Regulatory B Cells: Role in Type 1 Diabetes

Boldison, Joanne; Wong, F. Susan

doi:10.3389/fimmu.2021.746187

Cited by 14 publications

(9 citation statements)

References 77 publications

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“…A decreased proportion of IL-10-producing Bregs with impaired suppressive activity has been recently reported in T1D patients [63 & ,64]. Although it is still unclear how Breg impairment contributes to T1D or whether it is a consequence of chronic inflammation [65], it cannot be excluded that they might also contribute to the lower induction of Tr1 cells.…”

Section: Interleukin-10-producing Type 1 T Regulatory Cells In Type 1...mentioning

confidence: 99%

Alteration of interleukin-10-producing Type 1 regulatory cells in autoimmune diseases

Gregori

Amodio

Passerini

et al. 2022

Current Opinion in Hematology

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Purpose of reviewThis review highlights findings describing the role of interleukin (IL)-10-producing Type 1 regulatory T (Tr1) cells in controlling autoimmune diseases and possible approaches to restore their function and number. Recent findingsReduced frequency and/or function of cell subsets playing a role in Tr1 cell induction (e.g., DC-10 and Bregs), was found in patients with autoimmunity and may impact on Tr1 cell frequency.

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Section: Interleukin-10-producing Type 1 T Regulatory Cells In Type 1...mentioning

confidence: 99%

Alteration of interleukin-10-producing Type 1 regulatory cells in autoimmune diseases

Gregori

Amodio

Passerini

et al. 2022

Current Opinion in Hematology

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“…Similarly, several paper also reported that peripheral blood circulating Bregs with CD19+CD1d+CD5+ phenotype were increased in patients with tuberculosis ( 51 , 52 ). Interestingly, Breg subsets were found and increased in patients with various autoimmune diseases, including ankylosing spondylitis ( 53 ), primary Sjögren’s syndrome ( 54 ), diabetes mellitus ( 55 ), multiple sclerosis and neuromyelitis optica spectrum disorders ( 56 ), etc., suggesting a close involvement of CD24++CD38++ B cells in the autoimmune pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Identification of autoimmune markers in pulmonary tuberculosis

et al. 2023

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IntroductionPathogenesis of many autoimmune diseases is mainly promoted by poorly regulated and/or wrong targeted immune response to pathogens including M. tuberculosis. Autoimmunity is one of the processes with are characteristics of tuberculosis (Tbc). The aim was to determine the autoimmune clinical and immunological features in patients with pulmonary Tbc.Materials and methodsA prospective comparative study was performed in 2017 – 2019 with the inclusion of 46 patients with Tbc. The trigger factors and clinical manifestations, autoantibodies, peripheral blood B cell subsets were stained with fluorochrome-conjugated monoclonal antibodies. 40 healthy volunteers in the control group, were matched for age with no chronic diseases, contacts with TB patients and changes in their laboratory parameters. A statistical analysis was done with GraphPad Prism 6, Statistica 10 (Statsoft) and MedCalc – version 18.2.1 values.ResultsThere were no significant ASIA triggers in Tbc patients and control group. 21.1% of Tbc patients had a high level of a rheumatoid factor and in 47.4% complement system factor C3 was high; anti-MCV was detected in 60.7% of Tbc patients. Relative and absolute frequencies of “naïve” Bm1 cells and eBm5 were significantly decreased and activated pre-germinal-center Bm2’ cells were significantly increased in Tbc patients. The CD24++CD38++ B cells were increased in Tbc vs control group (10.25% vs 5.42%), p < 0.001, and 19 cell/1μL (10; 290 vs 11 cell/1μL (6; 20), p = 0.029, respectively). The frequency of CXCR3+CCR4– Tfh1 cells was significantly lower in Tbc vs control one (26.52% vs. 31.00%, p = 0.004), while CXCR3–CCR4+ Tfh2 cells were increased in Tbc (20.31% vs. controls (16.56%, p = 0.030). The absolute numbers of Tfh1 cells were decreased in the Tbc vs. control (24 cell/1μL vs. 37 cell/1μL p = 0.005).ConclusionThe results of our study showed that the detection of a rheumatoid factor, the components of complement system and anti-MCV in complex with alterations in B cells and follicular Th cell subsets may indicate a presence of autoimmunity in the pathogenesis of tuberculosis, but they are not specific. The indicators of autoimmune-related provide new opportunities in the Tbc treatment.

