Regulatory effects of COL1A1 on apoptosis induced by radiation in cervical cancer cells

Liu, Shurong; Liao, Gaoliang; Li, Guowen

doi:10.1186/s12935-017-0443-5

Cited by 53 publications

(46 citation statements)

References 35 publications

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“…The results of the present study are in agreement with those of a previous study that demonstrated that there was elevated COL1A1 expression in cancer ( 54 ). A previous in vitro study also suggested that COL1A1 activity may promote cancer cell proliferation and/or invasion ( 7 ).…”

Section: Discussionsupporting

confidence: 93%

Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma

Sun

Wang

et al. 2018

Int J Oncol

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Malignant astrocytoma (MA) is the most common and severe type of brain tumor. A greater understanding of the underlying mechanisms responsible for the development of MA would be beneficial for the development of targeted molecular therapies. In the present study, the upregulated differentially expressed genes (DEGs) in MA were obtained from the Gene Expression Omnibus database using R/Bioconductor software. DEGs in different World Health Organization classifications were compared using the Venny tool and 15 genes, including collagen type I α1 chain (COL1A1) and laminin subunit γ1 (LAMC1), were revealed to be involved in the malignant progression of MA. In addition, the upregulated DEGs in MA were evaluated using functional annotations of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes with the Database for Annotation, Visualization, and Integrated Discovery tool. The results indicated that invasion-associated enrichment was observed in 'extracellular matrix' (ECM), 'cell adhesion' and 'phosphoinositide 3-kinase-protein kinase B signaling pathway'. Subsequently, the analysis of the protein-protein interactions was performed using STRING and Cytoscape software, which revealed that the ECM component was the invasion-associated module and its corresponding genes included COL1A1, LAMC1 and fibronectin 1. Finally, survival Kaplan-Meier estimate was conducted using cBioportal online, which demonstrated that COL1A1 expression affected the survival of and recurrence in patients with MA. Moreover, the results of in vitro Transwell assay and western blot analysis revealed that the depleted levels of COL1A1 also decreased the expression of several proteins associated with cell invasion, including phosphorylated-signal transducer and activator of transcription 3, matrix metalloproteinase (MMP)-2, MMP-9 and nuclear factor-κB. On the whole, the present study identified the invasion-related target genes and the associated potential pathways in MA. The results indicated that COL1A1 may be a candidate biomarker for the prognosis and treatment of MA.

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Section: Discussionsupporting

confidence: 93%

Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma

Sun

Wang

et al. 2018

Int J Oncol

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“…COL1A1 and COL4A1 are family members of human collagen genes. COL1A1 encodes the major component of fibrillar collagen found in most connective tissues, and involved in gap junction, cell proliferation and tumor invasion [ 42 , 43 ]. COL4A1 is an important flexible protein in the structure of the basement membranes interacted with nearby cells, playing a role in cell migration and growth [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Regulatory network of circRNA–miRNA–mRNA contributes to the histological classification and disease progression in gastric cancer

et al. 2018

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BackgroundLittle has been known about the role of non-coding RNA regulatory network in the patterns of growth and invasiveness of gastric cancer (GC) development.MethodsMicroRNAs (miRNAs) microarray was used to screen differential miRNA expression profiles in Ming’s classification. The significant differential expressions of representative miRNAs and their interacting circular RNA (circRNA) were confirmed in GC cell line and 63 pairs of GC samples. Then, a circRNA/miRNA network was constructed by bioinformatics approaches to identify molecular pathways. Finally, we explored the clinical value of the common targets in the pathway by using receiver operating characteristic curve and survival analysis.ResultsSignificantly differential expressed miRNAs were found in two pathological types of GC. Both of miR-124 and miR-29b were consistently down-regulated in GC. CircHIPK3 could play a negative regulatory role on miR-124/miR-29b expression and associated with T stage and Ming’s classification in GC. The bioinformatics analyses showed that targets expression of circHIPK3-miR-124/miR-29b axes in cancer-related pathways was able to predict the status of GC and associated with individual survival time.ConclusionsThe targets of circHIPK3-miR-124/miR-29b axes involved in the progression of GC. CircHIPK3 could take part in the proliferation process of GC cell and may be potential biomarker in histological classification of GC.Electronic supplementary materialThe online version of this article (10.1186/s12967-018-1582-8) contains supplementary material, which is available to authorized users.

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“…Collagen can stimulate additional signaling pathways in cancer cells to exert various functions. The increased expression of COL1A1 affected the caspase-3/PI3K/AKT pathways to inhibit cell apoptosis in cervical cancer tissues [73]. After the withdrawal of rapamycin treatment, mutated COL1A1 reinforced PI3K-AKT-mammalian target of rapamycin (mTOR) signals in cancer stem cells to sustain the metastatic burden of ERα-positive breast cancer cells; however, lung metastases were independent of mTOR signaling [74].…”

Section: The Influence Of Collagen On Cancer Cell Behaviormentioning

confidence: 99%

The role of collagen in cancer: from bench to bedside

et al. 2019

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Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collagen can influence tumor cell behavior through integrins, discoidin domain receptors, tyrosine kinase receptors, and some signaling pathways. Exosomes and microRNAs are closely associated with collagen in cancer. Hypoxia, which is common in collagen-rich conditions, intensifies cancer progression, and other substances in the extracellular matrix, such as fibronectin, hyaluronic acid, laminin, and matrix metalloproteinases, interact with collagen to influence cancer cell activity. Macrophages, lymphocytes, and fibroblasts play a role with collagen in cancer immunity and progression. Microscopic changes in collagen content within cancer cells and matrix cells and in other molecules ultimately contribute to the mutual feedback loop that influences prognosis, recurrence, and resistance in cancer. Nanoparticles, nanoplatforms, and nanoenzymes exhibit the expected gratifying properties. The pathophysiological functions of collagen in diverse cancers illustrate the dual roles of collagen and provide promising therapeutic options that can be readily translated from bench to bedside. The emerging understanding of the structural properties and functions of collagen in cancer will guide the development of new strategies for anticancer therapy.

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Regulatory effects of COL1A1 on apoptosis induced by radiation in cervical cancer cells

Cited by 53 publications

References 35 publications

Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma

Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma

Regulatory network of circRNA–miRNA–mRNA contributes to the histological classification and disease progression in gastric cancer

The role of collagen in cancer: from bench to bedside

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