Regulator of G-protein signaling 4: A novel tumor suppressor with prognostic significance in non-small cell lung cancer

Cheng, Chih‐Tao; Yue, Weiming; Li, Lin; Li, Shuhai; Gao, Cun; Si, Libo; Tian, Hui

doi:10.1016/j.bbrc.2015.11.110

Cited by 20 publications

(26 citation statements)

References 26 publications

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“…For the first time, our studies found that the expression of RGS4 in melanoma tissues was lower than that of melanocyte nevus tissues. This result is consistent with the RGS4 expression pattern in breast tumor and NSCLC [ 28 , 29 ]. RGS4 expression reduction is significantly correlated with positive lymph node metastasis and advanced TNM stage [ 29 ].…”

Section: Discussionsupporting

confidence: 89%

“…This result is consistent with the RGS4 expression pattern in breast tumor and NSCLC [ 28 , 29 ]. RGS4 expression reduction is significantly correlated with positive lymph node metastasis and advanced TNM stage [ 29 ]. In our study, RGS4 expression and TNM stage were interrelated in clinic pathological factors by immunohistochemistry.…”

Section: Discussionsupporting

confidence: 89%

“…Previous studies indicated that RGS4 notably inhibited invasion and migration of breast cancer cells by its GAP-mediated activity [ 28 ]. Consistent inhibition was observed in NSCLC cells [ 29 ]. However, the physiological function of RGS4 in malignant melanoma is not well known so far.…”

Section: Discussionsupporting

confidence: 65%

“…Meanwhile, knockdown of RGS4 can achieve the completely opposite results. On the other hand, functioning as a tumor suppressor, RGS4 inhibited tumor metastasis and invasiveness by regulating EMT-related markers and MMPs [ 29 ]. Matrix metalloproteinases (MMPs) are the primary agents responsible for ECM degradation and their abnormal expression link to the progression of many cancers, including melanoma [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…RGS4 may inhibit the migration and invasion of breast cancer cells via down-regulating the metastasis-associated Gi-coupled receptors (PAR1 and CXCR4) signal transduction [ 28 ]. RGS4 is also found in NSCLC cells and its overexpression decreases invasion and migration by inhibiting MMP2/9 and reversing EMT [ 29 ]. These studies together demonstrate the importance of RGS4 in multiple cell functions.…”

Section: Introductionmentioning

confidence: 99%

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Regulator of G protein signaling 4 inhibits human melanoma cells proliferation and invasion through the PI3K/AKT signaling pathway

et al. 2017

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Melanoma is a tumor produced by skin melanocytes, which has a high metastatic rate and poor prognosis. So far, plenty of work has been done on melanoma, but mechanisms underlying melanoma development have not been fully elucidated. Here we identified regulator of G protein signaling 4(RGS4) as novel therapeutic target for malignant melanoma and its regulating effect on melanoma. We found that endogenous RGS4 expression was much lower in melanoma tissues and cells. In A375 cell line with low endogenous RGS4 expression, the function of RGS4 was detected by up-regulation its expression with pcDNA3.1-RGS4 and knockdown its expression with siRNA. Our results showed that RGS4 could significantly reduce the proliferation, migration and invasion of melanoma cells. RGS4 is an important regulator for the apoptosis of melanocyte, and the apoptosis rate is significantly decreased in low RGS4 enviroment. RGS4 induced non-activation of PI3K/AKT pathway, resulting in decreased expression of E2F1 and Cyclin D1, thus constraining cell proliferation and invasion. These results were further confirmed in M14 cell lines. Collectively, our findings show that RGS4 plays an important role in multiple cellular functions of melanoma development and is valuable to be a therapeutic target.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regulator of G protein signaling 4 inhibits human melanoma cells proliferation and invasion through the PI3K/AKT signaling pathway

et al. 2017

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A broad analysis in clinical and in vitro models on regulator of G‐protein signalling 10 regulation that is associated with ovarian cancer progression and chemoresistance

Kucuk

Kibar

Çaçan

2020

Cell Biochemistry & Function

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Ovarian cancer is one of the deadliest types of gynaecological cancers and more than half of the patients die within 5 years after diagnosis. Recurrence in advanced staged patients after chemotherapy is associated with increased chemoresistance, which results in poor prognosis. Regulator of G‐protein signalling 10 (RGS10) negatively regulates cell proliferation, migration and survival by attenuating G‐protein coupled‐receptors mediated signalling pathways. Recent studies have shown that loss of RGS10 expression is significantly associated with proliferation and cisplatin resistance in ovarian cancer cells. Significance of the study In this study, we analysed differential RGS10 expression levels using public microarray datasets from clinical and in vitro ovarian cancer samples. We validated that cancer progression and chemotherapy exposure change RGS10 expression. We enriched our study to evaluate the relationship between chemoresistance and differential RGS10 expression against ovarian cancer potential chemotherapeutic agent, palbociclib. Results showed that palbociclib treatment reduced cell viability, despite significantly decreased RGS10 expression in chemoresistant cells. Overall, the results confirmed that cancer progression and chemoresistance are significantly associated with the down‐regulation of RGS10 while some chemotherapeutics seem to be beneficial in decreasing chemoresistance in ovarian cancer.

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LncRNA KCNQ1OT1 acting as a ceRNA for miR-4458 enhances osteosarcoma progression by regulating CCND2 expression

Wang

Zhu

et al. 2019

In Vitro Cell.Dev.Biol.-Animal

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Regulator of G-protein signaling 4: A novel tumor suppressor with prognostic significance in non-small cell lung cancer

Cited by 20 publications

References 26 publications

Regulator of G protein signaling 4 inhibits human melanoma cells proliferation and invasion through the PI3K/AKT signaling pathway

Regulator of G protein signaling 4 inhibits human melanoma cells proliferation and invasion through the PI3K/AKT signaling pathway

A broad analysis in clinical and in vitro models on regulator of G‐protein signalling 10 regulation that is associated with ovarian cancer progression and chemoresistance

LncRNA KCNQ1OT1 acting as a ceRNA for miR-4458 enhances osteosarcoma progression by regulating CCND2 expression

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