Regulation of the IL-3 gene and structure and function of the IL-3 receptor

Ozu, Mariko; Koyano-Nakagawa, Naoko; Nishida, Junji; Arai, Naoko; Miyajima, Atsushi; Arai, Ken; Yokota, Takashi

doi:10.1016/s0960-5428(06)80004-5

Cited by 2 publications

(1 citation statement)

References 97 publications

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“…IL-1 induces fever, cartilage breakdown, bone resorption, thymocyte proliferation, ac tivation of T and B lymphocytes, induction of acute phase protein synthesis from hépato cytes, fibroblast proliferation and differentia tion of bone marrow stem cells [36][37][38] then respond to lineage-specific growth fac tors [39]. 1L-3 has been shown to support pro liferation and differentiation of multipotential stem cells as well as early progenitor cells of the myeloid lineage [40], The effect of IL-3 is more significant in early rather than termi nal stages of cellular maturation and is pre dominantly involved in inducible hemato poiesis [41]. However, in addition to its ac tion on myeloid lineage cells, IL-3 has been shown to promote pre-B-cell growth [42] and to induce T-cell receptor gamma gene tran scription [43] indicating the involvement of this cytokine in the growth and differentiation of the lymphoid lineage too.…”

Section: Discussionmentioning

confidence: 99%

Human Colostrum Stimulates Cytokine Production

Bessler¹,

Straussberg

Hart

et al. 1996

Neonatology

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The effect of human colostrum on the production of IL-1, IL-3 and IL-6 by peripheral blood mononuclear cells (PBMCs) has been investigated. The aqueous phase of human colostrum significantly stimulated the production of these three cytokines. These findings show the importance of breast feeding not only as a well-balanced nutrient supply but also as a source for growth-promoting factors. It is suggested that the enhanced secretion of IL-1, IL-3 and IL-6 induced by human colostrum may compensate for the lower capacity of neonatal PBMCs to produce these cytokines. It is also possible that, by stimulating the secretion of these cytokines, breast feeding may provide an additional mechanism for the regulation of the neonatal immune system and hematopoiesis.

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Section: Discussionmentioning

confidence: 99%

Human Colostrum Stimulates Cytokine Production

Bessler¹,

Straussberg

Hart

et al. 1996

Neonatology

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Interferons α/β and their receptors: place in the hierarchy of cytokines

Zav’yalov¹,

Zav’yalova²

1997

APMIS

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Interferons α/β (IFNs‐α/β) are the first cytokines to be produced by recombinant DNA technology. They regulate growth and differentiation, affecting cellular communication, signal transduction pathways and immunological control. This review focuses on the relationships between the structure and biological activities of IFNs‐α/β induced as a result of specific interactions with different types of polypeptide receptors as well as on the role of glycolipids in the modulation of these activities. The discovery of the primary structure homology of HuIFNs‐α and thymus hormone‐thymosin α‐1 (TMα1), the experimental finding of the competition between IFN‐α and TMα1 for common receptors and the reproduction by reHuIFN‐α2 of TMα1 immunomodulating activities create the basis of reHu‐IFN‐α therapeutics instead of TMα1 and potentiation of vaccines by reHuIFN‐α. The first successful attempt at grafting of the HuIFN‐α2′s TMα1‐like immunomodulating site to the designed de novo protein albeferon is described. This article also aims at reviewing recent data concerning the structure of other cytokines and their receptors. Their reciprocal structure‐function taxonomy is proposed. The place of IFNs‐α/β and their receptors in the hierarchy of cytokines is determined.

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Regulation of the IL-3 gene and structure and function of the IL-3 receptor

Cited by 2 publications

References 97 publications

Human Colostrum Stimulates Cytokine Production

Human Colostrum Stimulates Cytokine Production

Interferons α/β and their receptors: place in the hierarchy of cytokines

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