1997
DOI: 10.1006/cimm.1997.1181
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Regulation of the Expression of the Soluble and Membrane Forms of the Murine IL-4 Receptor

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Cited by 20 publications
(14 citation statements)
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“…Inasmuch as the membrane and soluble forms of the IL-4R are encoded by alternatively spliced messages, the potential exists for differentially regulated expression. However, a recent study by our laboratory comparing the mRNA levels for mIL-4R and sIL-4R in splenic lymphocytes exposed to a variety of stimulatory conditions, found that both types of transcripts appear to be regulated in a parallel rather than a differential manner [53].…”
Section: Discussionmentioning
confidence: 87%
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“…Inasmuch as the membrane and soluble forms of the IL-4R are encoded by alternatively spliced messages, the potential exists for differentially regulated expression. However, a recent study by our laboratory comparing the mRNA levels for mIL-4R and sIL-4R in splenic lymphocytes exposed to a variety of stimulatory conditions, found that both types of transcripts appear to be regulated in a parallel rather than a differential manner [53].…”
Section: Discussionmentioning
confidence: 87%
“…Moreover, the shift in the response of C3H mice from a Th1-to a Th2-dominated response by administration of anti-IL-12 antibodies was accompanied by an enhancement of sIL-4R production. The higher production of sIL-4R during Th2 immune responses could have resulted from a greater ability of Th2, compared with Th1 cells, to generate sIL-4R and/or the direct effects of Th2-secreted IL-4, which is known to stimulate expression of sIL-4R at both mRNA and protein levels [53]. Moreover, it could also be an indirect consequence of the relative lack of inhibitory mechanisms on sIL-4R expression promoted by Th1 cells.…”
Section: Discussionmentioning
confidence: 99%
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