Regulation of TH1/TH2 Cytokine Production by Chungsim-Yeunja-Tang in Patients with Cerebral Infarction

Abstract

Chungsim-Yeunja-Tang is a prescription for the Taeumin cerebral infarction (CI) patients according to Sasang constitutional philosophy. Taeumin patients with CI were treated with CY-Tang during the acute stage. Clinical signs of CI disappeared markedly in about 2 weeks after oral administration of CY-Tang in all patients. The mean interleukin (IL)-2 plasma levels were slightly lower in the patients with CI than in the normal groups, whereas the mean TNF-alpha, IL-4, IL-6, and IgE levels were significantly higher in the patients with CI. There were no significant differences in interferon-gamma (IFN-gamma) levels between the groups. Serum IFN-gamma and IL-2 levels derived from (Th) 1 cells were significantly elevated in the patients with CI by CY-Tang administration. Significant reduced plasma levels of IL-4 and IL-6 derived from Th2 cells and IgE were observed in the patients treated with CY-Tang. Plasma levels TNF-alpha derived from Th1 significantly increased in the patients treated with CY-Tang. During the period of CY-Tang administration, there were no other adverse effects. The data indicate that CY-Tang has a good CI treatment effect, and that its action may be due to the regulation of cytokine production.

The In Vivo Effects of Cytokines Modulation for BALB/C Mice Fed with a Traditional Combined Chinese Herb‐Soaked Solution, Yi‐Fey Ruenn‐Hou Tea

“…[7] Chungsim-Yeunja-Tang, an herb prescription, was reported to have a good cerebral infarction treatment effect, and that its action may be due to the regulation of cytokine production. [8] On-Chung-Eum, a traditional plant medicine, has been used as treatment for Behçet's disease patients and may help the improvement of symptoms through cytokine modulation. [9] All components, licorice root, American ginseng, Radix Paeoniae alba and green tea, which were combined into YR Tea used in our study, have direct or indirect effects Figure 3.…”

Aspects of gene polymorphisms in cerebral infarction: inflammatory cytokines

“…However, although accumulating evidence suggests that inflammatory-mediated damage plays a role in brain ischemia, it remain unclear whether inflammation also intervenes in CI. In clinical studies, Jeong et al [113] reported that serum IL-2 levels, but not IFN-g, decreased significantly in the patients with CI compared with controls. In contrast they also reported that a significant increase of TNFa [114], IL-4 [115], IL-6 [115] and immunoglobulin E (IgE) [116] serum levels was observed in the patients with CI (table 1).…”

Physiome and Sasang Constitutional Medicine

“…The Questionnaire for Sasang Constitution Classification (QSCC) is a program widely used in this field, and it has been shown that physical constitution changes according to appearance, character, common symptoms, and reactions to certain foods. More than 30 papers have been published since 1991 in this field, and many scientific methodologies have been introduced from consultations with psychologists, Korean language experts, and statisticians [14][15][16][17][18][19][20][21].…”