Regulation of the expression of Th17 cells and regulatory T cells by IL-27 in patients with unexplained early recurrent miscarriage

Wang, Wen‐Juan; Liu, Fujun; Qu, Hongmei; Hao, Cuifang; Qu, Qinglan; Xiong-Wang,; Bao, Hongchu; Wang, Xinrong

doi:10.1016/j.jri.2013.04.002

Cited by 60 publications

(43 citation statements)

References 46 publications

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“…Several studies have demonstrated that T H 17 cell counts and proportions increased in a variety of autoimmune diseases such as autoimmune hemolytic anemia and immune thrombocytopenia [52], rheumatoid arthritis [53], psoriasis [54], and lupus [55]. However, Barbosa et al [15] found no increase in the frequency of T H 17 cells in CVID patients with autoimmune manifestations, even when CVID patients were subdivided based on the type of autoimmune disorder, including organ-specific autoimmunity and autoimmune cytopenias.…”

Section: Helper T-cell Defectsmentioning

confidence: 99%

T-Cell Abnormalities in Common Variable Immunodeficiency

Azizi

Rezaei

Kiaee

et al. 2016

J Investig Allergol Clin Immunol

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Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients. Key words: Common variable immunodeficiency. T cell. Helper T cells. Regulatory T cells. ResumenLa inmunodeficiencia común variable (CVID) es la inmunodeficiencia primaria más frecuente. Se caracteriza por un defecto en la diferenciación de linfocitos B hacia células plasmáticas y linfocitos B memoria. Se han descrito numerosas alteraciones en los linfocitos T de estos pacientes, tales como disminución en el número de linfocitos T y en sus respuestas proliferativas, aumento en la activación de células T y en la apoptosis, así como alteraciones en la producción de citokinas. El objetivo de esta revisión es describir las alteraciones funcionales y fenotípicas de los linfocitos T en los pacientes con CVID y revisar la bibliografía en relación a los efectos que la administración de inmunoglobulinas produce en los linfocitos T de los pacientes con CVID. Palabras clave: Inmunodeficiencia común variable. Células T. Células T helper. Células T reguladoras.

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Section: Helper T-cell Defectsmentioning

confidence: 99%

T-Cell Abnormalities in Common Variable Immunodeficiency

Azizi

Rezaei

Kiaee

et al. 2016

J Investig Allergol Clin Immunol

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“…Anti-inflammatory cytokines such as IL-10 appear to protect against inflammation-induced miscarriage (54). The TNF-α and IFN-γ are classified among the cytokines that are particularly detrimental to the survival of the fetus, while IL-4, IL-6 and IL-10 promote embryonic development When anti-TNF-α agents or antibodies were administered, fetal reabsorption rates and embryonic apoptosis were reduced in a murine model of immunologically mediated miscarriages (2, 37,55,56).The interaction between pro-and anti-inflammatory cytokinesseems to be the key factor throughout successful pregnancy, thus, it is fundamental to promote normal pregnancy outcomes.In other words the balance between inflammatory and antiinflammatory cytokines promotes normal pregnancy. On the hand however, the loss of elevated levels of pro-inflammatory cytokines and C-reactive protein (CRP), and decreased amounts of anti-inflammatory cytokines were reported to be associated with the occurrence of preeclampsia (PE) and premature labor (12).…”

Section: D] Cytokines Factormentioning

confidence: 99%

Review Article: Causes of Recurrent of Abortion

Alkhuriji¹,

Alumor²,

Haffor³

2017

ijcrr

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Abstract:Reoccurrence of Spontaneous abortion (RSA) in pregnant women is frequently encountered complications with no apparent cause. Multiple environmental and genetic factors had been studied that included; hereditary factors, hematologic and immunologic factors, endocrine factors and lifestyle factors. The key aspects of chromosomal abnormalities in RSA women were reviewed. The central theme of the hematologic and immunologic factors focused on studiesthat associated RSA to infection, clot formation, proinflammatory and anti-inflammatory cytokines as well as their genes polymorphism. The factors that underlie hormonal abnormalities and occupational hazards as they pertain to RSA were also reviewed. To conclude genes polymorphisms of inflammatory and anti-inflammatory cytokines seem promising to establish causal molecular relations with RSA.

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“…Th17 are derived in response to TGFβ and IL-6 as well as inflammation [41]. They secrete IL-17, -21, -22 [41,[81][82][83][84][85][86] cells inhibit one another and are both regulated by Treg cells. An overexpression of Th1 immunity has been thought to play a role in RPL.…”

Section: T-helper Lymphocyte-2 Cellsmentioning

confidence: 99%

“…Increased levels of Th17 cells have been found in the decidua and peripheral blood of patients with RPL compared to their controls. They have a negative impact on the early stages of pregnancy [42,76,[82][83][84][85]89].…”

Section: T-helper Lymphocyte-17 Cellsmentioning

confidence: 99%

Immunogenetic contributions to recurrent pregnancy loss

Grimstad

Krieg

2016

J Assist Reprod Genet

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While sporadic pregnancy loss is common, occurring in 15 % of pregnancies, recurrent pregnancy loss (RPL) impacts approximately 5 % of couples. Though multiple causes are known (including structural, hormonal, infectious, autoimmune, and thrombophilic causes), after evaluation, roughly half of all cases remain unexplained. The idiopathic RPL cases pose a challenging therapeutic dilemma in addition to incurring much physical and emotional morbidity. Immunogenetic causes have been postulated to contribute to these cases of RPL. Natural Killer cell, T cell expression pattern changes in the endometrium have both been shown in patients with RPL. Human leukocyte antigen (HLA) and cytokine allelic variations have also been studied as etiologies for RPL. Some of the results have been promising, however the studies are small and have not yet put forth outcomes that would change our current diagnosis and management of RPL. Larger database studies are needed with stricter control criteria before reasonable conclusions can be drawn.

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Regulation of the expression of Th17 cells and regulatory T cells by IL-27 in patients with unexplained early recurrent miscarriage

Cited by 60 publications

References 46 publications

T-Cell Abnormalities in Common Variable Immunodeficiency

T-Cell Abnormalities in Common Variable Immunodeficiency

Review Article: Causes of Recurrent of Abortion

Immunogenetic contributions to recurrent pregnancy loss

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