Regulatory Effects of 5-Hydroxytryptamine Receptors on Voiding Function

Abstract

Grants-in-Aid for Scientific Research (C) (KAKENHI 23590707, 24590722, and 26460694) from the Japan Society for the Promotion of Science.

Evidence for an urethro‐vesical crosstalk mediated by serotonin

“…However, the bladder expresses 5-HT receptors. 25 Nevertheless, intravesical instillation of 5-HT into the bladder, under isovolumetric conditions, had no effect on its reflex activity. The lack of agonist and the absence of a response to 5-HT instillation despite the numerous 5-HT receptors is difficult to understand and the present study could not give further insights on the matter.…”

“…Bladder levels of 5‐HT were very low which was in agreement with the lack of 5‐HT‐IR observed. However, the bladder expresses 5‐HT receptors . Nevertheless, intravesical instillation of 5‐HT into the bladder, under isovolumetric conditions, had no effect on its reflex activity.…”

Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats

“…Administration of 5‐HTP, a 5‐HT precursor, induced a significant increase in urinary 5‐HIAA and shortened the interval between bladder contractions, suggesting that peripheral excitatory action of 5‐HT on vesical smooth muscles induced urinary frequency . In addition, administration of PCPA decreased the 5‐HT level but had no effect on the micturition reflex, suggesting that PCPA blocked both the peripheral and central serotonergic nervous systems to a similar extent.…”

“…On urinary bladder smooth muscle, 5‐HT1A, 5‐HT2, 5‐HT3, and 5‐HT7 subtypes may function as postjunctional receptors . Postjunctional 5‐HT2 receptors induce detrusor contraction of the bladder body.…”

“…On urinary bladder smooth muscle, 5-HT1A, 5-HT2, 5-HT3, and 5-HT7 subtypes may function as postjunctional receptors. 21 Postjunctional 5-HT2 receptors induce detrusor contraction of the bladder body. 5-HT1A may have a similar effect as 5-HT2, whereas 5-HT3 may suppress detrusor contraction evoked by direct muscle stimulation.…”