Regulation of type I and type III interferon induction in response to pathogen sensing

Gewaid, Hossam; Bowie, Andrew G

doi:10.1016/j.coi.2024.102424

Current Opinion in Immunology

2024

DOI: 10.1016/j.coi.2024.102424

|View full text |Cite

Regulation of type I and type III interferon induction in response to pathogen sensing

Hossam Gewaid,

Andrew G Bowie

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Nuclear factor kappa-B cell (NF-κB), interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection

Savitz,

McKinney,

Meier

et al. 2025

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

Nuclear factor kappa-B cell (NF-κB), interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection

Savitz,

McKinney,

Meier

et al. 2025

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

A new antibacterial with anti-inflammatory properties promotes wound healing through inhibiting cGAS/STING/NF-κB/IRF3 pathway

Yao,

Xiang,

Yang

et al. 2024

International Immunopharmacology

View full text Add to dashboard Cite

An NF‐κB‐regulated cytokine enhances the antiviral resistance of silkworm, Bombyx mori

Wei,

Liu,

et al. 2024

Insect Molecular Biology

View full text Add to dashboard Cite

Insect NF‐κB‐like factor, Relish, is activated by viral infection and induces the production of antiviral proteins. In this study, we performed a transcriptomic analysis of BmE cells expressing the active form of BmRelish (BmRelishact) and identified BmVago‐like as the most strongly‐induced secreted‐protein. Expression of BmVago‐like was specifically triggered by Bombyx mori Nucleo Polyhedro Virus (BmNPV) infection and regulated by BmSTING‐BmRelish pathway. Incubating the fresh culture of cells with supernatant medium of BmVago‐like expressing cells or recombinant BmVago‐like protein (rBmVago‐like) significantly increased antiviral resistance. On the contrary, reducing the expression of Bmvago‐like by RNA interference (RNAi) in BmE cells as well as in silkworm larvae impaired antiviral response. Furthermore, we constructed transgenic silkworm line over‐expressing BmVago‐like (BmVago‐likeOV) and found they had markedly lower viral load and higher survival rate after BmNPV infection compared with the wild‐type control. Co‐immunoprecipitation assay showed Bmintegrin β1 interacts with BmVago‐like and it was involved in BmVago‐like mediated antiviral response. Finally, we found the expression level of signalling molecules in the JAK–STAT pathway increased in rBmVago‐like‐treated cells and BmVago‐likeOV silkworm larvae but decreased in RNAi‐treated cells. In summary, our research uncovered an inducible antiviral response in silkworm mediated by cytokine BmVago‐like, which is the downstream effector of BmSTING‐BmRelish pathway and functions as an antiviral cytokine.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Regulation of type I and type III interferon induction in response to pathogen sensing

Cited by 4 publications

References 58 publications

Nuclear factor kappa-B cell (NF-κB), interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection

Nuclear factor kappa-B cell (NF-κB), interferon regulatory Factor, and glucocorticoid receptor pathway activation in major depressive Disorder: The role of cytomegalovirus infection

A new antibacterial with anti-inflammatory properties promotes wound healing through inhibiting cGAS/STING/NF-κB/IRF3 pathway

An NF‐κB‐regulated cytokine enhances the antiviral resistance of silkworm, Bombyx mori

Contact Info

Product

Resources

About