Regulation of the tumor immune microenvironment by cancer-derived circular RNAs

Guan, Liping; QIAN, H; Shi, Fenfen; Gao, Bo; Wang, Mengxin; Zhou, Xiang; Han, Tao; Ren, Wenjie

doi:10.1038/s41419-023-05647-w

Cited by 19 publications

(8 citation statements)

References 121 publications

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“…Previous studies have revealed that circRNAs can interact with the tumor immune microenvironment by participating in multiple approaches ( 19 ). In addition to participating in M2 polarization and interacting with macrophages, circRNAs mediate tumor immune surveillance ( 135 , 136 ), regulate immune escape via PD-L1 ( 137 – 140 ), regulate natural killer cells’ cytotoxicity ( 141 – 143 ), and regulate neutrophils, myeloid-derived suppressor cells, and cancer-associated fibroblast ( 144 ). However, whether circRNA affects ESCC TME through the aforementioned effects, except M2 polarization, has not yet been reported.…”

Section: Circrnas As a Novel Regulator Of Tumor Microenvironment In Esccmentioning

confidence: 99%

Roles of circRNA dysregulation in esophageal squamous cell carcinoma tumor microenvironment

Yao

Cai

et al. 2023

Front. Oncol.

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Esophageal squamous cell carcinoma (ESCC) is the most prevalent histological esophageal cancer characterized by advanced diagnosis, metastasis, resistance to treatment, and frequent recurrence. In recent years, numerous human disorders such as ESCC, have been linked to abnormal expression of circular RNAs (circRNAs), suggesting that they are fundamental to the intricate system of gene regulation that governs ESCC formation. The tumor microenvironment (TME), referring to the area surrounding the tumor cells, is composed of multiple components, including stromal cells, immune cells, the vascular system, extracellular matrix (ECM), and numerous signaling molecules. In this review, we briefly described the biological purposes and mechanisms of aberrant circRNA expression in the TME of ESCC, including the immune microenvironment, angiogenesis, epithelial-to-mesenchymal transition, hypoxia, metabolism, and radiotherapy resistance. As in-depth research into the processes of circRNAs in the TME of ESCC continues, circRNAs are promising therapeutic targets or delivery systems for cancer therapy and diagnostic and prognostic indicators for ESCC.

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Section: Circrnas As a Novel Regulator Of Tumor Microenvironment In Esccmentioning

confidence: 99%

Roles of circRNA dysregulation in esophageal squamous cell carcinoma tumor microenvironment

Yao

Cai

et al. 2023

Front. Oncol.

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“… 29 These factors can impede the efficacy of immunotherapy. 15 30 Dysregulation of circRNAs promotes immune destruction evasion and reduced immunotherapy efficacy. CircRNAs employ diverse regulatory mechanisms—from sponging miRNAs and proteins to scaffolding proteins and translating peptides.…”

