Regulatory effects of paeoniflorin-6′-O-benzene sulfonate (CP-25) on dendritic cells maturation and activation via PGE2-EP4 signaling in adjuvant-induced arthritic rats

Jia, Xiaoyi; Cao, Yan; Sun, Xiaojing; Fang, Wei; Wu, Yujing; Dai, Xing; Xu, Shu; Wu, Huaxun; Wang, Chun; Yang, Xiaofang; Wei, Wei

doi:10.1007/s10787-019-00575-8

Cited by 14 publications

(8 citation statements)

References 43 publications

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“…CP‐25 is an active monomer obtained by modifying the structure of Pae in our laboratory. Previous studies in adjuvant arthritis, CIA, and SS models have shown that CP‐25 can regulate B cells (Chen et al, 2020), T cells (Wang et al, 2018), dendritic cells (Jia et al, 2019) and endothelial cells (Han, Liu, et al, 2020) function, with potential soft regulation of inflammatory immune responses (SRIIR) activity. SRIIR refers to that drug selectively regulates cell functions, gene and protein expression or activity to normal physiological levels when the inflammatory immune response is abnormally activated, rather than completely inhibiting it.…”

Section: Discussionmentioning

confidence: 99%

Paeoniflorin‐6′‐o‐benzene sulfonate (CP‐25) improves vasculitis through inhibiting IL‐17A/JAK/STAT3 signaling pathway in endothelial cells of HFD CIA rats

Cai

et al. 2020

Phytotherapy Research

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Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects not only joints but also multiple organ systems including cardiovascular system. Endothelial dysfunction plays an important role in cardiovascular diseases (CVD). In RA, endothelial dysfunction exists at both the macrovascular and the microvascular levels, which is a precursor to vasculitis. This study aimed to investigate the pathogenesis of vasculitis and the therapeutic effect of CP‐25 on vasculitis in high‐fat diet (HFD) collagen‐induced arthritis (CIA) rats. Experimental groups were divided into normal group, HFD group, CIA group, HFD CIA group, CP‐25 group and MTX group. In vitro, IL‐17A was used to stimulate human umbilical vein endothelial cells (HUVECs), and then CP‐25 was used to intervene. Results showed that CP‐25 reduced global scoring (GS), arthritis index (AI), and swollen joint count (SJC) scores, improved histopathological score, reduced T cells percentage, and decreased IL‐17A and ICAM‐1 levels. Besides, CP‐25 reduced the expression of p‐STAT3 to normal levels in vascular of HFD CIA rats. In vitro, IL‐17A promoted the expression of p‐JAK1, p‐JAK2, p‐JAK3, pSTAT3, and ICAM‐1, and CP‐25 inhibited the expression of p‐JAK1, p‐JAK2, p‐JAK3, p‐STAT3, and ICAM‐1. In conclusion, CP‐25 might inhibit endothelial cell activation through inhibiting IL‐17A/JAK/STAT3 signaling pathway, which improves vasculitis in HFD CIA rats.

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Section: Discussionmentioning

confidence: 99%

Paeoniflorin‐6′‐o‐benzene sulfonate (CP‐25) improves vasculitis through inhibiting IL‐17A/JAK/STAT3 signaling pathway in endothelial cells of HFD CIA rats

Cai

et al. 2020

Phytotherapy Research

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“…Besides, research finds that PGE2 can not only promote the intension of inflammatory pain by also enhancing the sensitization of bradykinin and histamineinduced nociceptive stimuli, but also accelerate the plasma extravasation induced edema during the RA disease. In the meantime, studies have been shown that the effect of IL-1, IL-6 and TNF-α on bone resorption is mainly by a PGE2 dependent way (Jia et al, 2019). Extracts from a famous Chinese herbal called Tripterygium wilfordii Hook.…”

Section: Cyclooxygenase (Cox) and Prostaglandins (Pgs)mentioning

confidence: 99%

Research Progress of Therapeutic Enzymes and Their Derivatives: Based on Herbal Medicinal Products in Rheumatoid Arthritis

Cai

Han

et al. 2021

Front. Pharmacol.

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Rheumatoid arthritis (RA) acts as one of the most common, agnogenic and chronic inflammatory-autoimmune disorder which is characterized by persistent synovitis, cartilage destruction, and joint deformities, leads to a wide range of disabilities, and increased mortality, thus imposing enormous burdens. Several drugs with anti-inflammatory and immunomodulatory properties such as celecoxib, diclofenac and methotrexate are being selected as conventional drugs in the allopathic system of medicine for the treatment of RA in clinic. However, there are some serious side effects more or less when using these drugs because of their short poor bioavailability and biological half-life for a long time. These shortcomings greatly promote the exploration and application of new low- or no-toxicity drugs for treating the RA. Meanwhile, a growing number of studies demonstrate that several herbs present certain anti-inflammatory and anti-arthritic activities through different enzymes and their derivatives, which indicate that they are promising therapeutic strategies when targeting these mediators based on herbal medicinal products in RA research. This review article summarizes the roles of the main enzymes and their derivatives during the pathogenesis of RA, and clearly clarifies the explicit and potential targeted actions of herbal medicinal products that have anti-RA activity. Our review provides timely and critical reference for the scientific rationale use of herbal medicinal products, with the increasing basic research and clinical application of herbal medicinal products by patients with RA.

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“…Paeoniflorin can di-minish pain, joint swelling, synovial hypertrophy, bone erosion, and cartilage degradation in experimental arthritis [63,64]. It has been reported that paeoniflorin alleviated AA in rats by inhibiting DC maturation and activation [65]. Paeoniflorin also regulates immune function by affecting splenic T cells in rats with AA [66].…”

Section: Paeonia Lactiflora Pallasmentioning

confidence: 99%

Natural Plant Extracts and Compounds for Rheumatoid Arthritis Therapy

et al. 2021

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Natural plant extracts and compounds (NPECs), which originate from herbs or plants, have been used in the clinical treatment of rheumatoid arthritis (RA) for many years. Over the years, many scientists have carried out a series of studies on the treatment of RA by NPEC. They found a high quantity of active NPECs with broad application prospects. In view of various complex functions of these NPECs, exploring their potential as medicines for RA treatment will be beneficial for RA patients. Thus, to help advance the development of high-quality NPECs for RA, we herein aimed to review the research progress of NPECs in the treatment of RA in recent years. Our findings showed that, from the pharmacological perspective, natural plant extracts or mixed herbal compounds effectively regulate the immune system to alleviate RA by inhibiting pro-inflammatory cytokines. Further, individualized medication can be applied according to each patient’s physical condition. However, the pathogenesis of RA and its immune mechanism has not been fully understood and requires further studies.

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Regulatory effects of paeoniflorin-6′-O-benzene sulfonate (CP-25) on dendritic cells maturation and activation via PGE2-EP4 signaling in adjuvant-induced arthritic rats

Cited by 14 publications

References 43 publications

Paeoniflorin‐6′‐o‐benzene sulfonate (CP‐25) improves vasculitis through inhibiting IL‐17A/JAK/STAT3 signaling pathway in endothelial cells of HFD CIA rats

Paeoniflorin‐6′‐o‐benzene sulfonate (CP‐25) improves vasculitis through inhibiting IL‐17A/JAK/STAT3 signaling pathway in endothelial cells of HFD CIA rats

Research Progress of Therapeutic Enzymes and Their Derivatives: Based on Herbal Medicinal Products in Rheumatoid Arthritis

Natural Plant Extracts and Compounds for Rheumatoid Arthritis Therapy

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