Regulation of vitamin D system in skeletal muscle and resident myogenic stem cell during development, maturation, and ageing

Srikuea, Ratchakrit; Hirunsai, Muthita; Charoenphandhu, Narattaphol

doi:10.1038/s41598-020-65067-0

Cited by 23 publications

(25 citation statements)

References 48 publications

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“…Moreover, the cooperative action of vitamin D 3 and GCs in modulating gene expression was presented [ 17 ] which implies the potential reduction of the adverse effects of GC excess (during vitamin D 3 supplementation) [ 52 ]. In our study, this phenomenon is partly confirmed because SOL muscle consists of predominantly slow-oxidative fibers, with a larger pool of mitochondria, and EDL is mainly formed of fast-glycolytic muscle fibers [ 53 ]. Our results show that in DEX-induced atrophy rats, SOL muscle is sparing in both absolute ( Figure 5 A) and relative values ( Figure 6 A).…”

Section: Discussionsupporting

confidence: 60%

The Positive Impact of Vitamin D on Glucocorticoid-Dependent Skeletal Muscle Atrophy

et al. 2021

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(1) The study aimed to investigate whether vitamin D3 supplementation would positively affect rats with glucocorticoids-induced muscle atrophy as measured by skeletal muscle mass in two experimental conditions: chronic dexamethasone (DEX) administration and a model of the chronic stress response. (2) The study lasted 28 consecutive days and was performed on 45 male Wistar rats randomly divided into six groups. These included two groups treated by abdominal injection of DEX at a dose of 2 mg/kg/day supplemented with vegetable oil (DEX PL; n = 7) or with vitamin D3 600 IU/kg/day (DEX SUP; n = 8), respectively, and a control group treated with an abdominal injection of saline (CON; n = 6). In addition, there were two groups of rats chronically stressed by cold water immersion (1 hour/day in a glass box with 1-cm-deep ice/water mixture; temperature ~4 °C), which were supplemented with vegetable oil as a placebo (STR PL; n = 9) or vitamin D3 at 600 IU/kg/day (STR SUP; n = 9). The last group was of sham-stressed rats (SHM; n = 6). Blood, soleus, extensor digitorum longus, gastrocnemius, tibialis anterior, and quadriceps femoris muscles were collected and weighed. The heart, liver, spleen, and thymus were removed and weighed immediately after sacrifice. The plasma corticosterone (CORT) and vitamin D3 metabolites were measured. (3) We found elevated CORT levels in both cold water-immersed groups; however, they did not alter body and muscle weight. Body weight and muscle loss occurred in groups with exogenously administered DEX, with the exception of the soleus muscle in rats supplemented with vitamin D3. Decreased serum 25(OH)D3 concentrations in DEX-treated rats were observed, and the cold water immersion did not affect vitamin D3 levels. (4) Our results indicate that DEX-induced muscle loss was abolished in rats supplemented with vitamin D3, especially in the soleus muscle.

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Section: Discussionsupporting

confidence: 60%

The Positive Impact of Vitamin D on Glucocorticoid-Dependent Skeletal Muscle Atrophy

et al. 2021

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“…In skeletal muscle of mature and aged mice, protein expression of VDR is closely associated with serum concentration of 25(OH)D (Srikuea et al, 2020). The VDR and vitamin D-activating enzyme CYP27B1 are lowly expressed in homeostatic skeletal muscle in vitro and in vivo, evidenced by immunocytochemical and immunohistochemical visualization and immunoblotting in both C2C12 myoblasts and whole mouse muscle (Srikuea et al, 2012(Srikuea et al, , 2020. After muscle injury, the minimal expression of VDR and CYP27B1 observed in homeostatic conditions is starkly augmented.…”

Section: Skeletal Muscle Damage and Regeneration Throughout The Lifespanmentioning

confidence: 99%

“…In mice, VDR protein expression is increasingly elevated from development through maturation and aging (Srikuea et al, 2020); however, a study in human muscle showed an inverse relationship between skeletal muscle VDR expression and age (Bischoff-Ferrari et al, 2004). VDR expression is strongly associated with changes in circulating 25(OH)D concentrations following vitamin D 3 supplementation in older women with vitamin D insufficiency (25OHD of 46.3 ± 9.5 nmol/L; Ceglia et al, 2013).…”

Section: Skeletal Muscle Damage and Regeneration Throughout The Lifespanmentioning

confidence: 99%

“…VDR expression is strongly associated with changes in circulating 25(OH)D concentrations following vitamin D 3 supplementation in older women with vitamin D insufficiency (25OHD of 46.3 ± 9.5 nmol/L; Ceglia et al, 2013). In mice, elevated VDR expression in aged skeletal muscle is also associated with central nucleation of muscle fibers (Srikuea et al, 2020) typically indicative of muscle fibers recovering from a damaging stimulus. Further understanding the environment facilitating deficits in muscle regeneration, and perhaps the contribution of vitamin D signaling, could lead to the development of novel therapeutic strategies that support greater myogenic potential throughout the lifespan.…”

