Regulation of the starfish sperm acrosome reaction by cGMP, pH, cAMP and Ca2+

Matsumoto, Midori; Kawase, Osamu; Islam, M. Sadiqul; Naruse, Masahiro; Watanabe, Shin Nosuke; Ishikawa, Rei; Hoshi, Motonori

doi:10.1387/ijdb.072511mm

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…Besides ROS, the sperm adenylyl cyclase could also be stimulated by other factors, such as calcium or HCO 3 − (Carlson et al. 2007), by the dilution of the epididymal factors inhibiting adenylyl cyclase (Aitken 2000), by cytoplasmic alkalization (Matsumoto et al. 2008) or by their combination.…”

Section: Male Reproductive Systemmentioning

confidence: 99%

“…The methods used as well as the impact of leucocyte contamination must always be considered. Besides ROS, the sperm adenylyl cyclase could also be stimulated by other factors, such as calcium or HCO 3 ) (Carlson et al 2007), by the dilution of the epididymal factors inhibiting adenylyl cyclase (Aitken 2000), by cytoplasmic alkalization (Matsumoto et al 2008) or by their combination. The presence of one activated leucocyte per 20 000 sperm cells can produce a detectable amount of ROS (Ford 2004).…”

Section: Male Reproductive Systemmentioning

confidence: 99%

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Reactive oxygen and nitrogen species in normal physiological processes

et al. 2009

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Reactive oxygen species (ROS) and reactive nitrogen species have generally been considered as being highly reactive and cytotoxic molecules. Besides their noxious effects, ROS participate in physiological processes in a carefully regulated manner. By way of example, microbicidal ROS are produced in professional phagocytes, ROS function as short-lived messengers having a role in signal transduction and, among other processes, participate in the synthesis of the iodothyronine hormones, reproduction, apoptosis and necrosis. Because of their ability to mediate a crosstalk between key molecules, their role might be dual (at least in some cases). The levels of ROS increase from a certain age, being associated with various diseases typical of senescence. The aim of this review is to summarize the recent findings on the physiological role of ROS. Other issues addressed are an increase in ROS levels during ageing, and the possibility of the physiological nature of this process.

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Section: Male Reproductive Systemmentioning

confidence: 99%

Section: Male Reproductive Systemmentioning

confidence: 99%

Reactive oxygen and nitrogen species in normal physiological processes

et al. 2009

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“…It transiently increases the intracellular pH and calcium via the activation of asterosap receptor that is a guanylyl cyclase located in the sperm flagellar plasma membrane [159,160,161]. Calcium and pH increase are essential to trigger acrosome reaction.…”

Section: The Glycobiology In Fertilizationmentioning

confidence: 99%

Glycobiology of Reproductive Processes in Marine Animals: The State of the Art

Gallo

Costantini

2012

Marine Drugs

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Glycobiology is the study of complex carbohydrates in biological systems and represents a developing field of science that has made huge advances in the last half century. In fact, it combines all branches of biomedical research, revealing the vast and diverse forms of carbohydrate structures that exist in nature. Advances in structure determination have enabled scientists to study the function of complex carbohydrates in more depth and to determine the role that they play in a wide range of biological processes. Glycobiology research in marine systems has primarily focused on reproduction, in particular for what concern the chemical communication between the gametes. The current status of marine glycobiology is primarily descriptive, devoted to characterizing marine glycoconjugates with potential biomedical and biotechnological applications. In this review, we describe the current status of the glycobiology in the reproductive processes from gametogenesis to fertilization and embryo development of marine animals.

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“…For example, in sea urchin and starfish, asterosap works as a chemotactic agent and acts on a receptor associated with guanylyl cyclase located in the sperm flagellar plasma membrane and thereby stimulates the motility of the sperm. This is achieved through the rapid intracellular synthesis of cGMP (the level increases up to 60-fold within 100-200 ms), the increase of pH, and the transient elevation of Ca 2+ caused by a Na + /Ca 2+ exchanger [11,12].…”

Section: Mutual Activation Of Sperm and Egg At Fertilizationmentioning

confidence: 99%

Actin, more than just a housekeeping protein at the scene of fertilization

Santella

Chun

2011

Sci. China Life Sci.

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Since the first demonstration of sperm entry into the fertilized eggs of Mediterranean sea urchin Paracentrotus lividus by Hertwig (1876), enormous progress and insights have been made on this topic. However, the precise molecular mechanisms underlying fertilization are largely unknown. The two most dramatic changes taking place in the zygote immediately after fertilization are: (i) a sharp increase of intracellular Ca 2+ that initiates at the sperm interaction site and traverses the egg cytoplasm as a wave, and (ii) the concomitant dynamic rearrangement of the actin cytoskeleton. Traditionally, this has been studied most extensively in the sea urchin eggs, but another echinoderm, starfish, whose eggs are much bigger and transparent, has facilitated experimental approaches using microinjection and fluorescent imaging methodologies. Thus in starfish, it has been shown that the sperm-induced Ca 2+ increase in the fertilized egg can be recapitulated by several Ca 2+ -evoking second messengers, namely inositol 1,4,5-trisphosphate (InsP 3 ), cyclic ADP-ribose (cADPr) and nicotinic acid adenine dinucleotide phosphate (NAADP), which may play distinct roles in the generation and propagation of the Ca 2+ waves. Interestingly, it has also been found that the dynamic rearrangement of the actin cytoskeleton in the fertilized eggs plays pivotal roles in guiding monospermic sperm entry and in the fine modulation of the intracellular Ca 2+ signaling. As it is well known that Ca 2+ regulates the structure of the actin cytoskeleton, our finding that Ca 2+ signaling can be reciprocally affected by the state of the actin cytoskeleton raises an intriguing possibility that actin and Ca 2+ signaling may form a 'positive feedback loop' that accelerates the downstream events of fertilization. Perturbation of the cortical actin networks also inhibits cortical granules exocytosis. Polymerizing actin bundles also compose the 'acrosome process,' a tubular structure protruding from the head of fertilizing sperm. Hence, actin, which is one of the most strictly conserved proteins in eukaryotes, modulates almost all major aspects of fertilization. starfish, calcium, egg maturation, fertilization, PIP2, actin cytoskeleton, cofilin Citation:Santella L, Chun J T. Actin, more than just a housekeeping protein at the scene of fertilization.

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Regulation of the starfish sperm acrosome reaction by cGMP, pH, cAMP and Ca2+

Cited by 12 publications

References 24 publications

Reactive oxygen and nitrogen species in normal physiological processes

Reactive oxygen and nitrogen species in normal physiological processes

Glycobiology of Reproductive Processes in Marine Animals: The State of the Art

Actin, more than just a housekeeping protein at the scene of fertilization

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