Regulation of μ‐opioid type 1 receptors by microRNA134 in dorsal root ganglion neurons following peripheral inflammation

Abstract

Our present data suggested a model that miR-134 participated in CFA-induced inflammatory pain by balancing the expression of MOR1 in DRGs, which implied that miR-134 may be a potential therapeutic target for the treatment of neuropathic pain including inflammation.

Practical Considerations of Convection Enhanced Delivery for Novel Therapies Treating Spinal Cord Injury Related Neuropathic Pain

“…Out of 111 miRNAs, 68% reported earlier and 32% related to the development of tumors of the nervous system and neurodegenerative diseases, few miRNAs, including miR-500, miR-221 and miR-21, relate to CCI-induced NP [79]. In another study miR-134, expression level found inversely related to MOR, the main transcript of μ-opioid receptor (MOR) gene expression [75]. Post inflammatory pain observations included the down-regulation of miR-134 and upregulation of MOR1 in the same tissues.…”

“…The expression and function of miRNA in different animal pain models needs to consider due to the challenge of application and delivery of miRNA in vivo, the potential toxic effects of miRNA and future problems in clinical application [74]. Furthermore, an existing model of miR-134 shows a balanced expression of MOR1 in DRGs in CFA-induced inflammatory pain, which implies that miR-134 may be a potential therapeutic target for the treatment of neuropathic pain including inflammation [75].…”

MicroRNA Biology and Pain

“…[89][90][91][92][93] Some have successfully provided the proof-of concept for a role of specific miRNAs in influencing behavior using rodent models 79,94-96 (Fig. 4).…”

Role of MicroRNA in Visceral Pain

“…This finding strongly suggests the involvement of miRNAs in long-term cortical plasticity following esophageal acid exposure early in life. Here, we review specific miRNAs that have been identified as the regulators of nociceptive activity and highlight their possible association with pain processing in various pain conditions (Table 87, 99,100,101,103,[105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122] ).…”