Section: Skeletal Muscle Damage and Regeneration Throughout The Lifespanmentioning

confidence: 99%

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Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health

et al. 2021

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Vitamin D is an essential nutrient for the maintenance of skeletal muscle and bone health. The vitamin D receptor (VDR) is present in muscle, as is CYP27B1, the enzyme that hydroxylates 25(OH)D to its active form, 1,25(OH)D. Furthermore, mounting evidence suggests that vitamin D may play an important role during muscle damage and regeneration. Muscle damage is characterized by compromised muscle fiber architecture, disruption of contractile protein integrity, and mitochondrial dysfunction. Muscle regeneration is a complex process that involves restoration of mitochondrial function and activation of satellite cells (SC), the resident skeletal muscle stem cells. VDR expression is strongly upregulated following injury, particularly in central nuclei and SCs in animal models of muscle injury. Mechanistic studies provide some insight into the possible role of vitamin D activity in injured muscle. In vitro and in vivo rodent studies show that vitamin D mitigates reactive oxygen species (ROS) production, augments antioxidant capacity, and prevents oxidative stress, a common antagonist in muscle damage. Additionally, VDR knockdown results in decreased mitochondrial oxidative capacity and ATP production, suggesting that vitamin D is crucial for mitochondrial oxidative phosphorylation capacity; an important driver of muscle regeneration. Vitamin D regulation of mitochondrial health may also have implications for SC activity and self-renewal capacity, which could further affect muscle regeneration. However, the optimal timing, form and dose of vitamin D, as well as the mechanism by which vitamin D contributes to maintenance and restoration of muscle strength following injury, have not been determined. More research is needed to determine mechanistic action of 1,25(OH)D on mitochondria and SCs, as well as how this action manifests following muscle injury in vivo. Moreover, standardization in vitamin D sufficiency cut-points, time-course study of the efficacy of vitamin D administration, and comparison of multiple analogs of vitamin D are necessary to elucidate the potential of vitamin D as a significant contributor to muscle regeneration following injury. Here we will review the contribution of vitamin D to skeletal muscle regeneration following injury.

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“…Indeed, several studies have shown a link between periodontal disease and some frequent systemic pathologies [ 10 ] such as diabetes [ 11 ], cardiovascular disease [ 12 , 13 ], respiratory disease [ 14 ], obesity [ 15 ], cancer [ 16 , 17 ], and preterm birth (PTB) [ 7 ]. Vitamin D is a secosteroid that can be ascribed to steroid hormones if considering its biological effects on several tissues [ 18 , 19 , 20 , 21 , 22 ]. Vitamin D might affect periodontal disease both through an effect on bone mineral density and through immunomodulatory effects [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Periodontal Disease and Vitamin D Deficiency in Pregnant Women: Which Correlation with Preterm and Low-Weight Birth?

Ferrillo

Migliario

Roccuzzo

et al. 2021

JCM

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Periodontal disease seems to be correlated with low vitamin D serum levels, preterm birth (PTB) and low birth weight (LBW), although the literature still lacks a consensus. This study aimed to investigate this correlation in a cohort of pregnant women over 20 weeks of gestation from the University Hospital “Maggiore della Carità”, Novara, Italy. We assessed serum levels of vitamin D and oral health status through the following indexes: Oral Hygiene Index (OHI), Plaque Control Record (PCR), Gingival Bleeding Index (GBI), and Community Periodontal Index of Treatment Needs (CPTIN). Moreover, we assessed the number of PTB and LBW among the newborns. Out of 121 pregnant women recruited, 72 (mean age 29.91 ± 3.64 years) were included. There was a statistically significant correlation between preterm and OHI > 3 (p = 0.033), and between LBW and OHI > 3 (p = 0.005) and CPITN = 3 (p = 0.027). Both pregnant women with vitamin D deficiency ((25-hydroxy-vitamin D) < 30 ng/mL) and PTB plus LBW newborns were significantly correlated (p < 0.05) with poor levels of all oral health status indexes during pregnancy. Furthermore, these conditions (women with hypovitaminosis D and combination of PTB and LBW) were shown to be significantly correlated (p < 0.001). Taken together, our findings reported a high prevalence of PTB and LBW with poor oral health and vitamin D deficiency in pregnant women.

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Regulation of vitamin D system in skeletal muscle and resident myogenic stem cell during development, maturation, and ageing

Cited by 23 publications

References 48 publications

The Positive Impact of Vitamin D on Glucocorticoid-Dependent Skeletal Muscle Atrophy

The Positive Impact of Vitamin D on Glucocorticoid-Dependent Skeletal Muscle Atrophy

Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health

Periodontal Disease and Vitamin D Deficiency in Pregnant Women: Which Correlation with Preterm and Low-Weight Birth?

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