Regulation of Wolffian Duct Development

Hannema, Sabine E.; Hughes, Ieuan A.

doi:10.1159/000096644

Cited by 130 publications

(122 citation statements)

References 120 publications

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“…In males, sexual differentiation develops through regression of the Müllerian ducts and the development of the Wolffian ducts into multiple reproductive organs, such as the epididymis, the vas deferens ducts and the the seminal vesicles. In females, the Wolffian ducts regress and the Müllerian ducts differentiate to form the uterus, the fallopian tubes, and the proximal vagina (Hannema & Hughes, 2007;Kobayashi & Behringer, 2003).…”

Section: The Prenatal Development Of the Epididymismentioning

confidence: 99%

“…The major morphogenic event during Wolffian duct/epididymal duct development is the elongation and coiling of the duct (Hannema & Hughes, 2007). The process of elongation is likely a product of potential mechanisms such as cell proliferation coupled with directed cell rearrangements, along with the interactions between the Wolffian duct ephitelium and the surrounding mesenchyme cells (Hinton et al, 2011).…”

Section: The Prenatal Development Of the Epididymismentioning

confidence: 99%

“…These ductules open into the epididymis (Figure 2). Distal to the epididymis, the Wolffian ducts acquire a thicker investment of smooth muscle and become the ductus deferens (Moore & Persaud, 2003;Hannema & Hughes, 2007). Fig.…”

Section: The Prenatal Development Of the Epididymismentioning

confidence: 99%

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The Epididymis: Embryology, Structure, Function And Its Role In Fertilization And Infertility

Arroteia¹,

García²,

Barbieri³

et al. 2012

Embryology - Updates and Highlights on Classic Topics

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Embryology is a branch of science concerned with the morphological aspects of organismal development. The genomic and molecular revolution of the second half of the 20th century, together with the classic descriptive aspects of this science have allowed greater integration in our understanding of many developmental events. Through such integration, modern embryology seeks to provide practical knowledge that can be applied to assisted reproduction, stem cell therapy, birth defects, fetal surgery and other fields. This book focuses on human embryology and aims to provide an up-to-date source of information on a variety of selected topics. The book consists of nine chapters organized into three sections, namely: 1) gametes and infertility, 2) implantation, placentation and early development, and 3) perspectives in embryology. The contents of this book should be of interest to biology and medical students, clinical embryologists, laboratory researchers, obstetricians and urologists, developmental biologists, molecular geneticists and anyone who wishes to know more about recent advances in human development.

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Section: The Prenatal Development Of the Epididymismentioning

confidence: 99%

Section: The Prenatal Development Of the Epididymismentioning

confidence: 99%

See 1 more Smart Citation

The Epididymis: Embryology, Structure, Function And Its Role In Fertilization And Infertility

Arroteia¹,

García²,

Barbieri³

et al. 2012

Embryology - Updates and Highlights on Classic Topics

View full text Add to dashboard Cite

show abstract

“…The epididymis consists of a single coiled tubular duct and has a polarized epithelial layer surrounded by a smooth muscle layer (Sullivan, 2004). During embryonic development, under the influence of androgens secreted from the male gonad, the Wolffian ducts develop into a number of male reproductive organs, such as the epididymis, vas deferens, and seminal vesicles (Hannema and Hughes, 2007). In general, the differentiation of epididymal epithelial cells appears in two developmental phases during postnatal development a first phase in the early neonatal period, in which halo cells appear from undifferentiated cells, and a second phase, in which there is a sequential differentiation of other cell types until adulthood (Arrotéia et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The Expression Patterns of Connexin Isoforms in the Rat Caput Epididymis During Postnatal Development

