Regulation of ventilation during exercise at 10,200 ft in athletes born at low altitude

Reeves, J. T.; Grover, R. F.; Cohn, Jerome E.

doi:10.1152/jappl.1967.22.3.546

Cited by 33 publications

(26 citation statements)

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“…The similarity of V E BTPS as percent of VO 2 max (Fig. 3B) during incremental treadmill exercise at different pressures has been reported for residents at 1,000 ft (734 mmHg) taken acutely (40 h) to 10,200 ft (530 mmHg) and for residents at 10,200 ft taken acutely to 1,000 ft (13,29). It was suggested that V E BTPS " : : : is regulated by some mechanism which senses a given effort in terms of exercise capacity.…”

Section: Discussionsupporting

confidence: 73%

“…Maher et al (22) reported a 32% reduction on day 2 which returned minimally after remaining 10 days at 458 mmHg. Average data from Dill et al (9) showed a 15% decrease at 455 mmHg in four subjects after less than 1 h. Reeves et al (29) reported an insignificant drop in five young males on the second day after ascent from 734 to 530 mmHg, suggesting that the altitude may have been too low to induce sufficient hypocapnia because the PaO 2 measured in two subjects was near 60 mmHg, the threshold of hypoxemia required for V E to respond (28). The range in values of V E STPD attenuation in these reports indicates that it depends on the magnitude of the (11) pressure change, the length of the time and the rate of the pressure drop before measurements are made, the subjects' hypoxic chemosensitivity, and the intensity of the exercise where measurements are made.…”

Section: Discussionmentioning

confidence: 94%

“…Observations after acute exposures have been reported by Stenberg et al (31) and Elliott et al (10); their data show that in spite of the early increase of V E BTPS at 462 and 406 mmHg, respectively, the V E STPD/VO 2 ratio was lower than at sea level during steady-state submaximal workloads and at VO 2 max by ≈20%. Other reports contain serial measurements after 1-3 days and later after acclimatization (9,14,22,29). Lower resting V E STPD during the first day at altitude compared with pre-ascent and subsequent measurements 3-4 days later have also been reported, suggesting early transient hypoxic ventilatory depression and progressive hypocapnia (16).…”

Section: Introductionmentioning

confidence: 99%

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V_ESTPD as a measure of ventilatory acclimatization to hypobaric hypoxia

Loeppky

Sheard

Salgado

et al. 2016

Physiology International

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This study compared the ventilation response to an incremental ergometer exercise at two altitudes: 633 mmHg (resident altitude = 1,600 m) and following acute decompression to 455 mmHg (≈4,350 m altitude) in eight male cyclists and runners. At 455 mmHg, the V E STPD at RER <1.0 was significantly lower and the V E BTPS was higher because of higher breathing frequency; at VO 2 max, both V E STPD and V E BTPS were not significantly different. As percent of VO 2 max, the V E BTPS was nearly identical and V E STPD was 30% lower throughout the exercise at 455 mmHg. The lower V E STPD at lower pressure differs from two classical studies of acclimatized subjects (Silver Hut and OEII), where V E STPD at submaximal workloads was maintained or increased above that at sea level. The lower V E STPD at 455 mmHg in unacclimatized subjects at submaximal workloads results from acute respiratory alkalosis due to the initial fall in HbO 2 (≈0.17 pHa units), reduction in PACO 2 (≈5 mmHg) and higher PAO 2 throughout the exercise, which are partially pre-established during acclimatization. Regression equations from these studies predict V E STPD from VO 2 and P B in unacclimatized and acclimatized subjects. The attainment of ventilatory acclimatization to altitude can be estimated from the measured vs. predicted difference in V E STPD at low workloads after arrival at altitude.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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V_ESTPD as a measure of ventilatory acclimatization to hypobaric hypoxia

Loeppky

Sheard

Salgado

et al. 2016

Physiology International

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“…v o 2 was reduced an average of 25% on the day afte r arrival. Periodic testin g over the following 17 days indicated no change in m axim um VO, (Reeves, Grover and Cohn [ 1966]), i.e. there was no m easurable im provem ent in the cap acity for oxygen u p tak e w ith con tin u ed residence a t th e higher a ltitu d e ( fig.…”

Section: Resultsmentioning

confidence: 96%

Exercise Performance of Athletes at Sea Level and 3100 Meters Altitude

Grover¹,

Reeves²,

Grover³

et al. 1966

Respiration

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“…Physiological variables that contribute to the increase in submaximal endurance capacity with altitude acclimatization include an increase in exercise minute ventilation (VE) (21,77) and decrease in plasma volume (PV) (39,96,101,113). These changes cause respective increases in arterial oxygen saturation (Sa0 2 ) and hemoglobin concentration ([Hb]).…”

Section: Introductionmentioning

confidence: 99%