Regulatory and Ethical Considerations

Ferry, Barbara; Gervasoni, Damien; Vogt, Catherine

doi:10.1007/978-2-8178-0472-9_1

Cited by 1 publication

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References 10 publications

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“…The foot skin was dissected and prepared for histological examination. All experiments were performed in accordance with the Chinese regulations on the use and breeding of experimental animals ( 19 ).…”

Section: Methodsmentioning

confidence: 99%

Paeoniflorin inhibits proliferation and promotes autophagy and apoptosis of sweat gland cells

et al. 2021

Exp Ther Med

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Axillary bromhidrosis is sweat excreted by apocrine glands in the armpits, mouth corners and other parts. The clinical manifestation includes excessive sweating and heavy odor, leading to the growth of bacteria and skin disease. The present study investigated the mechanism underlying the effect of paeoniflorin (PF) in the treatment of bromhidrosis. PF was injected into the feet of rats, and the foot skin was dissected for histological analysis. Primary human sweat gland cells (hSGCs) were isolated from patients with bromhidrosis. After 24 h treatment with PF or 3-methyladenine, the production of reactive oxygen species (ROS), autophagy, apoptosis, proliferation and cell cycle distribution were determined. PF induced nuclear pyknosis in rat SGCs. In vitro PF treatment inhibited cell proliferation with a 25% inhibitory concentration of 9.530 µM. Treatment with 9.530 µM PF for 24 h significantly increased apoptosis, ROS production and autophagy in hSGCs. PF promoted LC3B and Beclin 1 expression, but inhibited p62, phosphorylated (p)-PI3K and p-Akt expression. 3-methyladenine treatment reversed PF-induced changes in hSGCs. PF-induced inhibition of hSGC proliferation was associated with ROS production, apoptosis, and autophagy. These findings provide a basis for treating bromhidrosis.

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Section: Methodsmentioning

confidence: 99%

Paeoniflorin inhibits proliferation and promotes autophagy and apoptosis of sweat gland cells

et al. 2021

Exp Ther Med

View full text Add to dashboard Cite

show abstract

Regulatory and Ethical Considerations

Cited by 1 publication

References 10 publications

Paeoniflorin inhibits proliferation and promotes autophagy and apoptosis of sweat gland cells

Paeoniflorin inhibits proliferation and promotes autophagy and apoptosis of sweat gland cells

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