2016
DOI: 10.7554/elife.14116
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Regulation of two motor patterns enables the gradual adjustment of locomotion strategy in Caenorhabditis elegans

Abstract: In animal locomotion a tradeoff exists between stereotypy and flexibility: fast long-distance travelling (LDT) requires coherent regular motions, while local sampling and area-restricted search (ARS) rely on flexible movements. We report here on a posture control system in C. elegans that coordinates these needs. Using quantitative posture analysis we explain worm locomotion as a composite of two modes: regular undulations versus flexible turning. Graded reciprocal regulation of both modes allows animals to fl… Show more

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Cited by 64 publications
(121 citation statements)
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“…It is released by a forward-promoting premotor interneuron (AVB) and other neurons, and may act through multiple and upper layer interneurons (Flavell et al, 2013). A NLP-12-releasing interneuron (DVA) coordinates with a FLP-1-releasing interneuron (AVK) to facilitate a body posture change that is associated with halting the forward runs when animals encounter an oxygen reduction (Hums et al, 2016). Our results add another layer to motor circuit modulation - a descending input to the motor circuit from a FLP-14-releasing neuron RID.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is released by a forward-promoting premotor interneuron (AVB) and other neurons, and may act through multiple and upper layer interneurons (Flavell et al, 2013). A NLP-12-releasing interneuron (DVA) coordinates with a FLP-1-releasing interneuron (AVK) to facilitate a body posture change that is associated with halting the forward runs when animals encounter an oxygen reduction (Hums et al, 2016). Our results add another layer to motor circuit modulation - a descending input to the motor circuit from a FLP-14-releasing neuron RID.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to biogenic amine neuromodulators, its genome contains 113 genes that may encode up to 250 distinct peptides of three classes (Li and Kim, 2010): the insulin-like (INS) (Pierce et al, 2001), FMRF-amide-related (FLP), and non-insulin/non-FMRF-amide-related (NLP) (Husson et al, 2007). A number of these neuropeptides already have assigned roles, affecting ‘simple’ (locomotion, feeding, egg-laying) to ‘complex’ (mating, lethargus, aggregation, learning) behaviors (Beets et al, 2012; Bendena et al, 2008; Bhattacharya et al, 2014; Chalasani et al, 2007; Chen et al, 2013; de Bono and Bargmann, 1998; Garrison et al, 2012; Hums et al, 2016; Janssen et al, 2009; Macosko et al, 2009; Turek et al, 2016; Waggoner et al, 2000; others). For instance, the NLP-type PDF-1 increases velocity and suppresses reversals through premotor and other interneurons (Flavell et al, 2013; Meelkop et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…Layers are densely connected. We fit all NN architectures for each individual extrinsic feature input (blocks 1-4), but also consider combinations of extrinsic feature inputs (blocks [5][6]. For comparison, we include GLMs described in 5D of the main text (indicated with "linear" in blocks 1-4).…”
Section: Figure S11mentioning
confidence: 99%
“…Prior work has shown that C. elegans NLP-12 neuropeptides are key modulatory signals in the control of behavioral adaptations to changing environmental conditions, such as food availability or oxygen abundance. [6][7][8] The NLP-12 system is the closest relative of the mammalian Cholecystokinin (CCK) neuropeptide system and is highly conserved across flies, worms and mammals. [9][10][11] CCK is abundantly expressed in the mammalian brain, however a clear understanding of the regulatory actions of CCK on the circuits where it is expressed is only now beginning to emerge.…”
Section: Introductionmentioning
confidence: 99%