Regulation of the microvasculature during small muscle mass exercise in chronic obstructive pulmonary disease vs. chronic heart failure

Hartmann, Jacob Peter; Nymand, Stine; Munch, Gregers Winding; Ryrsø, Camilla Koch; Pedersen, Bente Klarlund; Thaning, Pia; Mortensen, Stefan P.; Berg, Ronan M. G.; Iepsen, Ulrik Winning

doi:10.3389/fphys.2022.979359

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…Exercise intolerance is a main disabling factor for many patients with chronic obstructive pulmonary disease (COPD) 1. The cause of exercise intolerance is multifactorial, and encompasses both pulmonary, cardiovascular and skeletal muscle dysfunction 2–5. Pulmonary rehabilitation (PR) is an important aspect of COPD management, with exercise training considered the most effective non-pharmacological component 1.…”

Section: Introductionmentioning

confidence: 99%

“…1 The cause of exercise intolerance is multifactorial, and encompasses both pulmonary, cardiovascular and skeletal muscle dysfunction. [2][3][4][5] Pulmonary rehabilitation (PR) is an important aspect of COPD management, with exercise training considered the most effective nonpharmacological component. 1 Evidence shows that exercise training increases exercise tolerance, reduces symptom burden and improves quality of life, while also potentially reducing mortality, when supervised.…”

Section: Introductionmentioning

confidence: 99%

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Fidelity and tolerability of two high-intensity interval training protocols in patients with COPD: a randomised cross-over pilot study

Nymand

Hartmann

Rasmussen

et al. 2023

BMJ Open Sport Exerc Med

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ObjectivesHigh-intensity interval training (HIIT) during pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) may alleviate the symptom burden, but the fidelity and tolerability of HIIT using long or short intervals in patients with COPD are unknown.MethodsTwelve patients with moderate-to-severe COPD were included in a randomised cross-over pilot study. They completed two supervised HIIT protocols (4×4 and 10×1). To compare the two HIIT protocols, completed training amount, exercise intensity and perceived tolerability (assessed by a 10-point Likert scale) were integrated in a red–amber–green rating system. If a training session received a red ranking, it was considered unacceptable, if it received an amber ranking it was applicable with precautions, and if it received a green ranking it was considered feasible.ResultsAll patients completed the total training amount in both protocols. The 4×4 protocol resulted in three amber training sessions due to low perceived tolerability. The 10×1 protocol resulted in two red training sessions due to intensity reductions, and two amber training sessions because of low perceived tolerability. There was no statistical difference in perceived tolerability or time spent with an HR ≥85% of HRmax.ConclusionsHIIT using longer intervals (4×4) at a relatively lower intensity resulted in higher fidelity expressed by fewer adjustments to the protocol, whereas there was no difference between protocols in perceived tolerance. The 4×4 protocol seems to have a higher fidelity compared with the 10×1 protocol in patients with moderate-to-severe COPD.Trial registration numberNCT05273684.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fidelity and tolerability of two high-intensity interval training protocols in patients with COPD: a randomised cross-over pilot study

Nymand

Hartmann

Rasmussen

et al. 2023

BMJ Open Sport Exerc Med

Self Cite

View full text Add to dashboard Cite

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The recent development, application, and future prospects of muscle atrophy animal models

Zhang,

Hu,

Huang

et al. 2024

MedComm – Future Medicine

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Muscle atrophy, characterized by the loss of muscle mass and function, is a hallmark of sarcopenia and cachexia, frequently associated with aging, malignant tumors, chronic heart failure, and malnutrition. Moreover, it poses significant challenges to human health, leading to increased frailty, reduced quality of life, and heightened mortality risks. Despite extensive research on sarcopenia and cachexia, consensus in their assessment remains elusive, with inconsistent conclusions regarding their molecular mechanisms. Muscle atrophy models are crucial tools for advancing research in this field. Currently, animal models of muscle atrophy used for clinical and basic scientific studies are induced through various methods, including aging, genetic editing, nutritional modification, exercise, chronic wasting diseases, and drug administration. Muscle atrophy models also include in vitro and small organism models. Despite their value, each of these models has certain limitations. This review focuses on the limitations and diverse applications of muscle atrophy models to understand sarcopenia and cachexia, and encourage their rational use in future research, therefore deepening the understanding of underlying pathophysiological mechanisms, and ultimately advancing the exploration of therapeutic strategies for sarcopenia and cachexia.

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Within‐session repeatability of Doppler ultrasound leg blood flow assessments during exercise in patients with chronic obstructive pulmonary disease

Mohammad,

Hartmann

2024

Clin Physio Funct Imaging

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Doppler ultrasound can be used to evaluate leg blood flow (Q̇leg), especially of interest when investigating peripheral vascular limitations in patients with chronic obstructive pulmonary disease (COPD). However, the within‐session repeatability, a subdomain of test‐retest reliability, of this method remains unknown. This study aimed to provide within‐session repeatability estimates of Doppler ultrasound‐based Q̇leg at rest and during single‐leg knee‐extensor exercise (KEE) in patients with COPD, and to compare these estimates to matched healthy controls. In this case‐controlled study, 16 participants with COPD were matched based on sex and age with 16 healthy controls. All participants underwent measurement of Q̇leg using Doppler ultrasound in a KEE setup at various intensities with the same measurement being performed again separated by 10 s. Smallest real difference (SRD) was lowest at rest in both groups and increased during exercise, reaching values ranging from 164 to 231 mL in COPD and 122–180 mL in the control group. The coefficient of variance (CV) was highest at rest and decreased during exercise to values ranging from 4.0% to 5.0% in COPD and 2.6%–3.2% in the control group. The CV was significantly lower in the control group during 0 watt and exercise at 20% of max watt, but apart from that, no reliability estimates were different between groups. To conclude, Doppler ultrasound showed nearly equal within‐session repeatability when evaluating Q̇leg in COPD patients and healthy individuals with a CV not exceeding 5% during exercise for both groups.

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Regulation of the microvasculature during small muscle mass exercise in chronic obstructive pulmonary disease vs. chronic heart failure

Cited by 5 publications

References 53 publications

Fidelity and tolerability of two high-intensity interval training protocols in patients with COPD: a randomised cross-over pilot study

Fidelity and tolerability of two high-intensity interval training protocols in patients with COPD: a randomised cross-over pilot study

The recent development, application, and future prospects of muscle atrophy animal models

Within‐session repeatability of Doppler ultrasound leg blood flow assessments during exercise in patients with chronic obstructive pulmonary disease

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