Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents

Leg ulcer induced by hydroxycarbamide in sickle cell disease: What is the therapeutic impact?

“…HC leads to an increase in the synthesis of haemoglobin F in the precursor erythroids, with a protective effect . It now seems that its effectiveness is actually based on multiple mechanisms with a systemic effect: reduction of leukocyte adhesion to the endothelium, reduction of leukocytosis and thrombocytosis that are often associated, increase of the deformability of red blood cells under treatment, and it may have an impact on the metabolism of NO . HC has thus become the standard background treatment for certain phenotypes (SS and Sβ° in particular).…”

“…It is now established that its impact is not restricted to the elements of the erythrocyte lineage and its efficacy relies on multiple mechanisms: induction of foetal haemoglobin synthesis and increase of the deformability of the red blood cells under treatment . but also reduction of leukocyte adhesion to the endothelium, reduction of associated leukocytosis and thrombocytosis, and, finally, affecting the metabolism of nitric oxide . HC has thus become the standard long‐term treatment for certain phenotypes (SS and Sβ° in particular).…”

Synthesis and biological activity of hydrazones of o- and p-hydroxybenzoic acids. Spatial structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide

“…The interest to hydrazones has recently emerged [1,2] due to a broad range of their biological activity: antidepressant, antiinflammatory, antimalarial, antimicrobial, antiviral, and antitumor [3,4]. For example, ftivazide, saluzide, and related drugs are used in the tuberculosis treatment [5,6]. Inhibitors of many enzymes like cyclooxygenase, monoaminoxidase, epoxide hydrolase, and various cathepsins have been prepared based on hydrazones [7][8][9][10][11].…”

“…Yield 1.21 g (90%), mp 220°С (EtOH). 1 Н NMR spectrum, δ, ppm: 3.76 s (3Н, ОСН 3 ), 6.83 d (2Н, СН 15,17 Ar , 3 J НН = 8.7 Hz), 6.97 d (2Н, СН 2,6 Ar , 3 J НН = 8.7 Hz), 7.61 d (2Н, СН 14,18 Ar , 3 J НН = 8.7 Hz), 7.77 d (2Н, СН 3,5 Ar , 3 J НН = 7.8 Hz), 8.34 s (1Н, N=СН), 10.03 s (1Н, ОН), 11.46 s (1Н, NН). 13…”

Melatonin: new insights on its therapeutic properties in diabetic complications

“…The anti-oxidative effects of melatonin is attributed to its direct free radical scavenging properties as well as inducing the production of other anti-oxidant enzymes including glutathione peroxidase (GPx), glutathione reductase (GR), catalase (CAT) and superoxide dismutase (SOD) [27][28][29][30]. Melatonin also inhibits the expression of pro-oxidant enzymes such as nitric oxide (NO) synthase (NOS), cyclooxygenase-2 (COX-2), myeloperoxidase and eosinophil peroxidase [31,32]. Free radicals such as ROS are waste products of cellular metabolism.…”