2012
DOI: 10.1002/ibd.21818
|View full text |Cite
|
Sign up to set email alerts
|

Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro

Abstract: These data show that regulatory macrophages may be involved in mucosal healing and provide a rationale for the superiority of infliximab/azathioprine combination treatment observed in the clinic.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

13
141
1

Year Published

2014
2014
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 162 publications
(155 citation statements)
references
References 22 publications
13
141
1
Order By: Relevance
“…Regulatory macrophages, expressing the markers CD206 and CD68, were also observed in infliximab-treated IBD patients with signs of mucosal healing [31]. These regulatory macrophages (M2 macrophages) suppressed T cell proliferation and promoted wound healing [31]. We observed that, in spite of increased TNF secretion, macrophages from CD-IFX patients also showed increased IL-10 production in response to bacteria, thus confirming the results obtained by Vos and collaborators [12].…”
Section: Cd16supporting
confidence: 89%
See 2 more Smart Citations
“…Regulatory macrophages, expressing the markers CD206 and CD68, were also observed in infliximab-treated IBD patients with signs of mucosal healing [31]. These regulatory macrophages (M2 macrophages) suppressed T cell proliferation and promoted wound healing [31]. We observed that, in spite of increased TNF secretion, macrophages from CD-IFX patients also showed increased IL-10 production in response to bacteria, thus confirming the results obtained by Vos and collaborators [12].…”
Section: Cd16supporting
confidence: 89%
“…Azathioprine administered concomitantly with infliximab further increased IL-10 secretion in response to MAP, which is in agreement with azathioprine's immunosuppressive role. The results we obtained concerning IL-10 are in favour of an infliximabdependent induction of regulatory macrophages, as demonstrated by Vos and collaborators [12,31]. As CD-IFX macrophages produced both high TNF and IL-10 in response to bacteria, it is possible that they belong to M2b macrophages, a subgroup of the M2 phenotype [32,33] induced by immune complexes and known to secrete both TNF and IL-10.…”
Section: Cd16supporting
confidence: 69%
See 1 more Smart Citation
“…Macrophages, dependent upon their phenotype, are important effector cells of both the initiation/maintenance of inflammatory response and the resolution/regeneration processes. Regulatory M2-like macrophages have been associated with mucosal healing outcomes [21,22] in preclinical models of IBD. Similarly, the restoration of functional tissues via ECM bioscaffold mediated events in a variety of regenerative medicine applications has been shown to be either associated with, or dependent upon a timely shift in macrophage phenotype toward M2 predominance [23,24,25].…”
Section: Discussionmentioning
confidence: 99%
“…They also found that M2 macrophages make up only about one-third to one-fifth of colonic macrophages in CD, as determined by staining for c-Maf, an important transcription factor for mediating IL-10 gene expression in macrophages, in CD163-or CD68-positive colonic macrophages, respectively. M2 macrophages, as determined by positivity for the M2 marker CD206, have been shown by Hunter et al (37) and Vos et al (99) to contribute to less than one-fifth of colonic macrophages stained with CD68 by immunofluorescence and immunohistochemistry, respectively, in tissue from patients with CD (37,99).…”
Section: Ogino and Colleagues (70) Observed Cd14mentioning
confidence: 93%