Regulation of striatal serotonin release by the lateral habenula-dorsal raphe pathway in the rat as demonstrated by in vivo microdialysis: role of excitatory amino acids and GABA

Kalén, Peter; Strecker, Robert E.; Rosengren, E.; Björklund, Anders

doi:10.1016/0006-8993(89)90901-3

Cited by 122 publications

(64 citation statements)

References 64 publications

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“…Hippocampal 5-hydroxyindole acetic acid (5-HIAA) was increased after microinjection of bicuculline or picrotoxin into the MRN (Forchetti & Meek, 1981). Similarly, striatal 5-HT was increased during microinfusion of bicuculline into the DRN (Kalen et al, 1989), but others found no change in forebrain 5-HT metabolism or release in response to GABAA receptor blockade in the DRN (Reisine et al, 1982;Nishikawa & Scatton, 1983). The present results suggest that GABAA receptors on 5-HT neurones in the DRN were tonically activated.…”

Section: Tonic Inhibitory Control Of 5-ht Neuronal Activitymentioning

confidence: 57%

“…However, we are not aware of any other experimental evidence that would support this hypothesis. Other unresolved issues concerning local circuitry include the extent to which inhibitory synapses on raphe 5-HT neurones involve GABAergic interneurones (Belin et al, 1979;Wang et al, 1992) or afferents from other sites such as pontine reticular formation and lateral habenula (Wang et al, 1976;Wang & Aghajanian, 1977;Nishikawa & Scatton, 1985a;Kalen et al, 1989).…”

Section: Effect Of Gabab Receptor Stimulationmentioning

confidence: 99%

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Differential regulation of 5‐hydroxytryptamine release by GABA_A and GABA_B receptors in midbrain raphe nuclei and forebrain of rats

Tao

Auerbach

1996

British J Pharmacology

143

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1 Extracellular 5-hydroxytryptamine (5-HT) was determined in dorsal raphe nucleus (DRN), median raphe nucleus (MRN) and nucleus accumbens by use of microdialysis in unanaesthetized rats. 2 Infusion of the y-aminobutyric acid (GABA)A receptor agonist muscimol into DRN and MRN resulted in decreased 5-HT in DRN and MRN, respectively. Muscimol infusion into nucleus accumbens had no effect on 5-HT. 3 Infusion of the GABAA receptor antgonist bicuculline into DRN resulted in increased DRN and nucleus accumbens 5-HT. Bicuculline infusion into MRN had no effect on 5-HT. This suggests that endogenous GABA had a tonic, GABAA receptor-mediated inhibitory effect on 5-HT in DRN, but not in MRN. 4 Infusion of the GABAB receptor agonist baclofen into DRN produced a decrease in DRN 5-HT. Baclofen infusion into nucleus accumbens resulted in decreased nucleus accumbens 5-HT. This suggests that GABAB receptors are present in the area of cell bodies and terminals of 5-hydroxytryptaminergic neurones.5 Infusion of the GABAB receptor antagonists phaclofen and 2-hydroxysaclofen had no effect on midbrain raphe and forebrain 5-HT. This suggests that GABAB receptors did not contribute to tonic inhibition of 5-HT release. 6 In conclusion, 5-HT release is physiologically regulated by distinct subtypes of GABA receptors in presynaptic and postsynaptic sites.

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Section: Tonic Inhibitory Control Of 5-ht Neuronal Activitymentioning

confidence: 57%

Section: Effect Of Gabab Receptor Stimulationmentioning

confidence: 99%

Differential regulation of 5‐hydroxytryptamine release by GABA_A and GABA_B receptors in midbrain raphe nuclei and forebrain of rats

Tao

Auerbach

1996

British J Pharmacology

143

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“…Five days later, the septal-diagonal band area was dissected out from 15-to 16-day rat fetuses of the same outbred strain and grafted to the previously lesioned rats either into the cavity produced by the FF lesion (one bilateral septaldiagonal band area per recipient; n = 16) or as a cell suspension (7) stereotaxically injected into the ipsilateral hippocampal formation (n = 17) at the following coordinates: (i) A = -4.5 (behind bregma), L = 3.5 (from the midline), V = 3.0 (ventral to dura); (ii) A = -6.0, L = 5.0, V = 5.0. The incisor bar was set at zero level and 1.5 ,u1 of suspension was injected at each site.…”

Section: Methodsmentioning

confidence: 99%

Acetylcholine release from intrahippocampal septal grafts is under control of the host brain.

Nilsson

Kalén

Rosengren

et al. 1990

Proc. Natl. Acad. Sci. U.S.A.

