Regulatory Effects Mediated by Enteromorpha prolifera Polysaccharide and Its Zn(II) Complex on Hypoglycemic Activity in High-Sugar High-Fat Diet-Fed Mice

Li, Liyan; Li, Yuanyuan; Wang, Peng

doi:10.3390/foods12152854

Cited by 5 publications

(1 citation statement)

References 57 publications

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“…We found that Firmicutes and Bacteroidota were the major phyla among the three groups, which was in line with previous findings [19,43,44]. In addition, increasing abundances of Clostridiaceae (Clostridium_sensu_stricto_1), f_Peptostreptococcaceae, f_Muribaculaceae, Terrisporobacter, Subdoligranulum and Intestinibacter were found in fecal samples, with the addition of different types and forms of Zn sources, which was found previously [44,45]. The potential pathogenic bacteria Clostridium_sensu_stricto_1, belonging to the Clostridiaceae family, was reported to produce SCFAs and promote intestinal mucus barrier adhesion to pathogens [46].…”

Section: Discussionsupporting

confidence: 92%

The Effect of Sodium Alginate-Coated Nano-Zinc Oxide on the Growth Performance, Serum Indexes and Fecal Microbial Structure of Weaned Piglets

Xiao,

Guo,

Liu

et al. 2023

Animals

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High dose of zinc oxide (ZnO) could improve growth performance and alleviate disease status, whereas it caused serious environmental pollution and bacterial resistance. This study was to investigate whether low doses of sodium alginate-coated nano zinc oxide (saZnO), a new type of zinc resource, could serve as a potential alternative to pharmacological doses of traditional ZnO in weaned piglets. A total of 144 crossbred piglets were randomly allocated into three groups, including a basal diet without the addition of Zn (CON), a basal diet with 1600 mg Zn/kg from traditional ZnO (ZnO), and a basal diet with 500 mg Zn/kg from saZnO (saZnO). The experiment lasted for 28 days. The results showed that supplementing with ZnO and saZnO for 14 and 28 days significantly improved body weight (BW) and average daily gain (ADG) (p < 0.01) and markedly reduced the feed intake-to-gain ratio (F/G) (p < 0.05) and diarrhea rate. In addition, dietary ZnO and saZnO significantly increased the activities of the total antioxidant capacity (T-AOC) and alkaline phosphatase (ALP) (p < 0.01). Supplementing with saZnO also promoted the levels of superoxide dismutase (SOD), IgM and copper- and zinc-containing superoxide dismutase (Cu/Zn-SOD) in serum (p < 0.05), whereas a ZnO addition decreased the concentration of malondialdehyde (MDA) (p < 0.05), indicating the beneficial effect of Zn on antioxidant and immune functions. Piglets fed the ZnO diet showed higher serum Zn accumulations than those fed the CON and saZnO diets at d 28 (p < 0.01), and supplementing with ZnO and saZnO markedly contributed to Zn excretion in feces, especially in the ZnO diet (p < 0.01). Additionally, piglets fed the saZnO diet had greater valeric acid concentrations (p < 0.05) in their feces, while other short chain fatty acids (SCFAs) were not affected by different treatments (p > 0.05). Microbial alpha diversity was reduced in the saZnO group compared with the CON group (p < 0.05), while an obvious separation of microbial composition, the marker of beta diversity, was shown among the three groups (p < 0.05). At the genus level, six genera, including Clostridium_sensu_stricto_1, Terrisporobacter, f_Muribaculaceae, Subdoligranulum and Intestinibacter, were pronouncedly increased in the ZnO and saZnO groups (p < 0.05); another nine species were dramatically downregulated, such as f_Lachnospiraceae, f_Prevotellaceae, f_Butyricicoccaceae and f_Ruminococcaceae (p < 0.05). Finally, a functional analysis indicated that altered microbes significantly changed the “Metabolism” pathway (p < 0.05). These findings suggested that saZnO could act as a feasible substitute for ZnO to reduce Zn emission and enhance growth performance, antioxidant and immune functions, and to adjust the structure of gut microbiota in piglets.

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Section: Discussionsupporting

confidence: 92%

The Effect of Sodium Alginate-Coated Nano-Zinc Oxide on the Growth Performance, Serum Indexes and Fecal Microbial Structure of Weaned Piglets

Xiao,

Guo,

Liu

et al. 2023

Animals

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Preparation, Structural Analysis, and Growth‐Promoting Effects of Amomum longiligulare Polysaccharide 1‐Mg (II) Complex

Chen,

Wu,

Zhang

et al. 2024

Macromolecular Bioscience

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In this study, Amomum longiligulare polysaccharide 1 (ALP1) is used to chelate with magnesium (Mg) to synthesize the ALP1‐Mg (II) complex (ALP1‐Mg). Based on Box‐Behnken response surface design, the optimum technological conditions are 22 mg mL−1 trisodium citrate, 2.10 mol L−1 MgCl2, reaction at 70 °C for 2.9 h, resulting in a maximum Mg content of 2.13%. Next, the physicochemical properties and structural characteristics of ALP1 and ALP1‐Mg are characterized, and the results show that the morphology, conformation, crystallinity, and thermal stability of ALP1‐Mg are changed. In addition, dietary supplementation of 500 mg kg−1 ALP1‐Mg significantly reduces the feed conversion ratio during the grower (15–35 d). Meanwhile, the villus height/crypt depth of the duodenum and ileum are significantly increased, and the relative abundance of Lactobacillus is significantly elevated. Taken together, the results suggest that ALP1‐Mg is a potential growth‐promoting feed additive.

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Health benefits of the blooming seaweed Ulva prolifera: A review

Zheng,

Huang,

Zhou

et al. 2025

Aquaculture

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Regulatory Effects Mediated by Enteromorpha prolifera Polysaccharide and Its Zn(II) Complex on Hypoglycemic Activity in High-Sugar High-Fat Diet-Fed Mice

Cited by 5 publications

References 57 publications

The Effect of Sodium Alginate-Coated Nano-Zinc Oxide on the Growth Performance, Serum Indexes and Fecal Microbial Structure of Weaned Piglets

The Effect of Sodium Alginate-Coated Nano-Zinc Oxide on the Growth Performance, Serum Indexes and Fecal Microbial Structure of Weaned Piglets

Preparation, Structural Analysis, and Growth‐Promoting Effects of Amomum longiligulare Polysaccharide 1‐Mg (II) Complex

Health benefits of the blooming seaweed Ulva prolifera: A review

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