The interested reader is referred to these for further information [ 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 ]. In this review, the more important aspects of HS interactive components with representative examples of HS–PGs, such as perlecan and the syndecan, will be covered.…”

Section: Hs Interactive Proteinsmentioning

confidence: 99%

The Glycosaminoglycan Side Chains and Modular Core Proteins of Heparan Sulphate Proteoglycans and the Varied Ways They Provide Tissue Protection by Regulating Physiological Processes and Cellular Behaviour

Farrugia,

Melrose

2023

IJMS

View full text Add to dashboard Cite

This review examines the roles of HS–proteoglycans (HS–PGs) in general, and, in particular, perlecan and syndecan as representative examples and their interactive ligands, which regulate physiological processes and cellular behavior in health and disease. HS–PGs are essential for the functional properties of tissues both in development and in the extracellular matrix (ECM) remodeling that occurs in response to trauma or disease. HS–PGs interact with a biodiverse range of chemokines, chemokine receptors, protease inhibitors, and growth factors in immune regulation, inflammation, ECM stabilization, and tissue protection. Some cell regulatory proteoglycan receptors are dually modified hybrid HS/CS proteoglycans (betaglycan, CD47). Neurexins provide synaptic stabilization, plasticity, and specificity of interaction, promoting neurotransduction, neurogenesis, and differentiation. Ternary complexes of glypican-1 and Robbo–Slit neuroregulatory proteins direct axonogenesis and neural network formation. Specific neurexin–neuroligin complexes stabilize synaptic interactions and neural activity. Disruption in these interactions leads to neurological deficits in disorders of functional cognitive decline. Interactions with HS–PGs also promote or inhibit tumor development. Thus, HS–PGs have complex and diverse regulatory roles in the physiological processes that regulate cellular behavior and the functional properties of normal and pathological tissues. Specialized HS–PGs, such as the neurexins, pikachurin, and Eyes-shut, provide synaptic stabilization and specificity of neural transduction and also stabilize the axenome primary cilium of phototoreceptors and ribbon synapse interactions with bipolar neurons of retinal neural networks, which are essential in ocular vision. Pikachurin and Eyes–Shut interactions with an α-dystroglycan stabilize the photoreceptor synapse. Novel regulatory roles for HS–PGs controlling cell behavior and tissue function are expected to continue to be uncovered in this fascinating class of proteoglycan.

show abstract

Regulation of stem cell fate by HSPGs: implication in hair follicle cycling

Cited by 9 publications

References 256 publications

6-O-endosulfatases in tumor metastasis: heparan sulfate proteoglycans modification and potential therapeutic targets

6-O-endosulfatases in tumor metastasis: heparan sulfate proteoglycans modification and potential therapeutic targets

Fibroblast growth factor signaling in macrophage polarization: impact on health and diseases

The Glycosaminoglycan Side Chains and Modular Core Proteins of Heparan Sulphate Proteoglycans and the Varied Ways They Provide Tissue Protection by Regulating Physiological Processes and Cellular Behaviour

Contact Info

Product

Resources

About