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The activity of intrahippocampal transplants of cholinergic neurons was monitored by microdialysis in awake, freely moving rats. Fetal septal-diagonal band tissue was implanted into rats with a complete transection of the fimbria-fornix cholinergic pathway either as a cell suspension injected into the hippocampus or as a solid graft implanted in the lesion cavity. The grafts restored baseline acetylcholine release in the graft-reinnervated hippocampus to normal or supranormal levels. The graft-derived acetylcholine release was dependent on intact axonal impulse flow, and it was markedly increased during behavioral activation by sensory stimulation or by electrical stimulation of the lateral habenula. The results demonstrate that the septal grafts, despite their ectopic location, can become functionally integrated with the host brain and that the activity of the transplanted cholinergic neurons can be modulated from the host brain during ongoing behavior. Anatomical observations, using immunohistochemistry and retrograde tracing, indicate that direct or indirect brainstem afferents to the graft could mediate this functional integration. Host afferent control of the graft may thus play a role in the recovery of lesion-induced functional deficits seen with these types of transplants.Previous behavioral and electrophysiological studies have shown that grafts of fetal cholinergic-rich tissue can restore at least some aspects of normal function in rats with lesions of the septohippocampal cholinergic pathway (1, 2). These results raise the question as to the mechanism(s) of action underlying graft-induced functional recovery in the subcortically deafferented hippocampus. While available data indicate that such grafts can restore synaptic cholinergic neurotransmission in the previously denervated target, it remains unclear to what extent they can become functionally integrated with the host neuronal circuitry.In the intact animal, the activity of the septohippocampal cholinergic neurons is known to change with alterations in ongoing behavior and in response to arousing or behaviorally activating stimuli (3-5). Hippocampal activation, as reflected in the induction of theta rhythm in the hippocampal electroencephalogram, depends on the integrity of the septohippocampal connections, and lesions of the septohippocampal cholinergic pathway by fimbria-fornix (FF) transection or medial septal lesions are known to remove a principal route for subcortical activation ofthe hippocampal formation (1, 5).In the present study, we have used the intracerebral microdialysis technique to monitor acetylcholine (AcCho) release in the subcortically denervated hippocampus reinnervated by fetal septal solid or suspension grafts. The experiment was performed in awake, freely moving rats both under baseline conditions and during behavioral activation of types that are known to induce AcCho release from intact septohippocampal cholinergic neurons (3, 4). METHODSYoung adult female Sprague-Dawley rats (ALAB, Stockholm) were given a unilat...

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“…duboka moždana stimulacija habenule, postavljanjem elektroda u stria medullaris, glavni limbički aferentni snop habenule, rezultirala je otklanjanjem simptoma depresije, odnosno remisijom kod pacijenata rezistentnih na sve ostale oblike terapije (69). Potvrđena je funkcionalna modulacija striae medullaris, kao i porast koncentracije norepinefrina u hipokampusu i medijalnom prefrontalnom korteksu, kao i serotonina u striatumu (70)(71)(72). Pretpostavlja se da visokofrekventna duboka moždana stimulacija povećava oslobađanje inhibitornih neurotransmitera iz presinaptičkih neurona (73), što smanjuje aktivnost jedara habenule i njihov inhibitorni uticaj na monoaminergičke neurone (41).…”

Section: Kontrola Sistema Zadovoljstva I Motornog Odgovoraunclassified

10.5937/mckg48-5899 = Functional and anatomical aspects of the habenular complex of epithalamus

Marković¹,

Ognjanović²

2014

Medicinski casopis

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UVODepitalamus (epithalamus) predstavlja deo međumozga, smešten na dorzokaudalnom delu talamusa i po svojoj anatomskoj poziciji, ali i neuronskim vezama predstavlja "raskrsnicu" na kojoj se ukrštaju putevi limbičkog sistema, bazalnih ganglija, ali i mnogi drugi neuronski krugovi. Morfološki gledano sastoji se iz epifize (gl. pinealis), habenularnih jedara (nuclei habenulae), međuhabenularne spojnice (commisura habenularum) i striae medularis. Habenularni kompleks je parna struktura epitalamusa, sastavljena iz dva jedra -medijalnog (nc. habenularis medialis -MHb) i lateralnog (nc. habenularis lateralis -lHb). to je filogenetski stara moždana struktura sa kod većine kičmenjaka jasno uočljivom asimetrijom u veličini kompleksa desne i leve strane (1). Medijalno jedro habenule izgrađeno je od gusto pakovanih nervnih ćelija koje su na osnovu svojih citoarhitektonskih karakteristika svrstane u pet subnukleusa (2), dok se u okviru lateralnog habenularnog jedra opisuje 10 subnukleusa (3). anatomska lokalizacija i veze omogućavaju jedrima habenule ulogu u regulaciji mnoštva fizioloških mehanizama, ali i u patogenezi pojedinih bolesti, kao što su depresija, shizofrenija, Parkinsonova bolest, bolesti zavisnosti i dr. (4). u ovom radu prikazuju se nova saznanja o ulozi habenularnog kompleksa u normalnim, fiziološkim procesima, kao i patogenezi psihijatrijskih oboljenja. NEURONSKE VEZE HABENULARNOG KOMPLEKSAHabenularni kompleks predstavlja glavnu vezu između bazalnih ganglija i limbičkih delova telencefalona, s jedne

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Regulation of striatal serotonin release by the lateral habenula-dorsal raphe pathway in the rat as demonstrated by in vivo microdialysis: role of excitatory amino acids and GABA

Cited by 122 publications

References 64 publications

Differential regulation of 5‐hydroxytryptamine release by GABA_A and GABA_B receptors in midbrain raphe nuclei and forebrain of rats

Differential regulation of 5‐hydroxytryptamine release by GABA_A and GABA_B receptors in midbrain raphe nuclei and forebrain of rats

Acetylcholine release from intrahippocampal septal grafts is under control of the host brain.

10.5937/mckg48-5899 = Functional and anatomical aspects of the habenular complex of epithalamus

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Regulation of striatal serotonin release by the lateral habenula-dorsal raphe pathway in the rat as demonstrated by in vivo microdialysis: role of excitatory amino acids and GABA

Cited by 122 publications

References 64 publications

Differential regulation of 5‐hydroxytryptamine release by GABAA and GABAB receptors in midbrain raphe nuclei and forebrain of rats

Differential regulation of 5‐hydroxytryptamine release by GABAA and GABAB receptors in midbrain raphe nuclei and forebrain of rats

Acetylcholine release from intrahippocampal septal grafts is under control of the host brain.

10.5937/mckg48-5899 = Functional and anatomical aspects of the habenular complex of epithalamus

Contact Info

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Differential regulation of 5‐hydroxytryptamine release by GABA_A and GABA_B receptors in midbrain raphe nuclei and forebrain of rats

Differential regulation of 5‐hydroxytryptamine release by GABA_A and GABA_B receptors in midbrain raphe nuclei and forebrain of rats