Regulatory mechanism of microRNA-155 in chicken embryo fibroblasts in response to reticuloendotheliosis virus infection

Gao, Chang; Dang, Shengyuan; Zhai, Jie; Zheng, Shangen

doi:10.1016/j.vetmic.2020.108610

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…For miR-155, it showed a high expression level during REV infection in CEF cells. It has been demonstrated that miR-155 could inhibit apoptosis by targeting caspase-6 and accelerate cell cycle through inhibiting FOXO3a and JARID2 (jumonji, AT rich interactive domain 2) expression during the REV infection [141,142]. For novel-72, it showed a significantly lower expression in REV-infected cells.…”

Section: Ncrnas and Reticuloendotheliosis (Re)mentioning

confidence: 99%

“…The selected-verified miRNAs and their target genes and their functions during the IBDV, IBD, NDV, AIV, and REV infections were listed below ( Table 5). FOXO3a, JARID2 inhibit apoptosis and accelerate cell cycle during the REV infection [141,142] As avian virus disease has been well studied, the mechanisms that miRNAs participate in avian virus diseases are clear now. There are four functional mechanisms have been reported: (1) Direct interaction with the host gene (Figure 2a) [82]; (2) acts as homologous to virus-encoded miRNAs and shares the same target gene with virus-encoded miRNAs (Figure 2b) [92][93][94][95][96][97]143]; 3interacts with virus genomic gene (Figure 2c) [98,99,[107][108][109]; (4) alters the expression of responsible miRNAs through inducing the demethylation of the miRNA promoter to protect virus themselves to survival from the immune responses induced by related-miRNAs ( Figure 2d) [114,115].…”

Section: Ncrnas and Reticuloendotheliosis (Re)mentioning

confidence: 99%

“…miRNAs can regulate various aspects of immune response process. In avian, some specific miRNAs were identified to be differentially expressed in many different types of chicken diseases from virus, parasite, and bacteria, such as miR-155 [68,110,141,142], miR-221/222 [60,83,119,138], miR-130 [59,90,109], miR-30 [121,152,155], miR-34 [59,63,132,154,163], let-7 [57,81,155], miR-181 [77,134,155], miR-16 [80,115], miR-455 [125,134,155], etc. It indicated their extensive roles in regulating avian immunity.…”

Section: Ncrnas and Salmonella Typhimuriummentioning

confidence: 99%

“…It indicated their extensive roles in regulating avian immunity. Especially, miR-155 has been reported to play important roles in response to different kinds of avian diseases, such as ALV [68], MD [76], IBD [110], Avian influenza [132], Reticuloendotheliosis [141,142], Campylobacter jejuni [151], and also Salmonella enterica serovar Enteritidis [162].…”

Section: Ncrnas and Salmonella Typhimuriummentioning

confidence: 99%

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Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System

Chen

Abdalla

et al. 2020

Life

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The identified non-coding RNAs (ncRNAs) include circular RNAs, long non-coding RNAs, microRNAs, ribosomal RNAs, small interfering RNAs, small nuclear RNAs, piwi-interacting RNAs, and transfer RNAs, etc. Among them, long non-coding RNAs, circular RNAs, and microRNAs are regulatory RNAs that have different functional mechanisms and were extensively participated in various biological processes. Numerous research studies have found that circular RNAs, long non-coding RNAs, and microRNAs played their important roles in avian immune system during the infection of parasites, virus, or bacterium. Here, we specifically review and expand this knowledge with current advances of circular RNAs, long non-coding RNAs, and microRNAs in the regulation of different avian diseases and discuss their functional mechanisms in response to avian diseases.

