Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity

Johansen, Finn–Eirik; Kaetzel, Charlotte S.

doi:10.1038/mi.2011.37

Cited by 288 publications

(269 citation statements)

References 25 publications

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“…2). Although the results of IL4 treatment are consistent with previous findings in intestinal epithelial cells (23,24,28), importantly, IL13 treatment has a similar or greater effect on pIgR expression, which has not been demonstrated previously. Together, these results indicate that STAT6 regulates the expression of pIgR in renal epithelial cells and that pIgR expression is increased in cyst-lining cells.…”

Section: Pigr Is Expressed In Renal Cyst-lining Cells and Processedsupporting

confidence: 82%

Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease

Olsan

Matsushita

Rezaei

et al. 2015

Journal of Biological Chemistry

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Section: Pigr Is Expressed In Renal Cyst-lining Cells and Processedsupporting

confidence: 82%

Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease

Olsan

Matsushita

Rezaei

et al. 2015

Journal of Biological Chemistry

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“…Immunological benefits of breast milk include prevention of infection, protection against inflammation, and promotion of intestinal barrier function (5). After weaning, IgA produced by plasma cells in the intestinal lamina propria is transported across ECs into the gut lumen by pIgR (6). There is a major gap in our knowledge of whether the beneficial effects of breast milk-derived SIgA persist after weaning.…”

mentioning

confidence: 95%

Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression

Rogier

Frantz

Bruno

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

388

332

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Significance An experimental system was developed in mice to study the long-term benefits of early exposure to secretory antibodies of the IgA class (SIgA) in breast milk. We found that breast milk-derived SIgA promoted intestinal epithelial barrier function in suckling neonates, preventing systemic infection by potential pathogens. Long-term benefits of early exposure to SIgA included maintenance of a healthy gut microbiota and regulation of gene expression in intestinal epithelial cells. These findings suggest that maternal antibodies provide benefits to the intestinal immune system of the breast-fed infant, which persist into adulthood.

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“…This effect is probably due to the induction of high IgG titers in sera, which lead to the transudation and/or FcRn transport to mucosal surfaces (26). The specific IgA responses at mucosal surfaces might be due to an efficient stimulation of B cells in mucosal tissues or transport of blood IgA by the polymeric IgR (27).…”

Section: Nod2/tlr2 Chimeric Ligand Enhances Systemic and Mucosal Immumentioning

confidence: 99%

Cutting Edge: New Chimeric NOD2/TLR2 Adjuvant Drastically Increases Vaccine Immunogenicity

Pavot

Rochereau

Rességuier

et al. 2014

The Journal of Immunology

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TLR ligands are critical activators of innate immunity and are being developed as vaccine adjuvants. However, their usefulness in conjunction with NOD-like receptor agonists remains poorly studied. In this study, we evaluated a new ligand that targets both TLR2 and NOD2 receptors. We assessed its ability to enhance dendritic cell maturation in vitro in addition to improving systemic and mucosal immune responses in mice. The chimeric NOD2/TLR2 ligand induced synergistic upregulation of dendritic cell maturation markers, costimulatory molecules, and secretion of proinflammatory cytokines compared with combinations of separate ligands. Furthermore, when coadministered with biodegradable nanoparticles carrying a model Ag, the ligand was able to induce high Ag-specific IgA and IgG titers at both systemic and mucosal sites after parenteral immunizations. These findings point out the potential utility of chimeric molecules TLR/NOD as adjuvants for vaccines to induce systemic and mucosal immune responses.

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Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity

Cited by 288 publications

References 25 publications

Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease

Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease

Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression

Cutting Edge: New Chimeric NOD2/TLR2 Adjuvant Drastically Increases Vaccine Immunogenicity

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