Regulation of T cell Apoptosis during the Immune Response

Baumann, Sven; Krueger, Andreas; Kirchhoff, Sabine; Krammer, Peter H.

doi:10.2174/1566524024605671

Cited by 93 publications

(71 citation statements)

References 193 publications

(238 reference statements)

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“…The programmed death of T lymphocytes in the early stage of LM infection is independent of signaling through Fas, TNF, and IFN-␥ receptors (7) and thus differs from classical activation-induced cell death (AICD) (8). AICD is responsible for the elimination of Ag-specific effector cells at the end of an immune response (the contraction phase).…”

Section: Selective Depletion Of Nonspecific T Cells During the Earlymentioning

confidence: 99%

Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection

Jiang

Lau

Shen

2003

The Journal of Immunology

111

107

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Transient T cell depletion occurs before the development of an effective immune response to infection. In this study we show that most T cells, regardless of specificity, are induced to express early activation markers soon after infection with Listeria monocytogenes or lymphocytic choriomeningitis virus. Ag-specific T cells are further activated to display late activation markers and undergo extensive proliferation. As Ag-specific T cells begin to expand, nonspecific T cells are depleted en masse and exhibit no sign of further activation or proliferation before their depletion. This selective depletion of nonspecific T cells is due to in situ death via apoptosis, as visualized by confocal microscopy. Thus, early activation and subsequent depletion of nonspecific T cells are integral parts of the immune response to proinflammatory infections. These results have important implications for our understanding of early events in the development of a robust T cell response.

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Section: Selective Depletion Of Nonspecific T Cells During the Earlymentioning

confidence: 99%

Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection

Jiang

Lau

Shen

2003

The Journal of Immunology

111

107

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“…2,4,5 It is well documented that AICD in peripheral T-cells is mediated through Fas and FasL interaction, and is believed to function as limitation overexpansion of an immune response by eliminating unwanted lymphocytes and elimination autoreactive T-cells during thymic selection. 6 Similar to many cellular cascades, the Fas/ FasL pathway is policed by numerous mediators. Regulation of Fas-mediated apoptosis may occur at many steps along the recruitment-activation pathway.…”

Section: Introductionmentioning

confidence: 99%

Let-7/miR-98 regulate Fas and Fas-mediated apoptosis

Tang

Cui

et al. 2011

Genes Immun

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Fas is ubiquitously expressed on a variety of cells and triggers apoptosis, which have critical roles in the immune system. MicroRNAs (miRNAs) have been recently identified as regulators that modulate target gene expression and are involved in diverse biological processes, such as cell proliferation and apoptosis. This study was undertaken to investigate the contribution of miRNA in the regulation of Fas expression and Fas-mediated apoptosis. Bioinformatics analysis indicated that Fas was a potential target of let-7/miR-98 family. Indeed ectopic expression of let-7/miR-98 reduced, whereas knockdown of endogenous let-7/miR-98 increased the expression of Fas at both mRNA and protein levels. Let-7/miR-98 was verified to target Fas 3 0 untranslated region directly by site-directed gene mutagenesis and reporter gene assay. More importantly, introduction of let-7/miR-98 could decrease the sensitivity to Fas-induced apoptosis. Furthermore, let-7/miR-98 expression was reduced in activation-induced cell death process, accompanied by increased expression of Fas. In conclusion, our study first demonstrated that let-7/miR-98 regulated Fas expression and the sensitivity of Fas-mediated apoptosis.

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“…The balance between cell growth and apoptosis is particularly critical in the immune response. In response to antigen stimulation, T cells not only express cytokines necessary for autocrine proliferation but also undergo an apoptotic process known as activation-induced cell death (AICD) (reviewed in Baumann et al, 2002). This dual response averts the dangers of uncontrolled lymphocyte proliferation, while at the same time supporting a level of lymphocyte expansion that suffices for immune defense.…”

Section: Introductionmentioning

confidence: 99%

TID1, a mammalian homologue of the drosophila tumor suppressor lethal(2) tumorous imaginal discs, regulates activation-induced cell death in Th2 cells

et al. 2003

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We previously described two human DnaJ proteins, hTid-1 L and hTid-1 S , which are derived from alternative splicing of the TID1 gene, the human homologue of the Drosophila tumor suppressor lethal(2) tumorous imaginal discs, and showed that hTid-1 L promoted while hTid-1 S antagonized apoptosis. There are two subsets of helper T cells, Th1 and Th2, of which Th2 cells are significantly less prone to apoptosis induced by stimulation through the T-cell receptor. This apoptotic process is known as activation-induced cell death (AICD). The molecular basis for the differential susceptibility of Th1 and Th2 cells to AICD is not known. Here we show that the antiapoptotic variant, Tid-1 S , is selectively induced in murine Th2 cells following activation. Expression of a dominant-negative mutant of hTid-1 S in a Th2 cell line strikingly enhanced activation of caspase 3 in response to CD3 stimulation, and caused the cells to become sensitive to AICD. Hence, the accumulation of Tid-1 S in Th2 cells following activation represents a novel mechanism that may contribute to the induction of apoptosis resistance during the activation of Th2 cells.

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Regulation of T cell Apoptosis during the Immune Response

Cited by 93 publications

References 193 publications

Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection

Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection

Let-7/miR-98 regulate Fas and Fas-mediated apoptosis

TID1, a mammalian homologue of the drosophila tumor suppressor lethal(2) tumorous imaginal discs, regulates activation-induced cell death in Th2 cells

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