Regulatory effects of oral microbe on intestinal microbiota and the illness

Abstract

Over the past decade, the association between oral health, intestinal microbiota, and systemic diseases has been further validated. Some oral microbial species have been isolated from pathological intestine mucosa or feces and identified as biomarkers for intestinal diseases. A small proportion of oral microbiome passes through or colonizes the lower gastrointestinal tract, even in healthy individuals. Opportunistic pathogens from the oral cavity may expand and participate in the occurrence and progression of intestinal diseases when the anatomical barrier is disrupted. These disruptors interact with the intestinal microbiota, disturbing indigenous microorganisms, and mucosal barriers through direct colonization, blood circulation, or derived metabolite pathways. While interacting with the host’s immune system, oral-derived pathogens stimulate inflammation responses and guide the transition of the intestinal microenvironment from a healthy state to a pre-disease state. Therefore, the oral-gut microbiome axis sheds light on new clinical therapy options, and gastrointestinal tract ecology balance necessitates simultaneous consideration of both oral and gut microbiomes. This review summarizes possible routes of oral microbes entering the intestine and the effects of certain oral bacteria on intestinal microbiota and the host’s immune responses.

Tuberculosis-induced aplastic crisis and atypical lymphocyte expansion in advanced myelodysplastic syndrome: A case report and review of literature

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Gut microbiota profile in CDKL5 deficiency disorder patients as a potential marker of clinical severity

“…We also noticed a peculiar increase in the relative abundance of bacterial species characteristic of the oral microbiota in CDD, including Granulicatella adiacens, Streptococcus salivarius and Veillonella parvula. Oral-derived microorganisms have been shown to trigger inflammatory responses, promoting their translocation within the intestinal microenvironment 35 , creating a potentially harmful vicious cycle 36 . Intestinal inflammation, as evidenced by recent studies 37 , has been shown to not only promote the occurrence of seizures but also to influence the responsiveness to anti-seizure medication (ASMs) 38 .…”

Gut microbiota profile in CDKL5 deficiency disorder patients as a potential marker of clinical severity

“…We also noticed a peculiar increase in the relative abundance of bacterial species characteristic of the oral microbiota in CDD, including Granulicatella adiacens, Streptococcus salivarius and Veillonella parvula. Oral-derived microorganisms have been shown to trigger in ammatory responses, promoting their translocation within the intestinal microenvironment 35 , creating a potentially harmful vicious cycle 36 . Intestinal in ammation, as evidenced by recent studies 37 , has been shown to not only promote the occurrence of seizures but also to in uence the responsiveness to anti-seizure medication (ASMs) 38 .…”