Regulatory B cells in infectious disease

Dai, Youchao; Zhong, Jixin; Xu, Jun‐Fa

doi:10.3892/mmr.2017.6605

Cited by 53 publications

(47 citation statements)

References 55 publications

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“…This regulatory function is associated with their production of anti‐inflammatory cytokines, such as IL‐35, TGF‐β and, in particular, IL‐10 . Previous studies have shown that Breg cells, through the production of IL‐10, suppress pathogenic T cells and inhibit autoimmune inflammatory diseases such as arthritis, experimental autoimmune encephalomyelitis (EAE) and colitis, as well as contact hypersensitivity . Moreover, Breg cell transfer can effectively reverse autoimmune diseases in murine models, such as mice with experimental collagen‐induced arthritis (CIA) and lupus‐prone mice .…”

Section: Introductionmentioning

confidence: 99%

“…2 Previous studies have shown that Breg cells, through the production of IL-10, suppress pathogenic T cells and inhibit autoimmune inflammatory diseases such as arthritis, experimental autoimmune encephalomyelitis (EAE) and colitis, as well as contact hypersensitivity. [3][4][5] Moreover, Breg cell transfer can effectively reverse autoimmune diseases in murine models, such as mice with experimental collagen-induced arthritis (CIA) and lupus-prone mice. 6,7 However, the current understanding of the mechanisms of Breg expression and production of IL-10 remains rudimentary.…”

Section: Introductionmentioning

confidence: 99%

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Transcription factor c‐Maf is essential for IL‐10 gene expression in B cells

Liu

Zhao

et al. 2018

Scand J Immunol

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Interleukin (IL)-10 is an essential anti-inflammatory cytokine that plays important roles as a negative regulator of immune responses to microbial antigens. c-Maf has been suggested as an essential transcriptional factor for IL-10 production in CD4 T cells and macrophages. However, it remains unclear whether c-Maf participates in IL-10 expression in B cells. In this study, we investigated the role of c-Maf in the transcriptional regulation of IL-10 in regulatory B cells, as well as the underlying molecular mechanism. We found that c-Maf was constitutively expressed in resting B cells. c-Maf expression was upregulated in the presence of LPS and dose-dependently enhanced IL-10 production following binding to the IL-10 promoter. Moreover, a lower expression of c-Maf and decreased production of regulatory B (Breg) cells were detected in mice with collagen-induced arthritis (CIA), which may contribute to the pathological changes. Taken together, these data demonstrate that c-Maf is an indispensable yet constitutive transcription factor for IL-10 gene expression in LPS-activated B cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transcription factor c‐Maf is essential for IL‐10 gene expression in B cells

Liu

Zhao

et al. 2018

Scand J Immunol

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“…In particular, the regulatory role of B cells was recently described in different diseases and immune conditions, including autoimmunity (1), allergy (2), cancer (3), and infection (4). However, B cells can also modulate the function of other immune cells by producing cytokines or presenting antigens.…”

Section: Introductionmentioning

confidence: 99%

“…However, B cells can also modulate the function of other immune cells by producing cytokines or presenting antigens. In particular, the regulatory role of B cells was recently described in different diseases and immune conditions, including autoimmunity (1), allergy (2), cancer (3), and infection (4). Regulatory B cells (Breg) have been shown to induce regulatory T cells (Treg) (5) and modulate effector T cell functions by suppressing proliferation (6), cytokine production by stimulated CD4+ T cells (7), and differentiation of Th1 and Th17 cells (5,7).…”

Section: Introductionmentioning

confidence: 99%

Unstimulated Adult Human B Cells Include an IL‐10+ Population with Suppressive Properties and an Activated Phenotype

et al. 2018

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B cells with regulatory properties have been recently identified and described in different immune disorders, including autoimmunity, infection, cancer, and allergy. in vitro studies of regulatory B cells are usually performed following prolonged cell culture and stimulation in order to obtain B cells capable of IL-10 secretion. We describe the isolation of viable IL-10-positive B cells directly from ex vivo unstimulated samples using the IL-10 secretion assay from Miltenyi Biotec, which was originally designed for IL-10-positive T cell analysis and isolation. IL-10-positive B cells from unstimulated samples represented approximately 2% of all B cells in healthy individuals, suppressed T cell proliferation and were enriched for surface markers of B cell activation. This tool has a potential to boost functional studies of IL-10-secreting B cells in health and disease.

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“…28,29 Moreover, IL-35 and TGF-β have also been associated with B cellmediated immunosuppression in Salmonella infection in mice. 30 In fact, via IL-10, Bregs may also have a role in infectious diseases, particularly with respect to viral infections such as HIV and hepatitis B virus (HBV). In HBV, Bregs regulate antigen-specific CD8 + T cells during HBV infection.…”

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confidence: 99%