Regulatory and academic studies to derive reference values for human health: The case of bisphenol S

Beausoleil, Claire; Magueresse-Battistoni, Brigitte Le; Viguié, Catherine; Babajko, Sylvie; Canivenc-Lavier, Marie-Chantal; Chevalier, Nicolas; Emond, Claude; Habert, René; Picard‐Hagen, Nicole; Mhaouty-Kodja, Sakina

doi:10.1016/j.envres.2021.112233

Cited by 29 publications

(29 citation statements)

References 157 publications

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“…The human data analysed by Beausoleil et al (2022) were considered insufficient for establishing a relationship between internal concentrations and relevant health effects [ 25 ]. In addition, neither toxicity reference values nor occupational exposure limits have been proposed by the EU or by any relevant non-EU organisations so far.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding workers, the scarcity of data on occupational exposure does not allow for assessment of the relationship between atmospheric concentrations of BPS and total urinary concentrations of BPS. Thus, the derivation method for HBM-GVs for BPS for both the general population and the workers was based on a point of departure (POD) identified from animal experimental studies, as tentatively proposed by Beausoleil et al, 2022 [ 25 ]. The HBM-GVs were then derived by translating the POD into the corresponding urinary levels in humans for the selected biomarker of exposure by using a PBPK model.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the third option is to derive an HBM-GV based on critical effects observed in animal studies. The choice of POD is based on the recommendation formulated by Beausoleil et al (2022) who reviewed regulatory toxicology studies conducted in accordance with OECD Test Guidelines, as well as numerous academic studies investigating more specific parameters dedicated to endocrine disrupting effects [ 25 ]. Adverse effects due to BPS exposure were reported in academic studies assessing male and female reproduction, mammary glands, neurobehavior and metabolism/obesity.…”

Section: Resultsmentioning

confidence: 99%

“…LOAELs regarding developmental exposure to BPS were far lower in academic studies than in regulatory ones and were expressed, respectively, in µg/kg bw/day vs. mg/kg bw/day. Beausoleil et al (2022) proposed to derive a HBM-GV from values determined in academic peer-reviewed experimental studies [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…No risk assessment has yet been published for BPS, but several initiatives are underway. The toxicological profile of BPS has however been studied by Beausoleil et al (2022) [ 25 ]. There is a fairly large body of data on the toxicity of BPS, including repeated dose toxicity, reproductive toxicity and also specific effects on the endocrine system.…”

Section: Introductionmentioning

confidence: 99%

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Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Meslin

Beausoleil

Zeman

et al. 2022

Toxics

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Within the European Joint Programme HBM4EU, Human Biomonitoring Guidance Values (HBM-GVs) were derived for several prioritised substances. In this paper, the derivation of HBM-GVs for the general population (HBM-GVGenPop) and workers (HBM-GVworker) referring to bisphenol S (BPS) is presented. For the general population, this resulted in an estimation of the total urinary concentration of BPS of 1.0 µg/L assuming a 24 h continuous exposure to BPS. For workers, the modelling was refined in order to reflect continuous exposure during the working day, leading to a total urinary concentration of BPS of 3.0 µg/L. The usefulness for risk assessment of the HBM-GVs derived for BPS and bisphenol A (BPA) is illustrated. Risk Characterisation Ratios (RCRs) were calculated leading to a clear difference between risk assessments performed for both bisphenols, with a very low RCR regarding exposure to BPA., contrary to that obtained for BPS. This may be due to the endocrine mediated endpoints selected to derive the HBM-GVs for BPS, whereas the values calculated for BPA are based on the temporary Tolerable Daily Intake (t-TDI) from EFSA set in 2015. A comparison with the revised TDI recently opened for comments by EFSA is also discussed. Regarding the occupational field, results indicate that the risk from occupational exposure to both bisphenols cannot be disregarded.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Meslin

Beausoleil

Zeman

et al. 2022

Toxics

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In silico analysis of endocrine‐disrupting potential of triclosan, bisphenol A, and their analogs and derivatives

Đurić,

Milanović,

Drljača Lero

et al. 2024

J of Applied Toxicology

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Owning to the increasing body of evidence about the ubiquitous exposure to endocrine disruptors (EDCs), particularly bisphenol A (BPA), and associated health effects, BPA has been gradually substituted with insufficiently tested structural analogs. The unmanaged excessive use of antimicrobial agents such as triclosan (TCS) during the COVID‐19 outbreak has also raised concerns about its possible interferences with hormonal functions. The similarity of BPA and estradiol, as well as TCS and non‐steroidal estrogens, imply that endocrine‐disrupting properties of their analogs could be predicted based on the chemical structure. Hence, this study aimed to evaluate the endocrine‐disrupting potential of BPA substitutes as well as TCS derivatives and degradation/biotransformation metabolites, in comparison to BPA and TCS based on their molecular properties, computational predictions of pharmacokinetics and binding affinities to nuclear receptors. Based on the obtained results several under‐researched BPA analogs exhibited higher binding affinities for nuclear receptors than BPA. Notable analogs included compounds detected in receipts (DD‐70, BTUM‐70, TGSA, and BisOPP‐A), along with a flame retardant, BDP. The possible health hazards linked to exposure to TCS and its mono‐hydroxylated metabolites were also found. Further research is needed in order to elucidate the health impacts of these compounds and promote better regulation practices.

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Cytotoxic and genotoxic evaluation of bisphenol S on onion root tips by Allium cepa and comet tests

Ali

Fatima

Nawaz

et al. 2022

Environ Sci Pollut Res

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Regulatory and academic studies to derive reference values for human health: The case of bisphenol S

Cited by 29 publications

References 157 publications

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

In silico analysis of endocrine‐disrupting potential of triclosan, bisphenol A, and their analogs and derivatives

Cytotoxic and genotoxic evaluation of bisphenol S on onion root tips by Allium cepa and comet tests

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