Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3

Herrington, Felicity; Nibbs, Robert J. B.

doi:10.3390/cells5020014

Cited by 29 publications

(27 citation statements)

References 105 publications

(167 reference statements)

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“…Gene NFIL3 is believed to be associated with the function of adaptive immune lines and natural killer cell development (Seillet et al, 2014). Genes EGR1 (Carter et al, 2007), SOX10 (Fufa et al, 2015), and REL (Hayden and Ghosh, 2011;Herrington and Nibbs, 2016) were found to be associated with prereceptormediated differentiation of thymocytes, proliferation and survival of melanocytes and melanogenesis, and key regulation of inducible gene expression in the immune system, respectively. Table 2.…”

Section: Resultsmentioning

confidence: 99%

Genome-wide association studies for tick resistance in Bos taurus × Bos indicus crossbred cattle: A deeper look into this intricate mechanism

Otto

Guimarães

Verardo

et al. 2018

Journal of Dairy Science

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Rhipicephalus (Boophilus) microplus is the main cattle ectoparasite in tropical areas. Gir × Holstein crossbred cows are well adapted to different production systems in Brazil. In this context, we performed genome-wide association study (GWAS) and post-GWAS analyses for R. microplus resistance in an experimental Gir × Holstein F population. Single nucleotide polymorphisms (SNP) identified in GWAS were used to build gene networks and to investigate the breed of origin for its alleles. Tick artificial infestations were performed during the dry and rainy seasons. Illumina BovineSNP50 BeadChip (Illumina Inc., San Diego, CA) and single-step BLUP procedure was used for GWAS. Post-GWAS analyses were performed by gene ontology terms enrichment and gene transcription factors networks, generated from enriched transcription factors, identified from the promoter sequences of selected gene sets. The genetic origin of marker alleles in the F population was assigned using the breed of origin of alleles approach. Heritability estimates for tick counts were 0.40 ± 0.11 in the rainy season and 0.54 ± 0.11 in the dry season. The top ten 0.5-Mbp windows with the highest percentage of genetic variance explained by SNP markers were found in chromosomes 10 and 23 for both the dry and rainy seasons. Gene network analyses allowed the identification of genes involved with biological processes relevant to immune system functions (TREM1, TREM2, and CD83). Gene-transcription factors network allowed the identification of genes involved with immune functions (MYO5A, TREML1, and PRSS16). In resistant animals, the average proportion of animals showing significant SNPs with paternal and maternal alleles originated from Gir breed was 44.8% whereas the proportion of animals with both paternal and maternal alleles originated from Holstein breed was 11.3%. Susceptible animals showing both paternal and maternal alleles originated from Holstein breed represented 44.6% on average, whereas both paternal and maternal alleles originated from Gir breed animals represented 9.3%. This study allowed us to identify candidate genes for tick resistance in Gir × Holstein crossbreds in both rainy and dry seasons. According to the origin of alleles analysis, we found that most animals classified as resistant showed 2 alleles from Gir breed, while the susceptible ones showed alleles from Holstein. Based on these results, the identified genes may be thoroughly investigated in additional experiments aiming to validate their effects on tick resistance phenotype in cattle.

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Section: Resultsmentioning

confidence: 99%

Genome-wide association studies for tick resistance in Bos taurus × Bos indicus crossbred cattle: A deeper look into this intricate mechanism

Otto

Guimarães

Verardo

et al. 2018

Journal of Dairy Science

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“…The Ikaros family of transcription factors in mice activate lymphoid differentiation (Kim et al, 1999) and in mice, Ikzf2 expression is associated with a block in myeloid lineage differentiation (Park et al, 2019). Bcl3 regulates transcription by associating with NFκB and is important for B-cell proliferative responses and involved in T-helper cell differentiation (reviewed in (Herrington and Nibbs, 2016). The upregulation of these lymphoid program genes in gata2b -/-CD41:GFP low cells together with the forward and side scatter differences suggests a lymphoid bias in gata2b -/-HSPCs.…”

