Regulation of Swine Growth by Backfat Tissue during Growing and Finishing Stages

Seo, Y. M.; Lim, Bee-Oh; Kim, Doyoung; Lim, Kyu-Sang; Kim, Junmo

doi:10.3390/ani11123511

Cited by 2 publications

(1 citation statement)

References 47 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Backfat thickness (BFT) is an important carcass composition trait and influences growth, which is why it is regarded as a breeding focus [ 1 , 2 , 3 ]. Due to the importance of BFT, it has been extensively studied, and some important regulatory genes have been found [ 4 , 5 , 6 ]. GLI pathogenesis-related 1 ( GLIPR1 ) was identified as a candidate gene by transcriptome analysis of pig BFT in our previous study [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Expression and Genetic Effects of GLI Pathogenesis-Related 1 Gene on Backfat Thickness in Pigs

Liu

Zhang

et al. 2022

Genes

View full text Add to dashboard Cite

Backfat thickness (BFT) is an important carcass composition trait and regarded as a breeding focus. Our initial transcriptome analysis of pig BFT identified GLI pathogenesis-related 1 (GLIPR1) as one of the promising candidate genes. This study was conducted to identify the expression profiles, polymorphisms, and genetic effects of the GLIPR1 gene on BFT in pigs. The expression of the GLIPR1 gene existed in every detected tissue, and there was a significantly higher expression in spleen and adipose tissue than others (p < 0.05). At the different ages of pig, the expression of the GLIPR1 gene was low at an early age, increased with growth, and reached the highest level at 180 days. Genetic polymorphism analysis was detected in 553 individuals of the Large White × Minzhu F2 population. Four SNPs in the promoter significantly associated with 6–7 rib BFT (p < 0.05) were predicted to alter the transcription factor binding sites (TFBS), and the mutations of g.38758089 T > G and g.38758114 G > C were predicted to change the TFs associated with the regulation of adipogenesis. Haplotypes were formed by the detected SNPs, and one block showed a strong association with BFT (p < 0.05). In summary, our results indicate that the expression profiles and genetic variants of GLIPR1 affected the BFT of pigs. To our knowledge, this study is the first to demonstrate the biological function and genetic effects of the GLIPR1 gene on the BFT of pig and provide genetic markers to optimize breeding for BFT in pigs.

show abstract

Section: Introductionmentioning

confidence: 99%

Expression and Genetic Effects of GLI Pathogenesis-Related 1 Gene on Backfat Thickness in Pigs

Liu

Zhang

et al. 2022

Genes

View full text Add to dashboard Cite

show abstract

Transcriptomic profiling of backfat and muscle in Lijiang pigs with divergent body size across growth stages

Fang,

Luo,

Jin

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Backfat thickness is an important economic trait that affects pork quality and flavor. The Lijiang pig (LJP), a local breed in Yunnan province, China, exhibits variations in growth and body composition. However, the molecular basis for these variations is unclear. This study aimed to analyze transcriptome profiles of backfat at different growth stages in LJP with discrepant body size: two months (M2), four months, and six months. Firstly, we analyzed the gene expression differences and discovered a significantly highest number of differentially expressed genes (DEGs) at the M2 stage. Secondly, we identified four gene profiles with reverse expression trends in LJP populations with different body sizes, and the related genes mainly associated with immune response functionality. Thirdly, we observed a lower correlation in LJP with large body size at the M2 stage, with a specific enrichment of DEGs with high genetic differentiation related to neural activity. Finally, we correlated transcriptome profiles of muscle and backfat and discovered the lowest correlation at the M2 stage. Highly correlated genes exhibited more significant differences and were prominently enriched for immune response processes. This study unveils candidate genes linked to backfat growth in LJP, emphasizing the specificity of the early growth stage of backfat. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-78054-6.

show abstract

Regulation of Swine Growth by Backfat Tissue during Growing and Finishing Stages

Cited by 2 publications

References 47 publications

Expression and Genetic Effects of GLI Pathogenesis-Related 1 Gene on Backfat Thickness in Pigs

Expression and Genetic Effects of GLI Pathogenesis-Related 1 Gene on Backfat Thickness in Pigs

Transcriptomic profiling of backfat and muscle in Lijiang pigs with divergent body size across growth stages

Contact Info

Product

Resources

About