Regulatory mechanisms of dopamine metabolism in a marine Meyerozyma guilliermondii GXDK6 under NaCl stress as revealed by integrative multi-omics analysis

Sun, Huijie; Bai, Huashan; Hu, Yonghong; He, Sheng; Wei, Ruihang; Meng, Duotao; Jiang, Qiong; Pan, Hongping; Shen, Peihong; Ou, Qian; Jiang, Chengjian

doi:10.1016/j.synbio.2024.01.002

Cited by 2 publications

(1 citation statement)

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“…Specifically, meta-transcriptomics can provide insights into the microbial genetic pathways, by quantifying the abundance of transcripts in a sample reflecting bacterial gene expression activity ( Aitmanaitė et al., 2023 ); Meta-proteomics is complementary to metagenomics and meta-transcriptomic since it reflects the activity of cellular translational and post-translational processes, by measuring the levels of all the proteins synthesized by the microbiota and the host, and, hence, providing insights into the functional role of microorganisms in host health ( Hardouin et al., 2021 ); Metabolomics allow researchers to acquire a better understanding of metabolic and biochemical processes involving the microbiota and the host, by determining the levels of all small molecules in the microenvironment ( Bartsch et al., 2023 ). An interesting application of multi-omics is described in a study on the dopamine metabolism in the marine yeast Meyerozyma guilliermondii GXDK6, by using WGS for identifying the key genes for dopamine biosynthesis, and transcriptomics as well as proteomics for showing the level of activation of the related metabolic pathway ( Sun et al., 2024 ).…”

Section: Towards a Multi-omics Approachmentioning

confidence: 99%

Current progresses and challenges for microbiome research in human health: a perspective

Filardo,

Di Pietro,

Sessa

2024

Front. Cell. Infect. Microbiol.

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It is becoming increasingly clear that the human microbiota, also known as “the hidden organ”, possesses a pivotal role in numerous processes involved in maintaining the physiological functions of the host, such as nutrient extraction, biosynthesis of bioactive molecules, interplay with the immune, endocrine, and nervous systems, as well as resistance to the colonization of potential invading pathogens. In the last decade, the development of metagenomic approaches based on the sequencing of the bacterial 16s rRNA gene via Next Generation Sequencing, followed by whole genome sequencing via third generation sequencing technologies, has been one of the great advances in molecular biology, allowing a better profiling of the human microbiota composition and, hence, a deeper understanding of the importance of microbiota in the etiopathogenesis of different pathologies. In this scenario, it is of the utmost importance to comprehensively characterize the human microbiota in relation to disease pathogenesis, in order to develop novel potential treatment or preventive strategies by manipulating the microbiota. Therefore, this perspective will focus on the progress, challenges, and promises of the current and future technological approaches for microbiome profiling and analysis.

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