Section: Introductionmentioning

confidence: 99%

TCCIA: a comprehensive resource for exploring CircRNA in cancer immunotherapy

Wang,

Xiong,

Zhang

et al. 2024

J Immunother Cancer

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BackgroundImmunotherapies targeting immune checkpoints have gained increasing attention in cancer treatment, emphasizing the need for predictive biomarkers. Circular RNAs (circRNAs) have emerged as critical regulators of tumor immunity, particularly in the PD-1/PD-L1 pathway, and have shown potential in predicting immunotherapy efficacy. Yet, the detailed roles of circRNAs in cancer immunotherapy are not fully understood. While existing databases focus on either circRNA profiles or immunotherapy cohorts, there is currently no platform that enables the exploration of the intricate interplay between circRNAs and anti-tumor immunotherapy. A comprehensive resource combining circRNA profiles, immunotherapy responses, and clinical outcomes is essential to advance our understanding of circRNA-mediated tumor-immune interactions and to develop effective biomarkers.MethodsTo address these gaps, we constructed The Cancer CircRNA Immunome Atlas (TCCIA), the first database that combines circRNA profiles, immunotherapy response data, and clinical outcomes across multicancer types. The construction of TCCIA involved applying standardized preprocessing to the raw sequencing FASTQ files, characterizing circRNA profiles using an ensemble approach based on four established circRNA detection tools, analyzing tumor immunophenotypes, and compiling immunotherapy response data from diverse cohorts treated with immune checkpoint blockades (ICBs).ResultsTCCIA encompasses over 4,000 clinical samples obtained from 25 cohorts treated with ICBs along with other treatment modalities. The database provides researchers and clinicians with a cloud-based platform that enables interactive exploration of circRNA data in the context of ICB. The platform offers a range of analytical tools, including browse of identified circRNAs, visualization of circRNA abundance and correlation, association analysis between circRNAs and clinical variables, assessment of the tumor immune microenvironment, exploration of tumor molecular signatures, evaluation of treatment response or prognosis, and identification of altered circRNAs in immunotherapy-sensitive and resistant tumors. To illustrate the utility of TCCIA, we showcase two examples, including circTMTC3 and circMGA, by employing analysis of large-scale melanoma and bladder cancer cohorts, which unveil distinct impacts and clinical implications of different circRNA expression in cancer immunotherapy.ConclusionsTCCIA represents a significant advancement over existing resources, providing a comprehensive platform to investigate the role of circRNAs in immuno-oncology.

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“…Recent research elucidates the involvement of PHD finger proteins in the immune response to cancer therapy, shedding light on their impact on treatment effectiveness. For example, interactions between circular RNAs and PHD proteins influence immune responses, impacting the efficacy of immunotherapy ( Guan et al, 2023 ). Although PHD finger proteins are a recent addition to cancer immunotherapy, their capacity to impact cancer development and shape the immune system’s response to treatment warrants further exploration and consideration.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the dual roles of PHD finger proteins from oncogenic drivers to tumor suppressors

Fan,

Jiang,

Zhou

et al. 2024

Front. Cell Dev. Biol.

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PHD (plant homeodomain) finger proteins emerge as central epigenetic readers and modulators in cancer biology, orchestrating a broad spectrum of cellular processes pivotal to oncogenesis and tumor suppression. This review delineates the dualistic roles of PHD fingers in cancer, highlighting their involvement in chromatin remodeling, gene expression regulation, and interactions with cellular signaling networks. PHD fingers’ ability to interpret specific histone modifications underscores their influence on gene expression patterns, impacting crucial cancer-related processes such as cell proliferation, DNA repair, and apoptosis. The review delves into the oncogenic potential of certain PHD finger proteins, exemplified by PHF1 and PHF8, which promote tumor progression through epigenetic dysregulation and modulation of signaling pathways like Wnt and TGFβ. Conversely, it discusses the tumor-suppressive functions of PHD finger proteins, such as PHF2 and members of the ING family, which uphold genomic stability and inhibit tumor growth through their interactions with chromatin and transcriptional regulators. Additionally, the review explores the therapeutic potential of targeting PHD finger proteins in cancer treatment, considering their pivotal roles in regulating cancer stem cells and influencing the immune response to cancer therapy. Through a comprehensive synthesis of current insights, this review underscores the complex but promising landscape of PHD finger proteins in cancer biology, advocating for further research to unlock novel therapeutic avenues that leverage their unique cellular roles.

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Regulation of the tumor immune microenvironment by cancer-derived circular RNAs

Cited by 19 publications

References 121 publications

Roles of circRNA dysregulation in esophageal squamous cell carcinoma tumor microenvironment

Roles of circRNA dysregulation in esophageal squamous cell carcinoma tumor microenvironment

TCCIA: a comprehensive resource for exploring CircRNA in cancer immunotherapy

Deciphering the dual roles of PHD finger proteins from oncogenic drivers to tumor suppressors

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