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“…39 IL-10, IL-35 and TGF-β producing regulatory B-cells (B reg ) cells are protective in nature and their depletion triggers the switching of naïve B-cells to autoimmune B-cells. 40 In T1D, increased expression of Fas-ligand on IL-10 + B-cells is targeted by CD5 + Fas-L B-cells which causes the apoptosis of the former. Also, PD-L1:PD1 engagement causes increased B reg apoptosis.…”

Section: Changes In the Adaptive Immunity Compartmentmentioning

confidence: 99%

“…T regs control the mitochondrial oxidative phosphorylation (OXPHOS) in T eff cells in prediabetes and T2D and concomitantly support T h 1 or T h 17/T reg cytokine production 39 . IL‐10, IL‐35 and TGF‐β producing regulatory B‐cells (B reg ) cells are protective in nature and their depletion triggers the switching of naïve B‐cells to autoimmune B‐cells 40 . In T1D, increased expression of Fas‐ligand on IL‐10 + B‐cells is targeted by CD5 + Fas‐L B‐cells which causes the apoptosis of the former.…”

Section: Overview Of Alterations Of Immune Responses In Diabetic Indi...mentioning

confidence: 99%

“…In T1D, increased expression of Fas‐ligand on IL‐10 + B‐cells is targeted by CD5 + Fas‐L B‐cells which causes the apoptosis of the former. Also, PD‐L1:PD1 engagement causes increased B reg apoptosis 40 . IL10 + B reg cells and IL‐35 + B reg with anti‐inflammatory effects show decreased abundance in T1D patients suggestive of the inherent immune dysregulation in the individuals 41,42 Tim1 signal transduction is necessary for the maintenance and induction of IL‐10 in B reg .…”

Section: Overview Of Alterations Of Immune Responses In Diabetic Indi...mentioning

confidence: 99%

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Viral infection and host immune response in diabetes

Joshi,

Das,

Verma

et al. 2023

IUBMB Life

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Diabetes, a chronic metabolic disorder disrupting blood sugar regulation, has emerged as a prominent silent pandemic. Uncontrolled diabetes predisposes an individual to develop fatal complications like cardiovascular disorders, kidney damage, and neuropathies and aggravates the severity of treatable infections. Escalating cases of Type 1 and Type 2 diabetes correlate with a global upswing in diabetes‐linked mortality. As a growing global concern with limited preventive interventions, diabetes necessitates extensive research to mitigate its healthcare burden and assist ailing patients. An altered immune system exacerbated by chronic hyperinflammation heightens the susceptibility of diabetic individuals to microbial infections, including notable viruses like SARS‐CoV‐2, dengue, and influenza. Given such a scenario, we scrutinized the literature and compiled molecular pathways and signaling cascades related to immune compartments in diabetics that escalate the severity associated with the above‐mentioned viral infections in them as compared to healthy individuals. The pathogenesis of these viral infections that trigger diabetes compromises both innate and adaptive immune functions and pre‐existing diabetes also leads to heightened disease severity. Lastly, this review succinctly outlines available treatments for diabetics, which may hold promise as preventive or supportive measures to effectively combat these viral infections in the former.

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Regulatory B Cells: Role in Type 1 Diabetes

Cited by 14 publications

References 77 publications

Alteration of interleukin-10-producing Type 1 regulatory cells in autoimmune diseases

Alteration of interleukin-10-producing Type 1 regulatory cells in autoimmune diseases

Identification of autoimmune markers in pulmonary tuberculosis

Viral infection and host immune response in diabetes

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