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Section: Ncrnas and Reticuloendotheliosis (Re)mentioning

confidence: 99%

Section: Ncrnas and Reticuloendotheliosis (Re)mentioning

confidence: 99%

Section: Ncrnas and Salmonella Typhimuriummentioning

confidence: 99%

Section: Ncrnas and Salmonella Typhimuriummentioning

confidence: 99%

See 2 more Smart Citations

Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System

Chen

Abdalla

et al. 2020

Life

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“…In poultry, reticuloendotheliosis virus (REV) infection leads to immunosuppression, acute reticuloma, short stature syndrome, and lymphoid and other chronic tumorous proliferative diseases ( 1 ). REV prevalence is primarily combined with other immunosuppressive viruses such as Marek's disease virus (MDV) and subgroup J avian leukosis virus, which complicate disease diagnosis and prevention ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Tandem Mass Tag-Based Quantitative Proteomic Analysis of Chicken Bursa of Fabricius Infected With Reticuloendotheliosis Virus

Yang

Zhang

et al. 2021

Front. Vet. Sci.

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Reticuloendotheliosis virus (REV) is a type C avian retrovirus that causes immunosuppression, dwarf syndrome, and lymphoma in infected hosts. In this study, we used tandem mass tag (TMT) labeling and liquid chromatography–tandem mass spectrometry (LC-MS/MS) to characterize protein alterations in chicken bursa of Fabricius, before and after REV infection at 7, 14, 21, and 28 days. Our data showed that 1,127, 999, 910, and 1,138 differentially expressed proteins were significantly altered at 7, 14, 21, and 28 days after REV infection, respectively. Morphological analysis showed that REV infection reduced in cortical lymphocytes, bursal follicle atrophy, and nuclear damage. Bioinformatics analysis indicated these proteins were mainly involved with immune responses, energy metabolism, cellular processes, biological regulation, metabolic processes, response to stimuli, and multicellular organismal process. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway cluster analysis showed that post-infection, proteins were enriched in the cell cycle, Wnt signaling, antigen processing and presentation, cytokine receptor interaction, adenosine 3′,5′-cyclic monophosphate signaling pathway, and NF-κB signaling. In addition, we observed that peroxiredoxin 4 (PRDX4), peroxiredoxin 6 (PRDX6), glutathione peroxidase 3 (GPX3), catalase (CAT), and peroxidasin (PXDN) were involved in oxidative stress. Some heat shock protein (HSP) family members such as HSPH1, DNAJA4, HSPA8, and HSPA4L also changed significantly after REV infection. These findings help clarify interactions between REV and the host and provides mechanistic insights on REV-induced host immunosuppression.

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Host miRNA and mRNA profiles during in DEF and duck after DHAV-1 infection

Wang,

Liu,

Cheng

et al. 2024

Sci Rep

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DHAV-1 is a highly infectious pathogen that can cause acute hepatitis in ducklings. MicroRNA (miRNA) plays an essential regulatory role in virus response. We characterized and compared miRNA and mRNA expression profiles in duck embryonic fibroblasts (DEF) and the liver of ducklings infected with DHAV-1. DHAV-1 infected DEF was divided into infection group (D group) and blank group (M group), and DHAV-1 infected duckling group was divided into infection group (H group) and blank group (N group). D vs. M have 130 differentially expressed (DE) miRNA (DEM) and 2204 differentially expressed (DE) mRNA (DEG), H vs. N have 72 DEM and 1976 DEG. By the intersection of D vs. M and H vs. N comparisons, 15 upregulated DEM, 5 downregulated DEM, 340 upregulated DEG and 50 downregulated DEG were found with both in vivo and in vitro DHAV-1 infection. In particular, we identified the same DE miRNA target genes and functional annotations of DE mRNA. We enriched with multiple gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, which may have important roles in viral virulence, host immunity, and metabolism. We selected miR-155, which is co-upregulated, and found that miR-155 targets SOCS1 to inhibit DHVA-1 replication. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-72992-x.

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Regulatory mechanism of microRNA-155 in chicken embryo fibroblasts in response to reticuloendotheliosis virus infection

Cited by 6 publications

References 29 publications

Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System

Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System

Tandem Mass Tag-Based Quantitative Proteomic Analysis of Chicken Bursa of Fabricius Infected With Reticuloendotheliosis Virus

Host miRNA and mRNA profiles during in DEF and duck after DHAV-1 infection

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