Section: Adult Gata2b -/Phenotypic Hspcs Show Upregulation Of Lymphoimentioning

confidence: 99%

Single cell transcriptome analysis reveals an essential role for Gata2b in hematopoietic lineage decisions in zebrafish

Gioacchino¹,

Koyunlar

Looper

et al. 2019

Preprint

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Hematopoietic stem cells (HSCs) are tightly controlled to maintain a balance between myeloid and lymphoid cell differentiation. Gata2 is a pivotal hematopoietic transcription factor required for HSC generation and maintenance. We generated a zebrafish mutant for the mouse Gata2 orthologue, gata2b. We found that in adult zebrafish, gata2b is required for both neutrophilic-and monocytic lineage differentiation. Single cell transcriptome analysis revealed that the myeloid defect present in Gata2b deficient zebrafish arise in the most immature hematopoietic stem and progenitor cell (HSPC) compartment and that this population is instead committed towards the lymphoid and erythroid lineage. Taken together, we find that Gata2b is vital for the fate choice between the myeloid and lymphoid lineages.

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“…In contrast, the powerful pro‐inflammatory gene TNF was one of the 6 transcripts downregulated by EVLP. Several of the most significantly upregulated genes are involved in the regulation of cellular proliferation and apoptosis (eg, BCL3 , CDKN1A , MYC ). Other important functional associations include roles in energy metabolism (eg, ARG2 , HK2 ), tissue remodeling (eg, F3 , SERPINE1 , TIMP1 ), and response to oxidative stress (eg, MT1A , MT2A , SOD2 ).…”

Section: Discussionmentioning

confidence: 99%

Ex vivo perfusion induces a time- and perfusate-dependent molecular repair response in explanted porcine lungs

Dromparis

Aboelnazar

Wagner

et al. 2019

American Journal of Transplantation

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Ex vivo lung perfusion (EVLP) shows promise in ameliorating pretransplant acute lung injury (ALI) and expanding the donor organ pool, but the mechanisms of ex vivo repair remain poorly understood. We aimed to assess the utility of gene expression for characterizing ALI during EVLP. One hundred sixty-nine porcine lung samples were collected in vivo (n = 25), after 0 (n = 11) and 12 (n = 11) hours of cold static preservation (CSP), and after 0 (n = 57), 6 (n = 8), and 12 (n = 57) hours of EVLP, utilizing various ventilation and perfusate strategies. The expression of 53 previously described ALI-related genes was measured and correlated with function and histology. Twenty-eight genes were significantly upregulated and 6 genes downregulated after 12 hours of EVLP. Aggregate gene sets demonstrated differential expression with EVLP (P < .001) but not CSP. Upregulated 28-gene set expression peaked after 6 hours of EVLP, whereas downregulated 6-gene set expression continued to decline after 12 hours. Cellular perfusates demonstrated a greater reduction in downregulated 6-gene set expression vs acellular perfusate (P < .038). Gene set expression correlated with relevant functional and histologic parameters, including P/F ratio (P < .001) and interstitial inflammation (P < .005). Further studies with posttransplant results are warranted to evaluate the clinical significance of this novel molecular approach for assessing organ quality during EVLP.

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Regulation of the Adaptive Immune Response by the IκB Family Protein Bcl-3

Cited by 29 publications

References 105 publications

Genome-wide association studies for tick resistance in Bos taurus × Bos indicus crossbred cattle: A deeper look into this intricate mechanism

Genome-wide association studies for tick resistance in Bos taurus × Bos indicus crossbred cattle: A deeper look into this intricate mechanism

Single cell transcriptome analysis reveals an essential role for Gata2b in hematopoietic lineage decisions in zebrafish

Ex vivo perfusion induces a time- and perfusate-dependent molecular repair response in explanted porcine lungs

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