Regulation of Tight Junction by Cadherin Adhesion and Its Implication in Inflammation and Cancer

Nasir Uddin, S. M.; Sultana, Asfia; Fatima, Asma; Geethakumari, Anupriya M.; Biswas, Kabir H.

doi:10.1007/978-981-99-2415-8_2

Tight Junctions in Inflammation and Cancer 2023

DOI: 10.1007/978-981-99-2415-8_2

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Regulation of Tight Junction by Cadherin Adhesion and Its Implication in Inflammation and Cancer

S. M. Nasir Uddin,

Asfia Sultana,

Asma Fatima

et al.

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2024

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Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease

Azizi,

Otani,

Mykuliak

et al. 2024

Human Molecular Genetics

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Variants of talin-1 (TLN1) have recently been linked with spontaneous coronary artery dissection (SCAD) a condition where a tear can form in the wall of a heart artery necessitating immediate medical care. One talin-1 variant, A2013T, has an extensive familial pedigree of SCAD, which led to the screening for, and identification of, further talin-1 variants in SCAD patients. Here we evaluated these variants with commonly used pathogenicity prediction tools and found it challenging to reliably classify SCAD-associated variants, even A2013T where the evidence of a causal role is strong. Using biochemical and cell biological methods, we show that SCAD-associated variants in talin-1, which would typically be classified as non-pathogenic, still cause a measurable impact on protein structure and cell behaviour, including cell movement and wound healing capacity. Together, this indicates that even subtle variants in central mechanosensitive adapter proteins, can give rise to significant health impacts at the individual level, suggesting the need for a possible re-evaluation of the scoring criteria for pathogenicity prediction for talin variants.

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Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease

Azizi,

Otani,

Mykuliak

et al. 2024

Human Molecular Genetics

View full text Add to dashboard Cite

show abstract

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Regulation of Tight Junction by Cadherin Adhesion and Its Implication in Inflammation and Cancer

Cited by 1 publication

References 83 publications

Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease

Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease

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