Regulatory Aspects of Nanomaterials in the EU

Rauscher, Hubert; Rasmussen, Kirsten; Sokull-Klüttgen, Birgit

doi:10.1002/cite.201600076

Cited by 165 publications

(76 citation statements)

References 3 publications

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“…Additionally, the impact of nanoparticles on the properties of the packaging films, such as barrier properties and transparency, should also be considered. However, the safety evaluation and approval for use of such nanoparticles in food packaging remains the greatest challenge due to the difficulties in the evaluation of the safety of nanoparticles in general (Radusin and others ) as well as constraints associated with the current legislative landscape (Amenta and others ; Radusin and others ; Rauscher and others ).…”

Section: Nanoparticlesmentioning

confidence: 99%

Active Packaging Applications for Food

Yildirim

Röcker

Pettersen

et al. 2017

Comp Rev Food Sci Food Safe

719

390

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The traditional role of food packaging is continuing to evolve in response to changing market needs. Current drivers such as consumer's demand for safer, "healthier," and higher-quality foods, ideally with a long shelf-life; the demand for convenient and transparent packaging, and the preference for more sustainable packaging materials, have led to the development of new packaging technologies, such as active packaging (AP). As defined in the European regulation (EC) No 450/2009, AP systems are designed to "deliberately incorporate components that would release or absorb substances into or from the packaged food or the environment surrounding the food." Active packaging materials are thereby "intended to extend the shelf-life or to maintain or improve the condition of packaged food." Although extensive research on AP technologies is being undertaken, many of these technologies have not yet been implemented successfully in commercial food packaging systems. Broad communication of their benefits in food product applications will facilitate the successful development and market introduction. In this review, an overview of AP technologies, such as antimicrobial, antioxidant or carbon dioxide-releasing systems, and systems absorbing oxygen, moisture or ethylene, is provided, and, in particular, scientific publications illustrating the benefits of such technologies for specific food products are reviewed. Furthermore, the challenges in applying such AP technologies to food systems and the anticipated direction of future developments are discussed. This review will provide food and packaging scientists with a thorough understanding of the benefits of AP technologies when applied to specific foods and hence can assist in accelerating commercial adoption.

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Section: Nanoparticlesmentioning

confidence: 99%

Active Packaging Applications for Food

Yildirim

Röcker

Pettersen

et al. 2017

Comp Rev Food Sci Food Safe

719

390

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“…Although they are composed of materials that are well known since decades, evaluation of engineered nanomaterials poses a particular regulatory challenge . The European Commission (EC) and the Food and Drug Administration (FDA) are directing efforts towards more unified testing and assessment criteria . In the past, membership to the family of nanomaterials was granted on the basis of physical dimensions; however, modern regulation and guidelines by the FDA and the EC are going away from this strict size dependence and extend the family also to microsized agglomerates.…”

Section: Regulatory and Toxicological Aspectsmentioning

confidence: 99%

Lignin for Nano‐ and Microscaled Carrier Systems: Applications, Trends, and Challenges

et al. 2019

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To liberate society from its dependence on fossil‐based fuels and materials it is pivotal to explore components of renewable plant biomass in applications that benefit from their intrinsic biodegradability, safety, and sustainability. Lignin, a byproduct of the pulp and paper industry, is a plausible material for carrying various types of cargo in small‐ and large‐scale applications. Herein, possibilities and constraints regarding the physical–chemical properties of the lignin source as well as modifications and processing required to render lignins suitable for the loading and release of pesticides, pharmaceuticals, and biological macromolecules is reviewed. In addition, the technical challenges, regulatory and toxicological aspects, and future research needed to realize some of the promises that nano‐ and microscaled lignin materials hold for a sustainable future are critically discussed.

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“…Nanoparticles (NPs) are NMs that have all three dimensions between 1 and 100 nm. A material can also be considered as a NM if its volume-specific surface area is larger than 60 m 2 cm À3 (Rauscher et al, 2017). However, the term NM in nanomedicine extends this commonly accepted definition to particles with dimensions up to 1000 nm (Schütz et al, 2013a).…”

Section: Introductionmentioning

confidence: 99%

Nanomedicine and epigenome. Possible health risks

Smolkova

Dušinská

Gábelová

2017

Food and Chemical Toxicology

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a b s t r a c tNanomedicine is an emerging field that combines knowledge of nanotechnology and material science with pharmaceutical and biomedical sciences, aiming to develop nanodrugs with increased efficacy and safety. Compared to conventional therapeutics, nanodrugs manifest higher stability and circulation time, reduced toxicity and improved targeted delivery. Despite the obvious benefit, the accumulation of imaging agents and nanocarriers in the body following their therapeutic or diagnostic application generates concerns about their safety for human health. Numerous toxicology studies have demonstrated that exposure to nanomaterials (NMs) might pose serious risks to humans. Epigenetic modifications, representing a non-genotoxic mechanism of toxicant-induced health effects, are becoming recognized as playing a potential causative role in the aetiology of many diseases including cancer. This review i) provides an overview of recent advances in medical applications of NMs and ii) summarizes current evidence on their possible epigenetic toxicity. To discern potential health risks of NMs, since current data are mostly based upon in vitro and animal models, a better understanding of functional relationships between NM exposure, epigenetic deregulation and phenotype is required.

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Regulatory Aspects of Nanomaterials in the EU

Cited by 165 publications

References 3 publications

Active Packaging Applications for Food

Active Packaging Applications for Food

Lignin for Nano‐ and Microscaled Carrier Systems: Applications, Trends, and Challenges

Nanomedicine and epigenome. Possible health risks

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