Han¹,

Lee²

2013

Journal of Animal Science and Technology

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Intercellular interactions are important for the proper development and regulation of tissue function. This is especially necessary in the epididymis, a part of male reproductive tract where sperm become mature and acquire their fertilizing capacity. The caput region of the epididymis consists of several types of cells, including principal, basal, and apical cells. Direct intercellular communication is thus required to precisely regulate the functions of the caput epididymis. In this regard, connexin (Cx) is a molecule that forms channels, which allow the direct exchange of small molecules between cells, enabling intercellular communication. In this study, the expression of Cx isoforms in the caput epididymis at different postnatal ages was determined by using quantitative real-time polymerase chain reaction analysis. Nine of 13 Cx isoforms were detected. The transcript levels of Cx30.3, 31, 31.1, 32, and 40 were highest at 45 days of age, while the expression of Cx43 and 45 gradually decreased with age. A substantial fluctuation of Cx26 expression was detected, with significant decreases before and during puberty, followed by a transient increase at adult-hood and rapid decreases at an old age. A significant increase in Cx37 transcript was observed at 25 days of age, followed by gradual decreases at adult and old ages. These results indicate the significant differential expression of various Cx isoforms in the caput epididymis during postnatal development. It further suggests that the functional regulation and developmental maturation of the caput epididymis are highly related to the postnatal age-related differential expression of Cx isoforms.

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“…13 From the eighth/ninth week on, Leydig cells begin to produce testosterone, which stabilizes the Wolffian ducts and allows them to differentiate into the epididymis, vas deferens, seminal vesicle and ejaculatory duct. The local action of testosterone on the Wolffian ducts is much more important than its systemic action, to the extent that each testicle is also responsible for the differentiation of the Wolffian duct on its own side 14 The prostate emerges, around the 10th week, by evagination from the urogenital sinus. Human chorionic gonadotropin (hCG) is produced by syncytiotrophoblasts, stimulating Leydig cells to secrete testosterone during the critical period of male sex differentiation.…”

Section: Introductionmentioning

confidence: 99%

O pediatra frente a uma criança com ambigüidade genital

Guerra‐Júnior¹,

Maciel‐Guerra²

2007

J. Pediatr. (Rio J.)

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Objective:To present the diagnostic criteria of genital ambiguity, the initial medical management and the attitude expected of pediatricians. Sources:Review of the scientific literature in the form of articles indexed on MEDLINE, in English and Portuguese, published between 1990 and 2007 and dealing with the pediatric age group. Summary of the findings:Pediatricians have a fundamental role to play in the assessment of genital ambiguity, the purpose of which is to arrive at an etiologic diagnosis in the shortest possible time in order to define the patient's sex and plan treatment. There are specific diagnostic criteria, but, in general, genitalia are ambiguous whenever there is difficulty in attributing gender to a child. The pediatrician should inform the patient's family that assignment of their child's sex will depend upon detailed laboratory investigations, preferably carried out by a multidisciplinary team at a tertiary service. The 46,XX or 46,XY karyotypes are not alone sufficient to define the gender of rearing, although the test is fundamental to guide the investigation. When there are no palpable gonads, the first hypothesis should be congenital adrenal hyperplasia. Other causes included partial androgen insensitivity, 5α-reductase deficiency, partial gonadal dysgenesis and hermaphroditism. The family should be provided with support and information throughout the assessment process, and their participation is fundamental in the decision of which gender to rear the child in.Conclusions: Although cases of genital ambiguity are relatively rare for pediatricians, they should be wellinformed on the subject and the correct management of these conditions, since they will often be responsible for the initial guidance that families receive and for maintaining contact between them and the multidisciplinary team.J Pediatr (Rio J). 2007;83(5 Suppl):S184-191: Ambiguity, determination, differentiation, genitalia, intersex.

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Regulation of Wolffian Duct Development

Cited by 130 publications

References 120 publications

The Epididymis: Embryology, Structure, Function And Its Role In Fertilization And Infertility

The Epididymis: Embryology, Structure, Function And Its Role In Fertilization And Infertility

The Expression Patterns of Connexin Isoforms in the Rat Caput Epididymis During Postnatal Development

O pediatra frente a uma criança com ambigüidade genital

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