Regulatory Mechanisms and Reversal of CD8+T Cell Exhaustion: A Literature Review

Zhu, Wanwan; Li, Yiming; Meng, Han; Jiang, Jian‐Li

doi:10.3390/biology12040541

Cited by 6 publications

(3 citation statements)

References 148 publications

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“…In the Ce6-mediated PDT group, the Cd69 activation signature gene; the Lck , Plac8 , and Il7r memory-like T cell markers; and the Gzmb and Prf1 cytotoxicity signature genes were expressed at higher levels compared with the control group in all T cell subsets ( Figure 2 I). In contrast, the Lag3 , Havcr2 , and Vsir genes, which are associated with immunoglobulin suppression of T cell activation [ 60 , 61 ] and the distinct regulatory T cell defining genes, Foxp3 , Il2ra , and Tnfrsf18, exhibited decreased expression in the Ce6-mediated PDT group compared with the control group for all T cell subsets. Overall, these findings indicate that more CD8 + activated T cells and CD8 + cytotoxic T cells induced by Ce6-mediated PDT treatment are the predominant populations that correlate with the antitumor immune response.…”

Section: Resultsmentioning

confidence: 99%

“…suppression of T cell activation [60,61] and the distinct regulatory T cell defining genes, Foxp3, Il2ra, and Tnfrsf18, exhibited decreased expression in the Ce6-mediated PDT group compared with the control group for all T cell subsets. Overall, these findings indicate that more CD8 + activated T cells and CD8 + cytotoxic T cells induced by Ce6-mediated PDT treatment are the predominant populations that correlate with the antitumor immune response.…”

Section: Single-cell Rna-seq Analysis Of T Cells In Tumor Tissues By ...mentioning

confidence: 94%

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Single-Cell RNA Sequencing Reveals Immuno-Oncology Characteristics of Tumor-Infiltrating T Lymphocytes in Photodynamic Therapy-Treated Colorectal Cancer Mouse Model

Lee,

Choi,

Han

et al. 2023

IJMS

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Photodynamic therapy (PDT) has shown promise in reducing metastatic colorectal cancer (CRC); however, the underlying mechanisms remain unclear. Modulating tumor-infiltrating immune cells by PDT may be achieved, which requires the characterization of immune cell populations in the tumor microenvironment by single-cell RNA sequencing (scRNA-seq). Here, we determined the effect of Chlorin e6 (Ce6)-mediated PDT on tumor-infiltrating T cells using scRNA-seq analysis. We used a humanized programmed death-1/programmed death ligand 1 (PD-1/PD-L1) MC38 cell allograft mouse model, considering its potential as an immunogenic cancer model and in combination with PD-1/PD-L1 immune checkpoint blockade. PDT treatment significantly reduced tumor growth in mice containing hPD-1/PD-L1 MC38 tumors. scRNA-seq analysis revealed that the PDT group had increased levels of CD8+ activated T cells and CD8+ cytotoxic T cells, but decreased levels of exhausted CD8+ T cells. PDT treatment also enhanced the infiltration of CD8+ T cells into tumors and increased the production of key effector molecules, including granzyme B and perforin 1. These findings provide insight into immune-therapeutic modulation for CRC patients and highlight the potential of PDT in overcoming immune evasion and enhancing antitumor immunity.

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Section: Resultsmentioning

confidence: 99%

Section: Single-cell Rna-seq Analysis Of T Cells In Tumor Tissues By ...mentioning

confidence: 94%

Single-Cell RNA Sequencing Reveals Immuno-Oncology Characteristics of Tumor-Infiltrating T Lymphocytes in Photodynamic Therapy-Treated Colorectal Cancer Mouse Model

Lee,

Choi,

Han

et al. 2023

IJMS

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“…The intricate mechanisms of T cell exhaustion in cancer immunotherapy, including emerging roles of epigenetic reprogramming, have been discussed in recent seminal reviews [ 17 – 19 ]. Epigenetic therapy, also known as epitherapy, utilizes epigenetic-modifying compounds (EMCs) (Fig.…”

Section: Introductionmentioning

confidence: 99%

Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

Xiong,

Zhang,

Sun

2023

Military Med Res

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Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of CD8+ tumor-infiltrating lymphocytes (TILs), which is termed T cell exhaustion. This process is driven by diverse extrinsic factors across heterogeneous tumor immune microenvironment (TIME). Simultaneously, tumorigenesis entails robust reshaping of the epigenetic landscape, potentially instigating T cell exhaustion. In this review, we summarize the epigenetic mechanisms governing tumor microenvironmental cues leading to T cell exhaustion, and discuss therapeutic potential of targeting epigenetic regulators for immunotherapies. Finally, we outline conceptual and technical advances in developing potential treatment paradigms involving immunostimulatory agents and epigenetic therapies.

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LAIR1-mediated resistance of hepatocellular carcinoma cells to T cells through a GSK-3β/β-catenin/MYC/PD-L1 pathway

Pan,

Ke,

Qiu

et al. 2024

Cellular Signalling

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Regulatory Mechanisms and Reversal of CD8+T Cell Exhaustion: A Literature Review

Cited by 6 publications

References 148 publications

Single-Cell RNA Sequencing Reveals Immuno-Oncology Characteristics of Tumor-Infiltrating T Lymphocytes in Photodynamic Therapy-Treated Colorectal Cancer Mouse Model

Single-Cell RNA Sequencing Reveals Immuno-Oncology Characteristics of Tumor-Infiltrating T Lymphocytes in Photodynamic Therapy-Treated Colorectal Cancer Mouse Model

Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

LAIR1-mediated resistance of hepatocellular carcinoma cells to T cells through a GSK-3β/β-catenin/MYC/PD-L1 pathway

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